Top
30
Doctor insights on: Trial Proleukin Aldesleukin

Share
1

1
Results of trial of proleukin (aldesleukin) in recent onset type 1 diabetes?

Results of trial of proleukin (aldesleukin) in recent onset type 1 diabetes?

Ongoing Study: According to clinicaltrials. Gov, the phase I trial is still on-going; there are no results yet. ...Read more

Dr. Amrita Dosanjh
13 Doctors shared insights

Aldesleukin (Definition)

Aldesleukin is a cancer-related immune system affecting agent which is a ...Read more


2

2
Can phase I trial of proleukin (aldesleukin) and Rapamune lead to type 1 diabetes?

Can phase I trial of proleukin (aldesleukin) and Rapamune lead to type 1 diabetes?

NIH study: The combination of these drugs is being studied in adult patients already diagnosed with type 1 diabetes. The thought is that the combination might help slow down the progress of diabetes. The study isn't complete yet. If there is another phase 1 trial using these drugs in a different study, the investigator should be approached with your question. ...Read more

3

3
Phase I trial of proleukin (aldesleukin) and Rapamune in recent onset type 1 diabetes, what to do?

Phase I trial of proleukin (aldesleukin) and Rapamune in recent onset type 1 diabetes, what to do?

Phase I trials: This is a question best asked of your endocrine specialist. I suppose you are contemplating entering the trial? Do your research and make sure that your questions are answered, be sure that you are willing to make the necessary time commitment. Discuss with family and trusted peers/friends before deciding to join a study.
http://clinicaltrials. Gov/show/NCT00525889 ...Read more

4

4
Any good results from the phase I trial of proleukin (aldesleukin) and Rapamune in recent onset type 1 diabetes?

Any good results from the phase I trial of proleukin (aldesleukin) and Rapamune in recent onset type 1 diabetes?

Probably not: It appears that a phase 1 trial of these medications was attempted in 2007, but results were never published. This probably means that the trial was abandoned. Years ago, another immunosuppressive med was used (cyclosporin) to treat early Type 1 diabetes and was successful in preserving pancreatic function. However further studies were abandoned because of excessive toxicity of this class of med ...Read more

5

5
What makes Trovax different from other kidney cancer meds (like nexavar, proleukin, torisel, (temsirolimus) sutent)?

What makes Trovax different from other kidney cancer meds (like nexavar, proleukin, torisel, (temsirolimus) sutent)?

Other drugs worked: Nexavar, torisel, and sutent all received FDA approval because they improved progression free survival.

The initial Trovax trial was terminated early because there was little or no prospect of demonstrating a statistically significant survival benefit compared to placebo.

http://clincancerres. Aacrjournals. Org/content/16/22/5539.long ...Read more

6

6
Is Interleukin IL-6 typically elevated with advanced stage lymphoma???

Is Interleukin IL-6 typically elevated with advanced stage lymphoma???

Lymphoma: If you have advanced stage lymphoma, the IL-6 level will not make or break the diagnosis. IL-6 is an inflammatory cytokine and anything from infection to arthritis can increase levels. ...Read more

7

7
What is interleukin 12?

What is interleukin 12?

Signaling molecule: Interleukin-12 (il-12) is known as a cytokine, which are small cell-signaling protein molecules that are secreted by numerous cells and are used extensively in intercellular communication. Il-12 is secreted by certain types of immune cells (such as dendritic cells) to regulate other members of the immune cells (for example, natural killer (nk) cells). ...Read more

8

8
Why is interleukin important?

Why is interleukin important?

Interleukins: One of a large group of proteins produced mainly by t cells and in some cases by mononuclear phagocytes or other cells. Interleukins participate in communication among leukocytes and are important in the inflammatory response. Most interleukins direct other cells to divide and differentiate. Each acts on a particular group of cells that have receptors specific to that interleukin. ...Read more

9

9
What are EPO and interleukin-11?

What are EPO and interleukin-11?

Important proteins: Epo (erythropoietin) is a key hormone (made by kidneys in adults, liver in babies) in stimulating/signalling the production of red blood cells--it is used to treat anemia in folks wth kidney failure. Interleukin-11 is a cellular protein encoded by the gene il-11 and is important is regulation of a megakaryocyte--the cell which makes platelets. Very complex processes. Have fun learning. Good luck. ...Read more

10

10
Is interleukin 6 (IL-6) elevated in lymphoma?

Is interleukin 6 (IL-6) elevated in lymphoma?

IL6: IL6 is a blood marker of inflammation. It can be seen elevated in some cases of lymphoma or be elevated in other medical conditions not necessarily lymphoma. ...Read more

11

11
Does interleukin inhibit or turn down the immune response?

Does interleukin inhibit or turn down the immune response?

Interleukins: One of a large group of proteins produced mainly by t cells and in some cases by mononuclear phagocytes or other cells. Interleukins participate in communication among leukocytes and are important in the inflammatory response. Most interleukins direct other cells to divide and differentiate. Each acts on a particular group of cells that have receptors specific to that interleukin. ...Read more

12

12
Is interleukin-1 increased in fever?

Is interleukin-1 increased in fever?

IL 1: Interleukins are cytokines. These are chemical substances released by one cell (often inflammatory), which influence the behavior of other cells. Several interleukins, particularly il 1, are known as pyrogens, in that they may induce fever. Since the interactions among these are quite complex it is possible that the fever was induced by one pyrogen which also caused release of il 1. ...Read more

13

13
What makes interleukin-2 and what makes interferon gamma? Are they both made by t-lymphocytes?

What makes interleukin-2 and what makes interferon gamma? Are they both made by t-lymphocytes?

Yes: Interleukin 2 (aldesleukin) is made by t-cells and is important for the growth of other t-cells. Interferon gamma is made by both t cells and natural killer cells and is part of the innate immune response. ...Read more

15

15
Is it safe to participate in a clinical trial?

Is it safe to participate in a clinical trial?

Not entirely: The purpose of a clinical trial is to see if a new medication or treatment is safe & effective. Many times the answer is that the new treatment does not help. All medicines have side effects, sometimes quite serious, so trying a new medicine can be very risky- they may learn of a serious side effect from your experience! Discuss the potential risks vs. Potential benefits with those conducting it. ...Read more

16

16
Why should I participation in an MS clinical trial?

Why should I participation in an MS clinical trial?

Help others: Advancing our understanding of MS requires the dedication of researchers and also of patients. Clinical trials are the best tools to validate with reproducible evidence that a drug or intervention really has a benefit. Word of mouth or anecdotal evidence often fail to pass these hurdles and amount to pseudoscientific claims, lacking transparency to risk. ...Read more

17

17
What is bid antacid trial to be taken for one month?

What is bid antacid trial to be taken for one month?

Reflux treatment: Means you like have acid reflux and your doctor wants you to take antacids twice daily for one month to see if this helps. This usually refers to proton pump inhibitors (e.g. Omperazole, lansoprazole), but could also refer to h2 receptor blockers (w.G.Peptic, zantac). Both can be obtained otc or by rx. ...Read more

18

18
Would a lymphoma clinical trial be appropriate for me?

It may be: Clinical trials should always be considered when available. You want to know what are the risks and also the benefits as they particularly apply to you and your disease. Your doctor should be able to supply you with this information in a unbiased manner. ...Read more

19

19
How do doctors determine who should be included in a clinical trial?

How do doctors determine who should be included in a clinical trial?

Strict criteria: Every clinical trial has a strict set of selection criteria, determined by the sponsor or principal investigator. These criteria vary based on the condition and treatment being evaluated. ...Read more

20

20
I was wondering is clinical investigation and clinical trial the same thing?

Clinical trial: No one is a trial the other is just looking for something but a trial is always a clinical invest. ...Read more

21

21
Should we stop using deodorant with talc? (after the Johnson and Johnson trial)

Should we stop using deodorant with talc? (after the Johnson and Johnson trial)

Personal choice: Many talc-free deodorant options exist. I personally have no concerns and use many talc containing products. We can't equate a lawyer winning a lawsuit as the equivalent of scientific proof that something is harmful, especially when plenty of evidence exists to suggest that harm is overblown at worst and non-existent at best. Most juries have very poor understanding of science and statistics. ...Read more

22

22
Is a 24 month trial of tasigna (nilotinib) the best way to go about treating a cml diagnosis?

Is a 24 month trial of tasigna (nilotinib) the best way to go about treating a cml diagnosis?

YES: Tasigna (nilotinib) - was initially used as sencond line treatment for CML for patients resistant or intolerant to imatinib. Now it is indicated for first line treatment in CML in chronic phase. Its not a trial but treatment for cml. And yes you are right, we only have 24 month data to date as first line treatment. ...Read more

23

23
My doctor wants me to join a trial for a drug so how do I connect with someone on this trial?

Drug trial: You ask your doctor for more information contact the drug company or the original researcher ask specific questions. ...Read more

24

24
Is having to change my tampon evey 30mins with first trial of birthcontrol too much? Should I stop taking it?

Is having to change my tampon evey 30mins with first trial of birthcontrol too much? Should I stop taking it?

Yes and no: Bleeding heavy enough to change a tampon every hour is too much. Most doctors would recommend you double up on the pill until bleeding is under control. However, your doctor will want to hear about this problem and I would proceed with their recommendations. ...Read more

25

25
I am a possible candidate for the GDNF trial in Bristol UK. What questions should I be asking the Dr involved? .

I am a possible candidate for the GDNF trial in Bristol UK. What questions should I be asking the Dr involved? .

Complication rate: Worthwhile comparing hospital surgical complication rate with other hospitals. Keep in mind that GDNF is a promising treatment for Parkinson's disease, offering the ability to restore normal dopamine production w/in the brain. GDNF does not cross blood-brain barrier well, so ways to get it there (transfused by implanted device in Bristol trial) are researched. 2nd question:can you keep it? ...Read more

26

26
On the delayed recall trial of the ravlt I scored 14/15. On the reverse digit span I scored 8. Does this mean I don't have mci?

On the delayed recall trial of the ravlt I scored 14/15. On the reverse digit span I scored 8. Does this mean I don't have mci?

2 tests not enough: MCI ("mild cognitive impairment") is an evolving term; usually neurologists, neuropsychologists, and psychiatrists use more than just two tests to clarify if a person's cognition were normal; they also take into account history and examination. Certainly the scores you report are reassuring and imply normal, healthy episodic memory and working memory. ...Read more

27

27
I just received my free trial of somnapure pm. When I opened the bottle there was a very strong odor of what appears to be yeast? Is that normal?

I just received my free trial of somnapure pm. When I opened the bottle there was a very strong odor of what appears to be yeast? Is that normal?

Somnapure: This supplement has hops as one of its ingredients. This is the stabilizing agent in beer. Perhaps that is what you are smelling when you open the bottle. However, if you are concerned about the safety, it is always safe to not take this product (which has not been tested to FDA specifications for safety or efficacy). ...Read more

29

29
Just read an artificial wearable kidney is under trial. Want to know about it for my mom. Where can I get all the details. Its effectiveness & price. Thx.

Just read an artificial wearable kidney is under trial. Want to know about it for my mom. Where can I get all the details. Its effectiveness & price. Thx.

Wearable kidney: Just read an artificial wearable kidney is under trial. Want to know about it for my mom. Where can I get all the details. Its effectiveness & price. Thx. ANS: if it is still under trial the only way she can get it is to be in a trial. Contact the folks at : http://hsnewsbeat. Uw.edu/story/faq-seattle-wearable-artificial-kidney-safety-trial
to see if she can get in.
From pictures "wearable" is a stretch ...Read more

Dr. James Dukelow
7 Doctors shared insights

Proleukin (Definition)

Proleukin is a cancer-related immune system affecting agent which is a ...Read more


Find us on Facebook