Doctor insights on:
Treatments For Spindle Cell Sarcoma
Yes it often is: Spindle cell cancers are often called sarcomas. They can arise either in the soft tissues or in the bones. Ask your doctor what is the name of your cancer? If it is a sarcoma, chemotherapy is useful in about half of the cases, often it is used in conjunction with surgery and radiotherapy. ...Read more
By definition, it is malignant (i.e., being locally invasive and at least theoreticlally capable of metastasizing), and arises from / mimics muscle or connective tissue elements that are not marrow or immune / white cells. The sarcomas are a tremendously varied and troublesome family of tumors, though thankfully less common than carcinomas and the leukemia / ...Read more
Some help: High grade spindle cell sarcomas are aggressive and every effort to remove the primary, control the surgical site if larger than 10 cm with RT should be made. If metastatic foci are noted surgical resection can also benefit as seen with lung mets. Primary treatment with drugs like Ifosfamide and platinum may help but primary removal is most important ...Read more
Lots of variety.: The term "spindle cell" sarcoma is a generic descriptive term that doesn't really give enough information. It would be like asking, "I saw a convertible, how fast can it go?" additional testing often reveals exactly what kind of sarcoma, and then once you know that, you can more accurately discuss the prognosis and the treatment. ...Read more
What is the prognosis of Spindle cell melanoma T4 lesion on the scalp?other than the surgery, what other treatments have been successful?
Varies case by case: It is better known as fibromatosis or desmoid tumor since it is benign and is not a sarcoma (cancer). Mainstay of treatment is surgical excision, if it is feasible. Recurrence rate is rather high, so radiation is often given. If tumor cannot be removed safely, options include radiation, low dose chemotherapy and not doing anything and observing. Each case is different, so ask your doctor. ...Read more
Surgery foremost: There are conflicting results on whether radiation and/or any chemotherapy protocol helps at any particular stage. If the tumor has not spread to the lungs, for most patients a 5-year disease-free survival is more likely than not. Unoperated, the disease is lethal. Good luck, and thanks for asking. ...Read more
Yes: Treatment of synovial sarcoma is centered on surgical removal of the tumor with a cuff of normal tissue around it (medical term is wide resection). Radiation is given either before or after surgery in many cases. Use of chemotherapy is controversial as it gives a minimal improvement in survival rates at best. Chances of cure are about 60-70% overall, but every case is different. ...Read more
Still under study: Everyone agrees that surgery is foremost. Whether local radiation and/or adjuvant chemotherapy (and if so what kind) are helpful is still up for grabs, with different studies giving different results for different stages of tumor. Unless the disease has spread to the lungs, the chances of long-term survival are generally better than even. Good luck. ...Read more
Yes possible in: Europe and usa and many other countries. ...Read more
Surgery +/-radiation: In general sarcomas are treated with surgical removal with negative margins which means that the tumor doesn't go up to the edge of the specimen in any area. Depending on the sarcoma type, surgical results, and sarcoma grade, radiation therapy after the surgery may be given. Chemotherapy is reserved for advanced cases. ...Read more
Combo chemo/surgery.: Systemic chemotherapy with doxorubicin, ifosfamide, etoposide, and vincristine is effective and done before limb saving surgery. Peripheral primary lesions (below the elbow and mid-calf) can have a 5-year survival of 80%. Even metatstatic disease has a 25-40% cure rate with high dose therapy and stem cell transplant. ...Read more
Treatment is....: Multimodal. Cytoreductive neoadjuvant therapy (vincristine, adriamycin, (doxorubicin) cytoxan, Ifosfamide and etoposide) is used, then surgery with or without radiation tx, then more chemo with the same agents. There are ongoing trials to evaluate new agents and approaches. ...Read more
Treatment KS: Have you failed the standard therapy like Doxil or paclitaxel? There are new medications on studies for ks such as pomalidomide, selumetinib, vismodegib, Doxil plus Avastin (bevacizumab) etc. Open this www.Clinicaltrials. Gov and enter kaposi's sarcoma. Discuss with your md in regard to clinical trials. ...Read more
How curable is a soft tissue sarcoma of the calf? Expected disease free life expectancy and treatment options?
Surgery +/- RT: Most soft tissue sarcomas of the extremities are treated with surgery to completely remove the cancer ("negative" margins) then possibly also post-surgery radiation therapy or rt. Prognosis, and the need for rt, depends on the tumor type and grade, or how aggressively it is growing under the microscope. ...Read more
What is the treatment after a year of chemo for patient with stage four swings sarcoma? 28 year old african american male with spots on lungs
This is a difficult tumor to treat. The options for treatment of metastatic ewing's sarcoma are chemo and local radiation or surgery. The chemotherapies that have worked best include vincristine, doxorubicin, cyclophosphamide, and ifosfamide/etoposide.
A list of current clinical trials is at: http://www.Cancer. Gov/clinicaltrials/search/results? Protocolsearchid=6293871&vers=2 good luck. ...Read more
Fundal uterine fibroid not responding to hormone treatment (not shrinking)
— injections 6months — concerns of sarcoma — will sarcoma show on MRI?
Very very unlikely: Unfortunately gynecological oncologists and radiologists have not found an accurate imaging technique to diagnose a uterine sarcoma which is very unlikely to "show on MRI". The lack of response of "your fundal uterine fibroids to hormone treatment" is not a reliable sign either. Consult an experienced gynecologist about uterine fibroid biopsy or a laparoscopic myomectomy if you remain "concerned" ...Read more
Can you tell me what is the best treatment for ewing sarcoma cancer affecting upper limb of left hand?
Multidisciplinary: Ewing's sarcoma is extremely serious and the treatment protocols are elaborate and the subject of intense scrutiny. Treatment will need to be individualized by a team of surgeons, radiation physicians, and oncologists. I hope that a good outcome results. Best wishes. ...Read more
Can you tell me some odd cells that were on the tumorthey called it sarcoma. What is going to happen next?
Need more info: It depends on many factors. First, is it a sarcoma of bone or soft tissue. Bone sarcomas usually get chemo, while it is variable for soft tissue sarcomas. It also depends on if the tumor had spread. In most cases sarcoma is treated with surgery. Talk to your doctor to get more answers. ...Read more
The largest published study to date (one institution) showed no increase in survival over conventional chemotherapy. However, this question is currently being evaluated in a collaborative clinical trial between europe and the us. See:
http://www.Cancer. Gov/clinicaltrials/search/view? Version=healthprofessional&cdrid=68608. ...Read more
3 irregular lobular mass with slight subcutaneous edema above massconcern for soft tissue sarcoma. Possibly synovial cell. What exactly does this mean?
Tuberous sclerosis have a large percentage of which of the following tumors? 1-renal cell carcenoma 2-adenoma 3-angiomyolipoma 3-oncocytoma 4-sarcoma
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