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Doctor insights on: Treatments For Paraproteinemia

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What causes monoclonal paraproteinemia?

What causes monoclonal paraproteinemia?

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive(more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more

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What causes paraproteinemia?

What causes paraproteinemia?

plasma cells: Paraproteins are abnormally produced immunoglobulins or immunoglobulin fractions made by overproductive and possibly malignant clones of plasma cells. This needs evaluation by a hematologist to determine if this is benign or malignant (cancer). ...Read more

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What are the consequences of paraproteinemia?

What are the consequences of paraproteinemia?

Varied: We have 3 entities which cause paraprotein production. The most benign is called MGUS which is often benign and the other two are Smoldering Myeloma and the most serious is called Multiple myeloma. You need to have your doctor explalin which of these conditions he/she thinks is causing this paraproteinemia. ...Read more

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How are benign and malignant paraproteinemia different?

How are benign and malignant paraproteinemia different?

Different causes: Malignant paraproteinemia is a harmful presence of a single kind of antibody, made by a known malignancy such as lymphoma or myeloma. Benign paraproteinemia is a harmful presence of a single kind of antibody in someone who has no such malignancy. It is presumably due to a benign clonal expansion of one type of lymphocyte. ...Read more

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What is the difference in benign and malignant paraproteinemia?

What is the difference in benign and malignant paraproteinemia?

Abnormal Proteins/My: Paraproteins are abnormal proteins which are often produced by Cancer cells unless proven otherwise. So it requires detailed testing looking for cancerous cell called Plasma cells in the bone marrow. There is one variant which may behave beningnly and is called monoclonal gammopathy of undetermined significance(MGUS). But some of the patients with MGUS do develop multiple myeloma,causing paraprot ...Read more

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Is monoclonal paraproteinemia the same thing as myeloma?

Yes in most ways: Myeloma is one of the differential diagnosis, the other condition is called mgus ...Read more

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Is there a cure medication to completely remove eradicate paraproteinemia from my blood stream its at 1.5 level im told.or is it incurable ?

Is there a cure medication to completely remove eradicate paraproteinemia  from my blood stream its at 1.5 level im told.or is it incurable ?

Hematologist: You need to consult a hematologist/oncologist for treatment. There are effective treatments using chemotherapy and the using person's own stem cells to correct the defect. Consult this site for info. http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more

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My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?

My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?

MGUS: Monoclonal gammopathy of unknown significance (mgus) is a very insidious disease. I do not believe that it worsens his prognosis or lifespan significantly. ...Read more

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Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Monoclonal: multiple myeloma (g>a>m>e, d) •primary macroglobulinemia (waldenstrøm’s, igm) •monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma) •miscellaneous conditions •(converts at 2% per year to myeloma) these all have to be thought of by the hematologist. ...Read more

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What are the symtoms of paraprotienenemia ?

What are the symtoms of paraprotienenemia
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None, but...: The presence of a monoclonal (para)protein in the blood (on spep) or urine (on upep) with or without an abnormal free light chain (flc) k/l ratio is a laboratory finding. This may be mgus (monoclonal gammopathy of unknown significance), myeloma, lymphoma, cll, etc. A few classic symptoms of myeloma are crab -- hypercalcemia, renal insufficiency, anemia, bone (lytic) lesions. Other sx possible... ...Read more