Doctor insights on:
Treatments For Aortic Sclerosis
Need chronically: Some advice, there are pills available, but where you live, might be tough to get. Nonetheless, do not miss your injections, and add Vitamin D-3 about 5000-10000 units per day. We do not have a clear idea when to stop the MS meds, and in those older patients who I have stopped, a few have had relapses. Stay tuned, drugs to be used differently are on the horizon. (even Lemtrada) ...Read more
D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist.
A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines. The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more
Not curable: The disease is managed by surgery for the tumors as applicable, and medications. No two cases are alike. Ask about sirolimus if this question applies to a family member. Patients who wish to become parents will do well to learn how to prevent transmission of the illness to their children. Best wishes. ...Read more
Managed, not cured: Ts is a lifelong process whose treatment begins with recognition, education and monitoring through life. It can be quite mild with no long term effects, or be devastating. Related seizures & emergence of soft tissue "tubers" in the brain & major organs can create problems. Periodic ct scans & ultrasounds to monitor the organs are common. Coordinated efforts of local & specialty drs is a must. ...Read more
Support/encourage: Aortic sclerosis is quite common as people get older, 25-30% in those>65 yrs of age. It is the calcification and thickening of the aortic valves without flow obstruction, but it a marker for athersclerosis/heart disease. Encourage him to take good control blood pressure, cholesterol, diabetes etc--take meds! . And don't smoke. Regular exercise, keep ideal body wt. Consult doc regularly. Good luck. ...Read more
For someone who is 40 years old, what are the long term detrimental impacts of interferon treatment for multiple sclerosis?
Interferon: The real question you should be asking is "what are the detrimental effects of not taking interferon for treatment of ms". Ms can be a deadly disease and medications are chosen and recommended by physicians after a careful consideration of risks versus benefits. Ask the prescribing physicians for information that will help you look at both sides of this issue. ...Read more
Getting exciting: Original meds included self-injectables, such as betaseron, avonex, compaxone, and rebith. Later, tysabri (natalizumab) infusions, and 2 oral meds, Gilenya and aubagio. We now know that vitamin d supplements provide added benefit. No one med fits all, but most effective drugs currently are Gilenya and tysabri (natalizumab), and these work best of the current crop. ...Read more
No unique answer: MS has many forms, many phases, individuals respond in all sorts of different and at times unpredictable ways so there is no BEST drug to tell you about. Latest research suggests the use of interferons and immunomodulating drugs is what best manages this disease. Unfortunately, there are plenty of problems with that approach but your doctor will discuss all the options with you. ...Read more
First line therapies include:
-interferon beta-1a (avonex) im once a week.
-interferon beta-1a (rebif) sc three times a week.
-interferon beta-1b (betaseron, extavia) sc every other day.
-glatiramer acetate sc (copaxone) sc daily.
Second line therapies include:
-mitoxantrone (novantrone) IV q3months.
-natalizumab (tysabri) IV q4weeks.
-fingolimod (gilenya) PO daily. ...Read more
Not really: It might be a fond hope to find such, but, if one has ms, treatment with disease modifying items is very important, and, in most cases, the most potent drugs are best. You can improve outcomes with supplements of vitamin d-3, perhaps b complex, low fat diet, exercise, and stress management, but these approaches do not replace the medicines. ...Read more
All are permanent: All treatments for MS are not curative, in order to stop or slow down the progression of the disease, you have to take them indefnitely. I hope this answers your question, not sure what you mean by permanent. If you mean that the treatments "permanently" stop progression, only possibly if you keep using them. I like tysabri (natalizumab) despite the side effects. I see MS lesions literally disappear. ...Read more
Many: We have 12 drugs approved to treat MS, and more on the way. The newest are Tecfidera, Plegridy, and the most potent drug of all, Lemtrada. Coming are newer mono-clonal antibodies, a drug to restore myelin damage, and even some treatment for the progressive forms. ...Read more
Complex: We do not know the exact cause of this autoimmune disease that attacks brain and spinal cord, but do find that both heredity and environment play roles in susceptibility. We are gaining new medicines which are far more potent (altho maybe risky), which can control the disease far better. The most potent available include tysabri (natalizumab) and gilenya. No cure yet, but stay tuned, it is close. ...Read more
My opinion: For what it's worth, each ms patient is unique and not all meds fit each person. Yet, you want a potent effective medicine, and nowadays we have lots of choices. Must consider risks and side effects. Most effective meds in descending order would be tysabri, (natalizumab) gilenya, tecfidera, rebif, betaseron, aubagio, copaxone, and lastly avonex. No perfect med exists commercially.. ...Read more
Autoimmune: Ms is a disease where the immune system attacks the coverings of nerves in the brain and spinal cord. Susceptibility due to heredity and environment seem to affect who gets afflicted. The prognosis is improving dramatically these days due to new medicines. Therapies include tysabri, (natalizumab) gilenya, copaxone, betaseron, rebith, extavia, etc. ...Read more
How can putting off treatment of multiple sclerosis by a few months after initial diagnosis (because of a temp. Loss of insurance) impact prognosis?
My experiences: Every MS patient is different, and experiences a varied and unique disease presentation, but we strongly suggest starting disease modifying agents as soon as diagnosis is confirmed to prevent disability. That said, delay of a few months may be trivial in your case, but, drug companies have programs for those without insurance, and no real reason to delay treatment. Discuss with your neurologist. ...Read more
Had an echo that stated "essentially normal". Said my three aortic leaflets are mildly thickened but open well. Isn't that considered aortic sclerosis?
Yes: What the reader might have meant was that "there is no hemodynamic adverse effect" as a result of "mildly thickened" trileaflet aortic valve. But, yes, you are correct is making the connection to early atherosclerosis = sclerosis. Consider checking your fasting lipid levels and embarking on a heart healthy lifestyle if you have not already. ...Read more
Not good: Lou gehrig's disease remains resistant to successful treatment or control. The drug Riluzole is on the market but is very disappointing, although may delay useage of a tracheostomy tube for a few months. We are learning about a misfolded protein, and this may point the way for future success. ...Read more
Hope it arrives.: There is a lot of research and we have identified a misfolded protein as playing a role (superoxide dismutase). But we do not have a cure. Best we can do is Riluzole and palliative supportive care at this time. However, a variety of meds and approaches are being studied. Stayed tuned. ...Read more
Depends: For early stage disease, it's usually 2-4 cycles abvd w/ involved site radiation. For advanced disease, it's at least 4-6 cycles of abvd or even beacopp with radiation reserved for sites of bulk disease. For relapse, new drugs like Adcetris (brentuximab vedotin) are in use as are the option of transplant. ...Read more
Try this: Although no cure currently, the drug Riluzole has been used to slow down the process and prevent or delay tracheostomy. Some pts might benefit from other glutamate blockers, Gabapentin and memantine have been tried in addition. Some alternative health sites have mentioned anti-oxidant approaches, and you might check hsi (health science institute). Get second opinion at nearby medical schools. ...Read more
How is the treatment for multiple sclerosis? Will my tinnitus (caused by multiple sclerosis) go away after I treat it?
Hard to predict.: If you have Multiple Sclerosis, you should be using specific MS medication, and do NOT understand why you are using ginkgo, which is totally useless for any neurological disease. Tinnitus may be due to inner ear issue and best to evaluate using audiological/ otological testing. ...Read more
26f healthy resting hr is 130-155. 2 dr tellme it's nothing to be concerned about. Echo showed mild aortic sclerosis. Dr said no worry. Should I be wryd?
Heart rate too fast: If your resting heart rate is that fast something is amiss, you need to get someone to figure it out. It could be dangerous. ...Read more
Possible: Aortic sclerosis is thickening of the valve leaflets which occurs naturally as people get older. It certainly can start showing up as early as 40s but is it also possible that whoever read your echocardiogram may have made note of something very minimal. Either way it is a benign issue that is different that aortic stenosis and may or may not progress. ...Read more
Not available: Closest approach to stem cell, so far, is bone marrow transplant, which has significant risk, and may be only minimally successful. Best approach in the relapsing-remitting phase, such drugs as Gilenya and tysabri (natalizumab). Some usage in chronic phases of rituxamab, but risks there also. Stem cell applications still a long ways off. Sorry. ...Read more
Facet syndrome: Core strengthening and stretching dailyGet a more detailed answer ›
I have lichen sclerosis, my treatment from the doctors doesn't seem to be working, how can I get rid of it?
Lichen Sclerosis: Ls&a (lichen sclerosis et atrophicus) is generally treated in the short run using high potency topical steroids such as clobetasol ointment. Protopic ointment is often used as an alternative to topical steroids for long term management. Consult a dermatologist to confirm the diagnosis and for further management. ...Read more
In a spinal tap - say, prior to beginning a new treatment for multiple sclerosis - will cocaine from past use be detected? If so, for how long?
Talk to your doctor: This is certainly not in my area of expertise. Generally, drug testing is done with urine or blood. I am concerned that you may be worried about some past behaviors - probably needlessly. It would be sad if this worry delayed your getting treated appropriately for your current condition. Have a frank discussion with your doctor. Start with "this is awkward for me to ask, but..." Good luck! ...Read more
Tuborous sclerosis. Which insurance covers laser treatment for angiofibromas? Best treatments for angiofibromas? Laser treatment is ineffective.
Angiofibromad: There are three main types of treatment for juvenile nasopharyngeal angiofibroma: hormone therapy, radiation therapy and surgery. Hormone therapy involves the use of a drug called flutamide, which acts by blocking testosterone receptors. The activity of this drug is further evidence for a hormonal cause for the condition. Treatment with Flutamide can shrink tumors by more than 40 percent. ...Read more
You Bet There Is!!: First, you are better if taking a very potent ms medicine, such as tysabri (natalizumab) or gilenya, as "off label" both have shown ability to prevent brain atrophy, and improve fatigue and cognition. Second, have adequate levels of vit d, taking 5-10000 units daily. The traditional Alzheimer's meds do not help usually, but would consider a trial of 2 medical foods, axona, and cerefolin-nac, and? Galantamine. ...Read more