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Doctor insights on: Treatment Trait Thalassemia

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Does alpha thalassemia trait have gene therapy available?

Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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Dr. Michael Engel
272 doctors shared insights

Thalassemia (Definition)

An inherited condition characterized by severe anemia (a deficiency of red blood cells), ...Read more


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What is thalassemia and thalassemia trait?

What is thalassemia and thalassemia trait?

Cooley's Anemia: Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the disorder results in excessive destruction of red blood cells, which leads to anemia. Thalassemia trait is a genetic possibility you pass on to your offspring. The most important reason for discovering if you carry the thalassemia trait is this: if two people who each. ...Read more

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What is trait thalassemia?

What is trait thalassemia?

Ok: Thal trait is different from thal major--the trait has one chromosome for this disease and the full disease means each parent gave the trait and that the child got a thalassemia gene from each parent which can cause thal major, a very serious and transfusion requiring process. There are different types of thalassemia--some more concerning than others. Please ask your doctor. ...Read more

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

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Sickle trait is a recessive gene?

Sickle trait is a recessive gene?

basically yes: The mutation that causes sickle cell disease is a recessive mutation in that you need two copies of the changed gene to have the disease (or one copy plus another mutation on the other gene like beta thalassemia, hemoglobin c, hemoglobin e, etc). If you only have one copy, you have sickle cell trait. ...Read more

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Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more

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Is sickle-cell anemia a recessive, sex-linked trait?

Is sickle-cell anemia a recessive, sex-linked trait?

Yes and no: Sickle cell disease is recessive; you need to inherit a sickle gene from both parents to get the disease. It is not x-linked, however; if it were it would affect only boys. Boys and girls are equally affected by sickle cell disease. ...Read more

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What is the alpha thalassemia trait?

What is the alpha thalassemia trait?

Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more

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What is sickle cell trait and anemia?

What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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Cure for thalassemia?

Cure for thalassemia?

Marrow Transplant: Currently the only way to "cure" thalassemia is to replace enough of the marrow cells that make red cells/ hemoglobin to result in normal oxygen carrying and delivery as well as reduced numbers of fragile red cells. And the only way to do this is by bone marrow transplantation. ...Read more

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Can a person wtih alpha thalassemia trait donate blood?

Can a person wtih alpha thalassemia trait donate blood?

Maybe: A person with Alpha thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more

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Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more

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Is thalassemia treatable?

Is thalassemia treatable?

By blood transfusion: In thalassemia patients who are very anemic, and have symptoms from their anemia, periodic transfusions is the usual treatment. If they have had many transfusions, their bodies will get iron overload from the past transfusions (chelation therapy to remove iron may be needed). The cure for thalassemia major is through bone marrow transplantation. ...Read more

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Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Help docs, is hemoglobin AC a sickle cell trait?

Help docs, is hemoglobin AC a sickle cell trait?

No: Hgb AC is a heterozygous genetic state that is not sickle cell trait ( Hgb AS). Patient's with Hgb AC are clinically well with at worst mild asymptomatic anemia (most are not anemic). Individuals with Hgb AC can have children with Hgb SC (a type of severe sickle cell hemoglobinopathy) if their partner has either sickle cell trait (25% chance) or sickle cell disease (50% chance) ...Read more

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Is there a cure for sickle cell trait?

Is there a cure for sickle cell trait?

No: And no cure is needed. With rare exceptions sickle trait has no impact on health and longevity. ...Read more

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How is thalassemia inherited?

From Mom and/or Dad: Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells. Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad. ...Read more

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