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Doctor insights on: Treatment Synovial Sarcoma

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What is the treatment for synovial sarcoma?

What is the treatment for synovial sarcoma?

Surgery foremost: There are conflicting results on whether radiation and/or any chemotherapy protocol helps at any particular stage. If the tumor has not spread to the lungs, for most patients a 5-year disease-free survival is more likely than not. Unoperated, the disease is lethal. Good luck, and thanks for asking. ...Read more

Dr. Al Hegab
2 doctors shared insights

Sarcoma (Definition)

By definition, it is malignant (i.e., being locally invasive and at least theoreticlally capable of metastasizing), and arises from / mimics muscle or connective tissue elements that are not marrow or immune / white cells. The sarcomas are a tremendously varied and troublesome family of tumors, though thankfully less common than carcinomas and the leukemia / ...Read more


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What is the best treatment for synovial sarcoma?

What is the best treatment for synovial sarcoma?

Still under study: Everyone agrees that surgery is foremost. Whether local radiation and/or adjuvant chemotherapy (and if so what kind) are helpful is still up for grabs, with different studies giving different results for different stages of tumor. Unless the disease has spread to the lungs, the chances of long-term survival are generally better than even. Good luck. ...Read more

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Are there any treatments for synovial sarcoma?

Yes: Treatment of synovial sarcoma is centered on surgical removal of the tumor with a cuff of normal tissue around it (medical term is wide resection). Radiation is given either before or after surgery in many cases. Use of chemotherapy is controversial as it gives a minimal improvement in survival rates at best. Chances of cure are about 60-70% overall, but every case is different. ...Read more

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Have had a back pain to the left side of the right scapula. Isn't constant. Will flare up and go away. Someone I know has Synovial Sarcoma. Not me! =/?

Have had a back pain to the left side of the right scapula. Isn't constant.  Will flare up and go away. Someone I know has Synovial Sarcoma. Not me! =/?

Cancer is constant: Cancer pain is constant and persistent. Among the possibilities: Muscle strain, rib facet syndrome, pleurisy if it coincides with breathing. These are benign and self-limited. Stay healthy and active. ...Read more

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How serious is synovial sarcoma?

How serious is synovial sarcoma?

It's a cancer.: Synovial sarcoma is a rare cancer that arises near joints. Despite the name synovial, referring to the lining of joints, it almost never arises within a joint. Surgical removal is the mainstay of treatment. Radiation is often added to lower risk of it growing back. It is controversial if chemotherapy helps. While the majority of people are cured, it can be a deadly disease. ...Read more

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What are the symptoms of synovial sarcoma?

Growing mass : Synovial sarcomas tend to occur close to joints. They present as a lump which may grow, either quickly or slowly. Unlike other sarcomas, which are painless, synovial sarcoma may be painful. The name synovial is a misnomer. Synovium is the lining membrane of joints, but synovial sarcomas occur near, not in joints and have nothing in common with synovium. ...Read more

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What are the chances of one surviving synovial sarcoma?

>50% likely cure: Assuming the tumor has not metastasized to the lungs, a majority of patients with this cancer enjoy long-term survival with today's treatments, which are evolving. Since synovial sarcoma has a trademark genetic defect, a specific "magic bullet" may be discovered as has happened for similar cancers. I admire your courage and wish you luck. ...Read more

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Is synovial sarcoma a serious cancer?

Is synovial sarcoma a serious cancer?

Very: It will invariably kill if it is untreated. If it has spread to the lungs, we presently have no cure. If it has not, with today's therapy (surgery; the value of radiation and/or chemotherapy, depending on the stage of tumor and type of treatment) more than 50% of patients survive 5-years, the majority of these disease-free. Good luck. ...Read more

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What is the survival rate with stage 4 synovial sarcoma?

I know of: No curative treatment for metastatic synsarc. If interval from DX to mets is short, that's worse. If long, and to lungs, some optimism of pulmonary met resection. I'm sorry for being so blunt. Unfortunately, I'm being quite honest. ...Read more

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For a synovial sarcoma are imatinib or everolimusm effective?

For a synovial sarcoma are imatinib or everolimusm effective?

These have no: Established role in front line therapy. Are they being offered on a clinical trial? Both are costly, and possibly of theoretic use. Ask for the strength of the data (it will be called a phase ii trial),. ...Read more

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What should I know about synovial sarcoma and is it a serious cancer?

What should I know about synovial sarcoma and is it a serious cancer?

Can be: A rare form of cancer which usually occurs near to the joints of the arm, neck or leg. Synovial sarcoma occurs most commonly in the young, representing about 8% of all soft tissue sarcomas. Primary treatment for synovial sarcoma is surgery to remove the entire tumor with clear margins when possible. Treatment can involve chemotherapy and radiation. Localized disease has about 70% five-year survial. ...Read more

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If you have synovial sarcoma how would you know? Would you feel a lump?

If you have synovial sarcoma how would you know? Would you feel a lump?

Maybe: Synovial sarcoma is a diagnosis made by microscopic evaluation of biopsied tissue and special stains of tissue and possibly markers done on flow cytometric studies. You may feel an irregularity or bump, depending on the size of the questionable area. Put your mind at ease and be seen by your doctor. ...Read more

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What does it mean to have synovial sarcoma?

It's a cancer: It usually occurs in the soft tissues near joints. Unlike other soft tissue sarcomas, that are painless, it can be painful. It is treated with surgery and radiation. Use of chemotherapy if the tumor hasn't spread is controversial. If the cancer spreads, it usually goes to the lungs. With proper treatment, chances of survival are quite good. ...Read more

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Any docs familiar with synovial sarcoma? What can you tell me about it?

Sarcoma specialist: As per NCCN guidelines, patients should be diagnosed and managed at a multidisciplinary sarcoma center when possible. If tumor is localized, surgery and radiation are recommended with chemotherapy generally reserved for patients with intermediate or high grade tumors larger than 5 cm. Chemotherapy is the mainstay of therapy for patients whose tumors have spread. ...Read more

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What are the current immuno-therapies for synovial sarcoma? How effective are them?

Experimental: Despite "pop" claim and excitement, immunotherapy has historically been a bust for sarcomas. There 's some new stuff but it'a way early. There is a melanoma-sarcoma group at Sloan Kettering; Dr. D'Angelo may have something. Good luck. ...Read more

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What are the symptoms of synovial sarcoma in the back of knee?

What are the symptoms of synovial sarcoma in the back of knee?

Swelling: Synovia Sarcoma is one of rare forms of sarcoma usually developing in the knee region. It is slow growing often leading to a delay in dx. With incomplete removal recurrence is common. Half of the cases metastasize. The most common symptom is swelling or a mass that may be tender or painful and mistaken for inflammation of the joints, Wide resection essential. ...Read more

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How bad is it if one lymph node is postive after synovial sarcoma removal from left calf?

IIt is not: A common dx, unlike its name, does not always occur at joints, but is lumped as a "soft part sarcoma" so it can metastasize to lungs, but unlike many sarcomas, it can also travel to lymph nodes. Resection free margins is key. Even 1 node conveys higher risk of relapse. ...Read more

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What are the current targeted gene therapies for synovial sarcoma? How effective are they?

What are the current targeted gene therapies for synovial sarcoma?  How effective are they?

Very early : Nothing is standard. Phone the folks at the National Cancer Institute and see if you can get into a study. Even if it does not help, you have advanced scientific knowledge for the next person. ...Read more

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Which is the better adriamycin (doxorubicin) or ifosfamide for synovial sarcoma?

Which is the better adriamycin (doxorubicin) or ifosfamide for synovial sarcoma?

Usually combined: These 2 chemotherapy drugs are usually combined in treatment of synovial sarcoma. I am not sure that one is better than the other. A study in the 1990s showed that the combination was better than doxorubicin alone. ...Read more

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I have a Tumor growing out of my joint in my left shoulder iv had an MRI and it's say they can't rule out synovial sarcoma and since the MRI 3 months a?

I have a Tumor growing out of my joint in my left shoulder iv had an MRI and it's say they can't rule out synovial sarcoma and since the MRI 3 months a?

Question?: What is your question here? Have they done a biopsy? I know this is worrisome for you. Remember that you have right as patient to ask and see the MD who ordered the MRI in order to get all questions answered! ...Read more

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If someone had synovial sarcoma in the back of their knee would you feel a lump or something for sure?

If someone had synovial sarcoma in the back of their knee would you feel a lump or something for sure?

Palpable mass: Synovial sarcomas present as a mass in the region of a joint. The ankle and popliteal space (knee) are common sites for lesions to appear. When a mass is noted, scan needed for extent of involvement. Then bx required and if sarcoma defined, radical resection with margins required. This would then be followed by RT. If primary resection successful, cure rate high. ...Read more

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I was diagnosed Cancer(Synovial sarcoma) and done with BK amputation so after 6months present reports are fatty liver infiltrarion grade 2! What should I do!!??? Is it something risky?

I was diagnosed Cancer(Synovial sarcoma) and done with BK amputation so after 6months present reports are fatty liver infiltrarion grade 2! 
What should I do!!???
Is it something risky?

Need more info: If you do indeed have NAFLD, I don't think it has anything to do with your surgery. I need to know what medications you are taking, Methotrexate, valproate, and glucocorticoids can cause NAFLD. Avoid alcohol and hepatotoxic drugs, and lose weight if you are obese. Talk to your doctor for a thorough evaluation and confirmation of the imaging report. ...Read more

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Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Chemotherapy for SS: I would potentially seek out an opinion from the mayo clinic oncology department who are not very far north of you. I can help set that up for you. Please contact me at David.stockman@orthopath.com ...Read more

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I was told yesterday that I have 2 fibroids in my uterus wall. What are the chances of the fibroids turning cancerous, I have had synovial sarcoma bef?

I was told yesterday that I have 2 fibroids in my uterus wall. What are the chances of the fibroids turning cancerous, I have had synovial sarcoma bef?

Congrats on : Your success with synovial sarcoma. Fibroids almost never 'convert' to cancer, but can be an associated cause of infertility and dysfunctional uterine bleeding. There are ways of ablating the fibroids without hysterectomy. Fibroids are very common. Celebrate your success and do not worry about these unless symptomatic or an issue with wanting to be preganant. ...Read more

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I had synovial sarcoma can it spread to your ovaries I have already had surgery and chemo. But they only scan my lungs to see if it has spread every 4 months. I have pain in my left and right abdominal area have to pee all the time. Bloated. I have had a

Given : Given your medical history, the most reasonable thing to do would be to consult your oncologist about your symptoms so that you can have a complete evaluation. With a complicated past medical history, that is the best course to take. ...Read more

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3 irregular lobular mass with slight subcutaneous edema above massconcern for soft tissue sarcoma. Possibly synovial cell. What exactly does this mean?

3 irregular lobular mass with slight subcutaneous edema above massconcern for soft tissue sarcoma. Possibly synovial cell. What exactly does this mean?

Soft tissue sarcoma: The imaging findings are concerning for a soft tissue sarcoma or other aggressive process. You should be evaluated by an orthopedic oncologist or at a sarcoma center. ...Read more

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How serious are synovial and tarlov cysts in the low back? And will they get bigger? What is the best treatment? Thanks

How serious are synovial and tarlov cysts in the low back?  And will they get bigger? What is the best treatment?  Thanks

Let me explain: Tarlov cysts are defined as cysts formed within the nerve-root sheath at the dorsal root ganglion. The etiology of these cysts is not well understood; most common in the lower spine. They could cause some problems.
The etiology of lumber spine synovial cyst is still unclear, most of them with arthritis of the spine. They are not serious problems. ...Read more

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What's sign symptom synovial leak under vastus laterasis, gluteus medius. Treatment for this, had hip arthroscopy, capsule left open. 9 weeks ago. Thanks?

What's sign symptom synovial leak under vastus laterasis, gluteus medius.  Treatment for this, had hip arthroscopy, capsule left open. 9 weeks ago. Thanks?

Second opinion...: I'm curious as to why you have had 3 hip scopes? What is your original diagnosis? If your capsule was left open the you should expect synovial fluid to leak into the soft tissues. If you have had 3 surgeries by the same surgeon and still have problems then I would get another opinion. ...Read more

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Pimple-like eruption on my second toe — synovial fluid? Previously treated with steroid injection — it's back — treatment?

Pimple-like eruption on my second toe — synovial fluid? Previously treated with steroid injection — it's back — treatment?

Sounds like: A mucous cyst. These are small cysts over a joint which is filled with synovial or joint fluid. Steroid injections may help. In recurring or painful ones, sometimes surgery which includes addressing the affected joint is necessary. See Podiatrist for examination and discussion. ...Read more

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Do soft tissue sarcomas such as synovial sarcomas usually bruise? I have a lump with a large bruise diagnosed as broken vein/vessel. Scared of cancer.

Do soft tissue sarcomas such as synovial sarcomas usually bruise? I have a lump with a large bruise diagnosed as broken vein/vessel. Scared of cancer.

Any Cancer can bruis: The only way to remove your scared feeling is to get this lump biopsied or removed and check it out under the microscope. Your doctor can guide you further as to how to monitor and resolve your fear ...Read more

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