Doctor insights on:
Treatment Of Prothrombin Factor 2 Gene Mutation During Pregnancy
My partner has ulcerative colitis and prothrombin gene mutation, is it possible these conditions are linked?
No: They are likely unrelated.Get a more detailed answer ›
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
A gain of function mutation of the prothrombin gene results in higher levels of prothrombin, a clotting factor, and predisposes the person to forming clots in blood vessels. You may consult this site for more info: https://www. Healthcare. Uiowa. Edu/labs/lentz/Information_For_Patients/PDF/Prothrombin%20Gene%20Mutation%20Brochure. Pdf
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more
What is a prothrombin gene mutation? It is something worth worrying about whether you have it or not?
PGM: Prothrombin gene mutation is an inherited coagulopathy. This means that if you have this gene mutation, you can be at increased risk of forming clots in certain veins in your body. These clots can be dangerous and even lead to death. We do not routinely check for this mutation but do order this test if a young patient develops a deep blood clot. ...Read more
I have prothrombin gene mutation g20210a, I'm pretty sure I follow under a vitamin defect. Is their anything I can do?
Prothrombin G20210A: Prothrombin is the precursor of thrombin in the coagulation pathway; it is synthesized in the liver, much as other vitamin k – dependent proteins are. The prothrombin gene is found at 11p11-q12) on chromosome 11. mutation at position 20210 of the gene results in thrombophilia. This coagulopathy is more likely to cause venous thrombosis rather than arterial disease. Is not related to a vitamin deficit. Coumadin (warfarin) is the treatment of choice. You seem to be in the hands of a good hematologist. I am truly sorry to hear about your stroke. I can understand your concerns as I also suffer from three clotting factor disorders and am on coumadin (warfarin). Best wishes for a happy and healthy new year. ...Read more
Is cancer my next battle? After stroke, dvt, p.E. I have prothrombin gene mutation g20210a. I'm currently cancer free but what are my odds?
Why do you ask?: You have given me no reason to believe that you have cancer. The cancer that's most famous for causing thrombi -- common pancreatic cancer -- would be very rare at you age of 29. I suspect you have some additional unknown cause of hypercoagulable blood and need to stay under the care of a good hematologist. If you do develop a mass or new symptoms, get seen, but don't let fear ruin your life now. ...Read more
I have prothrombin gene mutation g20210a, I've had a p.E & DVT & stroke in the past 2 years. Cancer runs in the family, but I'm currently cancer free?
What's your question: We'd all like to help, but you haven't made clear what you're asking. I'm glad you're being treated after your thrombotic events. If you can let us know exactly what we can do for you, please resend your question. ...Read more
Pregnancy mutations: Conception is a function of two sets of chromosomes, 22 + X from an egg and 22 + X or Y from a sperm. The resultant combination goes through a "re-mixing"_ process that requires pairing the chromosomes with subsequent "detachment" If the detachment process is not a complete "pair", then gene mutations occur especially in women older than age 37. ...Read more
I asked about thanataphoric dysplasia & I understand it is a new gene mutation, but what is its risk of recurrence in following pregnancy?
Testing: If neither parent is affected by achondroplasia then this is most likely a de novo mutation in the FGFR3 gene. This means clinically that the risk of recurrence is not higher than the baseline risk for everyone (1/20, 000). Mosaicism (carrying gene but not expressing) by testing the parents DNA through targeted molecular genetic testing. ...Read more
Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?
Controversial...: Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes! ...Read more
Do all mthfr gene mutations benefit from folate over folic acid? Or certain stands? Is there different treatment for heterozygous v homozygous?
MTHFR has several forms. And treatments can vary.
Look here for additional information.
http://mthfr. Net/mthfr-c677t-mutation-basic-protocol/2012/02/24/ ...Read more
Mom feels great from Tarceva. When will it stop working? Any 2nd-line treatments out there? Tested neg. For other genetic mutations except 20% PDL1.
20y o woman, have thrombophilia factor vii (7) heterozygote gene mutation, I have had 7week miscarriage, is thromb. The cause? I am very healthy
I am on Coumadin (warfarin) for life for a dvt/pe where they found a factor 5 gene mutation. Is there any alternative to Coumadin (warfarin) that will allow me greens?
No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting). ...Read more
Separate study: If you are having the one study done it is simple enough to arrange for the other study at the same time. They are separate tests and often done at a separate lab. ...Read more
Hi, I'm not really sure how this service works, but I'm going to send my question and see what happens. I have been having fertility treatment and was recently diagnosed with the homozygous C665T MTHFR gene mutation. There is a lot of conflicting inform
Cannot offer more help than this:
The "story" is still "OUT" and this gene abnormality has now been blamed for just about EVERYTHING from early heart disease to frequent miscarriages! I would be VERY CAUTIOUS about accepting ANY ADVICE particularly the INTERNET about this "condition" If this is a MAJOR issue consult with a Board Certified GENETICIST! My Opinion only...hope it helps. Good Luck Z ...Read more
I have a mutation of the mthfr gene and have had a thermal ablation. I have had 4 pregnancies and lost them. Uterine lining is 3.74 can I carry a baby?
MTHFR Gene mutation: Here's some important information on the mthfr gene mutation... http://doccarnahan. Blogspot. Com/2013/10/whats-big-deal-about-methylation-update. Html. ...Read more
If I have the double gene mutation (homozygous) for hemochromatosis but am not clinically iron overloaded (have high iron levels on lab results) at this time, can I develop iron overload later, such as in 2, 5, or 10 or more years later?
Hemachromatosis: The single gene carrier will likely not develop any symptoms or problems from increased iron absorption. You will still need to have regular blood work to check for increased iron, and not use any supplements with iron. If you have two genes, your chance is good that you will have high levels of iron, and possibly get damage from the extra iron. Timing is unknown, too many variables. ...Read more
Both or neither.: While neural tube disorders can be a genetic mutation (gene is a functional unit of heredity occupying a specific spot--locus--on a chromosome), they occur most commonly in the setting of Folic Acid deficiency during pregnancy--hence prenatal vitamins with folic acid. Ntds occur in 1/1000 births, and range from spina bifida occulta to anencephaly. ...Read more
Yes and more: Neural tube defects can be brought on by genetics, nutrition, and environmental factors. Women who are deficient in Folic Acid before or during pregnancy are at a higher risk for neural tube defects. Women who are obese, have poorly controlled diabetes, or take medication such as Dilantin, Tegretol, or Depakote are at higher risk for neural tube defects or anencephaly. I hope this helps. Take c ...Read more
Can genetic testing be done USING SPERM, to tell if that sperm contains any de novo single gene mutation or any other types of mutation?
Hard to see value: You would have no guarantee any other sperm would have a that or a similar mutation. It could never survive the testing and be used to create a pregnancy if it were "good".The benefit of having so many sperm released during intercourse is the healthiest ones are able to swim faster and fertilize first. ...Read more
I have blood clotting prothrobin gene mutation 20210a on walfarin and have birds nest ivc filter, filter has moved and 2wires broken is this danger?
Generally no: Filters can fracture and break but they generally don't completely dislodge. Unfortunately that doesn't give you a lot of comfort knowing that if is is not completely blocking then clot can continue. Your doctor may discuss with you filter placement proximal to current, removal and continue blood thinner. ...Read more
I have been worrying if the food I eat may cause spermatogonial stem cell to have gene mutation defect, affecting my future sperm even aftermany years?
Mutations: A chromosome will contain many genes, so a chromosome mutation will effect many genes. A gene mutation will have an effect only on that gene. ...Read more
Size: Chromosomes are the large packages containing the genes, usually changes in the genes are called mutations and changes in the chromosomes are copy number variations or changes involving gain or loss of chromosome material ...Read more
Neural tube defects: Neuraltubedefect is multifactorial. Common association is fic acid deficiency. ...Read more
Could taking benzodiazepines by a man regularly before conception cause a single sporadic gene mutation in the fetus?
No: Male gametes are genetically programmed early on in life. ...Read more
When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more