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Doctor insights on: Tpa Medication

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Dr. Ali Razmara
55 Doctors shared insights

Tpa (Definition)

T-PA is a clot buster which is a kind of ...Read more


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How effective is t-pa for a 90 year old suffering a stroke?

How effective is t-pa for a 90 year old suffering a stroke?

Might help: When thromboplastin activator first appeared it was felt dangerous for elderly pts, and only safe if used very early. All of this is now modified and it may be both safe and effective in older pts if additional risk factors are not present. However, still most effective if used as early as possible. ...Read more

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How effective would t-pa be for a 95 year old with a stroke?

How effective would t-pa be for a 95 year old with a stroke?

Opinion: You may find a variable amount of opinions but from a neurosurgeons perspective, the risk is too high to give tpa (alteplase) to a 95 year old with a stroke. Someone needs to have a frank discussion with the family regarding proper treatment for patients of a certain age. The tpa (alteplase) may work great, but the risks of hemorrhage or other life threatening complications is high. ...Read more

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What should be monitored before administering the tpa (alteplase)?

What should be monitored before administering the tpa (alteplase)?

Complicated: You need to check it with your physician since it depends on many parameters, but generally speaking: head ct, blood pressure, age, time onset of stroke, coagulant estate and use of anticoagulation, history of previous stroke, bleeding and recent surgeries.... ...Read more

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What is tpa, (alteplase) and why is it important in stroke?

What is tpa, (alteplase) and why is it important in stroke?

TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more

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What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

Depends: This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase).
It also depends on how long the symptoms have been occurring.
But to answer your question, theoretically all could potentially benefit. ...Read more

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What is the age limit for being given tpa (alteplase)?

What is the age limit for being given tpa (alteplase)?

Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more

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What is the age limit for being given tpa (alteplase)?

What is the age limit for being given tpa (alteplase)?

Used to be rigid: Used to be arbitrary age which I believe was 75 and now is individualized. ...Read more

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Why don't stroke patients get tpa (alteplase) therapy?

They can: If having a stroke one can receive intravenous tpa (alteplase) up to 3 hours once symptoms begin and up to 4.5 hours in certain cases. After this intra. ...Read more

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Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more

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Tpa (alteplase) fail & they wait to do surgery until family is located. Too late by then for surgery. Er dr couldn't do surgery cuz he didn't have informed consent.?

Tpa (alteplase) fail & they wait to do surgery until family is located. Too late by then for surgery. Er dr couldn't do surgery cuz he didn't have informed consent.?

Not nessecarily: It depends on the situation and the emergent nature of the procedure needed. It is always preferred, to have informed consent prior to doing anything, but under certain situations/emergencies a life saving procedure can be performed even if informed concent is not possible. ...Read more

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Docs, could a patient be given tpa (alteplase) when on antiplatelet therapy?

Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more

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How much time to hold tpa (alteplase) if a patient had stroke and is on dabigatran therapy?

No TPA (alteplase): Dabigatran is an absolute contraindication to TPA (alteplase) use. The stroke patient in question is not a candidate for TPA (alteplase). ...Read more

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Is tpa (alteplase) available to stroke patients in trinidad and how does it differ from aspirin?

Powerful Clot buster: Tpa (alteplase) is likely available in trinidad to help treat strokes (now sure, but likely at certain hospitals). It is a very powerful medication that helps to break up blood clots. It can be quite dangerous though, can cause serious bleeding and should only be used in certain life-treatening situations. Aspirin can also cause bleeding, but works differently from tpa (alteplase) in that it prevents clot from forming. ...Read more

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In icu. Left sided numbness pain weakness. Tpa (alteplase).All tests so far negative. All doctors no clue what's going on. Think stroke not sure. Any ideas?

In icu. Left sided numbness pain weakness. Tpa (alteplase).All tests so far negative. All doctors no clue what's going on. Think stroke not sure. Any ideas?

? migraine: An entity called hemiplegic migraine could present this way, and typically the process is reversible. Small stroke might be tough to see on certain types of mri's and a perfusion/diffusion approach might reveal. A series of tests to confirm your etiology might be useful. Neurology involvement is key here. ...Read more

Dr. Brian Santin
73 Doctors shared insights

Clot Buster (Definition)

Clot busters are a kind of ...Read more


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