Doctor insights on:
Intolerance: An undesirable/uncommon effect of Topotecan could be due to allergy. Most allergic reactions manifest as skin rashes which are generally itching and sometimes urticarial in nature. A sudden drop in BP after an initial few drops of medication would be very suggestive of an allergic reaction. Nausea/vomiting are an expected side effect of chemotherapy, so that would not be an allergy. ...Read more
Hopefully: I have seen many chemo agents over the past 20 years cause musculoskeletal problems. I must say that the majority of those problems such as pain do go away. The problem is there is no definite time frame. I have seen pain resolve within weeks to a year. You always want to make sure there is no other cause for the musculoskeltal complaints. Good luck. ...Read more
My mother was administered topotecan and is now suffering from severe worsening diarrhea and low WBC count. Medicines for diarrhea require wbc. Help!?
Ov cancer spread to lymph nodes. Paclitaxel, avastin, (bevacizumab) doxil, gemzar, topotecan have failed. Is it all down hill from here? Is this the end?
Not yet: Ovarian cancer can best be managed by minimal tumor burden an then intraperitoneal chemotherapy. If there is a well defined chain of nodes such as the iliac nodes, I do a pelvic node dissection. L if the tumor burden represents additional multiple nodules along the surface of the bowel, they must be reduced to smaller than 1cm. In diameter. In addition it is essential that the omentum is out. Ea. ...Read more
There are none...: Even the strongest opiates only "take the edge off" for people in chronic pain. Meds are only one part of dealing with the pain. A useful tool, but pain is so necessary for survival that we are not "allowed" to monkey with it much. In acute pain, the transition from miserable to less miserable can be great. In chronic pain, it's just part of the plan. ...Read more
Sometimes: Sometimes they are. For the most part, expired drugs simply lose potency once past their expiration date. There are, however, some drugs that actually become harmful if taken after they expire. As such, it is best to throw out any medications you have after a year. ...Read more
ASPRIN: Actually no one has decided on 'safest'. Asprin has been around since before you were born and unless you take too much (yes, too much of anything isn't good) most people are okay with it. If the pain it too severe for asprin you need to know what causes it. Good diagnosis is called for. See the dr. ...Read more
Applies to skin: Topical just refers to how a medication is applied. In this case to the skin and is meant to treat local skin problems. Some meds are applied to the skin but are meant to be absorbed into the body in which case we use the term "transdermal" since it is meant to pass through the skin to affect the whole body. ...Read more
Why R you depressed?: If your depression is affecting your life and/or those around you and you have trouble dealing with it or not knowing how to etc. It is very reasonable to seek help, either from a therapist, your physician/nurse, or both. Psychotherapy may be adequate for some, others may need both meds (many choices, depending on your symptoms/needs) and therapy. Consult doc. Good luck. ...Read more
RSD, or: Complex regional pain syndrome can be difficult to treat and each patient needs to be treated differently. Opioid medications are definitely not the first option. Consider medications that affect nerve pain most, like neuromodulators such as gabapentin. Clonidine has been found to help some as well. Stellate ganglion blocks can be diagnostic/therapeutic. Consider topical ketamine creams as well. ...Read more
Antacid: An h2 blocker (like Pepcid (famotidine) or its generic) once or twice daily, provides relief for many after about a week. If this fails, a proton pump inhibitor (ppi--like Prilosec or its generic) will often work where h2's have failed. If both fail after at least one week trial of each, see your dr or a GI dr for eval. ...Read more