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Doctor insights on: Topical Calcineurin Inhibitor

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Dr. Jan Lei Iwata
2 Doctors shared insights

Topical Calcineurin Inhibitor (Overview)

Topical calcineurin inhibitor is an immune system affecting agent..


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I heard that calcineurin inhibitors are not safe for eczema treatment. Is this true?

I heard that calcineurin inhibitors are not safe for eczema treatment. Is this true?

Use properly: Recently (1/2006) the fda placed a “black box” warning on these drugs. Both the american academy of allergy, asthma and immunology and the american academy of dermatology feel that this was an unfortunate and unnecessary decision, as these drugs are very safe when used properly. ...Read more

Dr. Jan Lei Iwata
2 Doctors shared insights

Topical Calcineurin Inhibitor (Overview)

Topical calcineurin inhibitor is an immune system affecting agent..


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I heard that calcineurin inhibitors are not safe for eczema treatment. Is this true?

Use properly: Recently (1/2006) the fda placed a “black box” warning on these drugs. Both the american academy of allergy, asthma and immunology and the american academy of dermatology feel that this was an unfortunate and unnecessary decision, as these drugs are very safe when used properly. ...Read more

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If u get a steroid tendon inj & r taking a cyp450 3a4 inhibitor at the same time is it like getting 3 steroid injections?

If u get a steroid tendon inj & r taking a cyp450 3a4 inhibitor at the same time is it like getting 3 steroid injections?

No: It is still one steroid injection. Biotransformation in liver is important for drugs given trough mouth, im and IV since those effect depend on concentration of drug in blood. Liver (and p450 enzyme system) has relatively little effect on drugs injected in joints, epidural space, tendons, body cavities. ...Read more

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Can you tell me what the ACE inhibitor is?

Can you tell me what the ACE inhibitor is?

Type of BP med: An ace inhibitor, or angiotensin-converting enzyme inhibitor, is a type of blood pressure medication to control high blood pressure. ...Read more

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Why do lipase inhibitors not stop 100% of the fat?

Why do lipase inhibitors not stop 100% of the fat?

Not enough amounts: Quantity and concentration related, and you get nasty foul smelling greasy stools. ...Read more

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Are 'aromatase inhibitors' healthy to take regularly?

Are 'aromatase inhibitors' healthy to take regularly?

Maybe but for what?: All medications, prescription & otc, as well as all dietary supplements, have potential side effects. There is no free lunch, no side effect free pill, whether medication or supplement. Aromatase inhibitors are approved for use in breast cancer in which case the potential risk of liver damage, hypertension, etc probably outweighs risk of recurrent breast cancer. So talk to your doc re what's right. ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful.

* (eyding d et. Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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Is atenelol an ACE inhibitor?

ACE or BB?: Not it is a BB. Happy to do 2nd opinion as specialize in high blood pressure for over 50 years. ...Read more

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What are ACE inhibitors used for?

What are ACE inhibitors used for?

Heart and kidney: Ace inhibitors are blood pressure medications used for blood pressure treatment. They also have effects independent of the blood pressure effect on the heart, particularly for people with heart failure, and on the kidneys, particulaly for people who have diabetic-induced kidney disease with protein in the urine. ...Read more

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What are lipase inhibitors (orlistat)?

Orlistat: Orlistat is lipase inhibiter and is used to loose weight in over weight individuals with low fat, low calorie diet and exercise. So fat is in not absorped in its entirity and is passed undigested in stools. ...Read more

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Any over-the-counter aromatase inhibitors?

No: There are no over the counter aromatase inhibitors. They are only available by prescription. ...Read more

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Is tamoxifen the same as aromatase inhibitor?

Is tamoxifen the same as aromatase inhibitor?

No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read more

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Has anyone tried carbonic anhydrase inhibitors?

Has anyone tried carbonic anhydrase inhibitors?

Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more

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Effect of ACE inhibitors making you feel calmer?

Effect of ACE inhibitors making you feel calmer?

No: There is a common misconception that calm people don't have hypertension and treating antihypertensives will calm people. Overall that is not the case. There may be one exception. Beta blockers block adrenaline which can make one feel calmer. Acei other antihypertensives usually do not result in people feeling calmer. ...Read more

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What medications are classified as ACE inhibitors?

What medications are classified as ACE inhibitors?

They end in -pril: Look at the generic medication name. If it ends in "pril" it's an ace inhibitor. Common ones: lisinopril, enalapril, captopril, ramipril etc. Their cousins, arbs end in "artan" as in losartan, irbasartan, etc... ...Read more

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Why pde5 inhibitor cannot taken with nitrate? Thanks

Why pde5 inhibitor cannot taken with nitrate? Thanks

Severe Interaction: This combination phosphodiesterase inhibitor (pde5) + nitrate has been shown to cause a drastic drop in blood pressure (hypotension) a medical emergence that can result to death. Really deaths have been reported with this combination. Pde5 (some drugs in this class include viagra, (sildenafil) cialis, levitra). ...Read more

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What are the side effects of pump inhibitor medcine?

What are the side effects of pump inhibitor medcine?

Few: Most common side effects are on the label or insert. Most are not common. You can find them on the web at sites such as pub med health. Watch for any drug interactions with your other medications. ...Read more

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What are the distinctions between ACE inhibitors and arbs?

Ace vs arb: They are drugs which block functions at different points in the same pathway. Ace blocks an enzyme and arb blocks a receptor, their effects are similar. It's something like either cutting a wire to a spark plug or damaging the plug itself. Either way you don't get a spark. ...Read more

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Is there a homeopathic alternative for aromatase inhibitors?

Is there a homeopathic alternative for aromatase inhibitors?

No: If you have been prescribed aromatase inhibitors, presumably you have hormone sensitive breast cancer. Do not substitute the homeopathic placebo for your medications. The data on breast cancer treatment is solid for aromatase inhibitors and using a homeopathic placebo might prove lethal. ...Read more

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Which is better, ACE inhibitor vs. Arb in layman terms please?

Which is better, ACE inhibitor vs. Arb in layman terms please?

Depends: Amer heart assoc recommends both. If you have diabetes, an ace inhibitor is a good choice since it may protect against diabetic kidney disease. You & your doctor should discuss alternative treatments for htn. If you have certain kinds of heart disease, then a beta blocker or diuretic may be a better choice. That's why it's best to discuss treatment with your doctor. ...Read more

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What are alternatives to serotonin reuptake inhibitors (ssris)?

What are alternatives to serotonin reuptake inhibitors (ssris)?

Several: Although ssris have been by far the most popular class of antidepressants for many years, there are several other options that focus on different systems. Wellbutrin is thought to work through dopamine; remeron, cymbalta, effexor, (venlafaxine) & others, also affect norepinephrin; and deprenyl and others are MAO inhibitors. Each has pluses and minues and may work when ssris don't. ...Read more

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When should someone take selective serotonin re-uptake inhibitors?

Depression: These medications are usually a first line medication for depression although they have other uses. ...Read more

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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

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Is it healthy to take an chrysin surge aromatase inhibitor as a teen?

Is it healthy to take an chrysin surge aromatase inhibitor as a teen?

No it is not.: Even though it is an over the counter supplement, it is not recommended by any reputable manufacturer to be taken before you are 18. If you are asking about it as a way to increase your testosterone levels, remember if it was successful it would prematurely lead to your bones fusing and stunt your growth/height! ...Read more

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How are lipase inhibitors (orlistat) used as a fat blocking medication?

How are lipase inhibitors (orlistat) used as a fat blocking medication?

Orlistat stool chang: No every body who takes orlistat has fatty stools, that how it works by blocking the absorption of fats
orlistat blocks the absorprtion of fats and fats are in the stools undigested and there is limited absorption. ...Read more

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Has anyone used lipase inhibitors (orlistat) the fat blocking medication?

Yes: When it first came out. My patients did and they did not want it anymore. ...Read more

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Hello What is the best medicine (proton inhibitor) to take for GERD. Thanks?

Hello What is the best medicine (proton inhibitor) to take for GERD. Thanks?

Nexium (esomeprazole) is: Probably the strongest second generation PPI and I would recommend it. It is OTC but prescription may be cheaper. ...Read more

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Can aromatase inhibitors be used to increase final height in puberty in boys?

Can aromatase inhibitors be used to increase final height in puberty in boys?

May be effective: For boys with short stature, and no other known cause, aromatase inhibitors have been used. It is still considered experimental, and it is not clear that it will increase adult height. Much depends on the specific condition. As with anything that may increase testosterone, there are side effects. You should only do this under the care/supervision of a pediatric endocrinologist. ...Read more

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Anyone know what is a PCR inhibitor and what leads to that in a persons blood?

Anyone know what is a PCR inhibitor and what leads to that in a persons blood?

Unclear question: By pcr most people mean "polymerase chain reaction" and pcr inhibitor in blood is not a known disorder. ...Read more

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What is the definition or description of: selective serotonin reuptake inhibitor?

What is the definition or description of: selective serotonin reuptake inhibitor?

SSRI's: Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders. ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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What is an inhibitor for the cyp2c8 (mainly involved in actos (pioglitazone) metabolism)?

What is an inhibitor for the cyp2c8 (mainly involved in actos (pioglitazone) metabolism)?

Liver enzyme: The cyp2c8 enzyme contributes to the metabolism of many drugs. This enzyme consists of less than 10% of the total cytochrome components in the liver, though has also been found in other organs. Even if inhibited, other pathways are available to metabolize drugs which helps the body avoid toxic build- up of drug metabolites. ...Read more

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Hbp #: how long would it typically take for an extended release ACE inhibitor to have it's full effect?

Hbp #: how long would it typically take for an extended release ACE inhibitor to have it's full effect?

Days: Most long-acting ace-i (and many other cardiac meds) produce a measurable response within a couple days but may take up to 2-3 weeks for the full effect. ...Read more

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I read that paxil is NOS inhibitor. What that means? What are the advantages and disadvantages of this effect?

I read that paxil is NOS inhibitor. What that means? What are the advantages and disadvantages of this effect?

Too technical but...: 2010 paper says “preclinical studies have demonstrated that inhibition of NOS produces anxiolytic and antidepressant-like behavioral effects in a variety of ANIMAL...The studies are primarily acute studies, and there is a great need for examination of the chronic effects...There are several HUMAN studies indicating an important role of elevated NO in the pathogenesis of affective disorders and..." ...Read more

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If its not possible for aromatose inhibitors to affect discs (ddd) how come cigarettes do? (i do not smoke) but am curious as to how!

If its not possible for aromatose inhibitors to affect discs (ddd) how come cigarettes do? (i do not smoke) but am curious as to how!

Nicotine: Theveffecy of nicotine on disc is multifactorial and unknown nicotimecis a potent vasoconstrictor which inhibits healing the disc spacecrzpecially nucleus pulposis has a poor native blood supply less blood ischemia accelerted degentation or mited healing response to daily injuries acclerates degeneration it happens with smoklrss tabacco as well no nicotine no effect in disc. ...Read more

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Prostate is enlarged again with inhomogenous echotexture even while taking 5-alpha-reductase inhibitors medicines. Is this very dangerous sign?

Prostate is enlarged again with inhomogenous echotexture even while taking 5-alpha-reductase inhibitors medicines. Is this very dangerous sign?

See remark: Are you talking about your husband? Young lady? The medicine taken is to SHRINK the size of prostate
If there is irregularity in texture of prostate, consult with a urologist. He must not be old if you're 28 yrs.
The medicine taken MAY cause changes in prostate
Relax, Tumor is not common in middle age men specially from your part of the world. Best regards ...Read more

Dr. Brad Goldenberg
24 Doctors shared insights

Calcineurin Inhibitor (Definition)

Topical calcineurin inhibitors are second line treatments for eczema, when ...Read more


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