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Doctor insights on: Tolerance To Alprazolam

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Need some recommendations for calming panic since I have built up a tolerance to xanax (alprazolam)?

Need some recommendations for calming panic since I have built up a tolerance to xanax (alprazolam)?

Antidepressants: First and foremost, ssri and snri drugs are really the best drugs to prevent panic attacks, and work reasonably well for this. Benzodiazepines were never meant to be taken chronically for what is an intermittent acute problem like panic attacks. However, if tolerance is present. Alprazolam or Lorazepam (or any benzo really) will still work - just needs a higher dose. Psychotherapy also can work. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more


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Hi docs, would temazepam help me sleep if i already have a high tolerance to xanax (alprazolam)?

Hi docs, would temazepam help me sleep if i already have a high tolerance to xanax (alprazolam)?

Probably not: At least not in the usual doses. The high tolerance and use of xanax, (alprazolam) a notoriously short-acting drug where when it wears off, worse insomnia occurs, may be the cause of your sleep problems. Adding more drugs to problems being caused by drugs is a sure way to enter a vicious cycle of escalating doses, escalating dependency, increasing side effects and problems with addiction and its complications. ...Read more

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I took 1.5mg Xanax (alprazolam) for two weeks to sleep and it worked very well until developing a tolerance. Is there a suitable long-term replacement?

I took 1.5mg Xanax (alprazolam) for two weeks to sleep and it worked very well until developing a tolerance. Is there a suitable long-term replacement?

Have you tried : Melatonin ; good sleep hygiene. Retire ; rise same time each day. Keep bedroom dark ; cool ; use only for sex ; sleep. Turn off tv. No naps. Exercise regularly but not in late evening. No caffeine for 6 hrs ; no alcohol or tobacco w/i 2 hrs of sleep. Keep dinner moderate sized ; finish at least 2 to 3 hrs before sleep. Can try warm milk, chamomile tea or melatonin along w light reading ; warm bath. ...Read more

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How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?

How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?

Just not everyday: If you skip days fairly often, e.g., 2 or 3 times a week, you are unlikely to develop a tolerance over time. Any skipped day gives your body a chance to "reset". If you take it too many days in a row and then skip a day, you'll have withdrawal or rebound anxiety on the skipped day, and you'll know in the future to skip days more often. Psychological dependence is a different matter of course. ...Read more

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How long can one be on benzodiazepines hypothetically when starting on a low dose (e.G Xanax (alprazolam) 0.25 mg) until tolerance induction?

How long can one be on benzodiazepines hypothetically when starting on a low dose (e.G Xanax (alprazolam) 0.25 mg) until tolerance induction?

No time limit: Tolerance can develop quickly with medications like xanax (alprazolam) and is the main reason fot them to get abused. It is advisable to be under a physician's care to ensure the medication is treating the symptoms for which it is prescribed. ...Read more

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I take Xanax (alprazolam) 0.25 like six times a day because I created tolerance and I am in the process of detox, will this cause GERD from taking so many pills?

Detox & reflux?: Number if tablets has no effect on reflux. However, if you are being tapered down on your Xanax (alprazolam), (alprazolam) you may experience anxiety. Anxiety frequently causes exacerbations of reflux. Anxiety can also cause burning sensations, nausea & gi discomfort that is not necessarily GERD. Xanax (alprazolam) should be tapered only with the supervision of a doctor. Let ur doc know symptoms u've been having 2 get proper treatment ...Read more

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Med stronger than Xanax (alprazolam) for panic? High tolerance, 8mg doesn't phase me. Strongest med for mdd? Been thru all, ssri & maoi. Ect failed, 33 treatments.

TRD: You may want to get evaluated for tms or vns after ruling out other medical or drug induced condition sorry to hear you are in such suffering. ...Read more

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My tolerance is out the roof for xanax (alprazolam) and similar Rx is there something stronger that my doc likely give me to control anxiety no buspar/ vistaril?

My tolerance is out the roof for xanax (alprazolam) and similar Rx is there something stronger that my doc likely give me to control anxiety no buspar/ vistaril?

Not drugs alone: Consider psychotherapy in addition to your meds. Drugs alone are often not sufficient to control generalized anxiety. Cognitive behavioral therapy can work well with your meds to get your anxiety under control. If none of the drugs you have tried are helping you, you may need to taper off them with your doctor's assistance. All drugs have side effects. ...Read more

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Would taking Xanax about 2 times per week, keep someone from developing a tolerance?

Would taking Xanax about 2 times per week, keep someone from developing a tolerance?

Probably: Sticking to 1-2mg total dose per week is unlikely to provoke tolerance or physicial dependence. Those with a history of substance abuse of any substance should avoid Xanax because of the possibility of loss of control and addiction. ...Read more

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Would I develop dependence or tolerance to Xanax taking 0.5mg 3-4 times a week for over a year?

Yes mame: Stay away from these dependency drugs Tell your doctor to treat you with safer and yet effective medication ...Read more

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My son took 5 Xanax bars (10mg) and several Neurontin( Approx. 2000 -3000mg). hes 27 w/high tolerance to both drugs. Can he overdose on this?

Overdosage : Needs to g to ER, this is clearly an over dose, especially the xanax, which moreover would interact inadvertently with the neurontin causing CNS depression, even if he is tolerant to either drug, good luck ...Read more

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Is requip in the same family of drugs as xanax (alprazolam)? Is it addicting, and do you have to wean off it? Can you also build up a tollerance to it ?

Is requip in the same family of drugs as xanax (alprazolam)? Is it addicting, 
and do you have to wean off it? Can you also build up a
tollerance to it ?

DIFFERENT: Completely different classes of medications as Requip effects Dopamine for restless leg or parkinson and xanax (alprazolam) is a benzodiazepine and is for anxiety. Requip is non addictive may build up tolerance after a long time. Should always taper off medications slowly if the dosage is high. It is safer that way. ...Read more

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What is alprazolam?

What is alprazolam?

Xanax (alprazolam): Is an anxiolytic medication of intermediate half-life, used for panic disorder. Side effects include sedation, dry mouth, nausea, headaches, lack of focusing, change in taste & smell senses, most of such effects are uncommon & dose-related. ...Read more

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How much alprazolam is safe?

How much alprazolam is safe?

Xanax (alprazolam): Depending on age and tolerance and severity of symptoms and if taken alone or with other medications. Generally, i would not recommend daily dose above 4-6 mg. ...Read more

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How safe is xanax (alprazolam)?

Safely addictive: Xanax (alprazolam) is safe if one does not use heavy machinery or drive while on it. It doesnt interact with too many meds. However, if used chronically, it can worsen or cause very discomforting anxiety, tolerance and withdrawal when stopped. ...Read more

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Dr. Alan Ali Dr. Ali
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What is Xanax (alprazolam) for?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What is Xanax (alprazolam) for?

Xanax (alprazolam): An intermediate-acting benzodiazepine, it is used more often for panic disorder. ...Read more

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How do I quit taking alprazolam?

Get Help: Talk to your doctor about mental health professional near you. You should cut back slowly if you have been taking it for a long time. You need to talk to your doctor about other medications, other strategies. You may need a treatment program to help you. Benzos are addictive. ...Read more

Dr. Alan Ali
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Alprazolam (Definition)

Alprazolam is a short acting benzodiazepine, it does not last long in the system . So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight , dentist or other infrequent anxieties, ...Read more


Xanax (Definition)

Alprazolam is a short-acting benzodiazepine which is a kind of sleep-inducing drug ...Read more