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Doctor insights on: Tolerance To Alprazolam

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Need some recommendations for calming panic since I have built up a tolerance to xanax (alprazolam)?

Need some recommendations for calming panic since I have built up a tolerance to xanax (alprazolam)?

Antidepressants: First and foremost, ssri and snri drugs are really the best drugs to prevent panic attacks, and work reasonably well for this. Benzodiazepines were never meant to be taken chronically for what is an intermittent acute problem like panic attacks. However, if tolerance is present. Alprazolam or Lorazepam (or any benzo really) will still work - just needs a higher dose. Psychotherapy also can work. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more


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Hi docs, would temazepam help me sleep if i already have a high tolerance to xanax (alprazolam)?

Hi docs, would temazepam help me sleep if i already have a high tolerance to xanax (alprazolam)?

Probably not: At least not in the usual doses. The high tolerance and use of xanax, (alprazolam) a notoriously short-acting drug where when it wears off, worse insomnia occurs, may be the cause of your sleep problems. Adding more drugs to problems being caused by drugs is a sure way to enter a vicious cycle of escalating doses, escalating dependency, increasing side effects and problems with addiction and its complications. ...Read more

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I took 1.5mg Xanax (alprazolam) for two weeks to sleep and it worked very well until developing a tolerance. Is there a suitable long-term replacement?

I took 1.5mg Xanax (alprazolam) for two weeks to sleep and it worked very well until developing a tolerance. Is there a suitable long-term replacement?

Have you tried : Melatonin ; good sleep hygiene. Retire ; rise same time each day. Keep bedroom dark ; cool ; use only for sex ; sleep. Turn off tv. No naps. Exercise regularly but not in late evening. No caffeine for 6 hrs ; no alcohol or tobacco w/i 2 hrs of sleep. Keep dinner moderate sized ; finish at least 2 to 3 hrs before sleep. Can try warm milk, chamomile tea or melatonin along w light reading ; warm bath. ...Read more

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How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?

How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?

Just not everyday: If you skip days fairly often, e.g., 2 or 3 times a week, you are unlikely to develop a tolerance over time. Any skipped day gives your body a chance to "reset". If you take it too many days in a row and then skip a day, you'll have withdrawal or rebound anxiety on the skipped day, and you'll know in the future to skip days more often. Psychological dependence is a different matter of course. ...Read more

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I take Xanax (alprazolam) 0.25 like six times a day because I created tolerance and I am in the process of detox, will this cause GERD from taking so many pills?

Detox & reflux?: Number if tablets has no effect on reflux. However, if you are being tapered down on your Xanax (alprazolam), (alprazolam) you may experience anxiety. Anxiety frequently causes exacerbations of reflux. Anxiety can also cause burning sensations, nausea & gi discomfort that is not necessarily GERD. Xanax (alprazolam) should be tapered only with the supervision of a doctor. Let ur doc know symptoms u've been having 2 get proper treatment ...Read more

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How long can one be on benzodiazepines hypothetically when starting on a low dose (e.G Xanax (alprazolam) 0.25 mg) until tolerance induction?

How long can one be on benzodiazepines hypothetically when starting on a low dose (e.G Xanax (alprazolam) 0.25 mg) until tolerance induction?

No time limit: Tolerance can develop quickly with medications like xanax (alprazolam) and is the main reason fot them to get abused. It is advisable to be under a physician's care to ensure the medication is treating the symptoms for which it is prescribed. ...Read more

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Med stronger than Xanax (alprazolam) for panic? High tolerance, 8mg doesn't phase me. Strongest med for mdd? Been thru all, ssri & maoi. Ect failed, 33 treatments.

TRD: You may want to get evaluated for tms or vns after ruling out other medical or drug induced condition sorry to hear you are in such suffering. ...Read more

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Dr. Alan Ali
903 doctors shared insights

Alprazolam (Definition)

Alprazolam is a short acting benzodiazepine, it does not last long in the system . So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight , dentist or other infrequent anxieties, ...Read more


Xanax (Definition)

Alprazolam is a short-acting benzodiazepine which is a kind of sleep-inducing drug ...Read more