Doctor insights on:
Tissue Plasminogen Activator
The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more
What are the differences between recombinant tissue plasminogen activator and tissue plasminogen activator?
Same aa sequence: TPA and its recombinant version (Activase) are identical with respect to the amino acid sequence. There have been reported some minor differences with respect to glycosylation of the protein, but this is well within the specifications of the cGMP production by the manufacturer. ...Read more
Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! Time is brain! ...Read more
Got superficial blood clots in left arm with no cause again. Coagulation panel showed high plasminogen. What does that mean?
Too much plasminogen: Your high plasminogen likely causes, or is related to, your clotting problem. See an explanation of your rare disorder on this website (cut and paste into web browser): http://www. Chla. Org/site/c.ipINKTOAJsG/b.7717791/k.A1D0/Disorders_of_Fibrinolysis__Bleeding_Disorder__Plasminogen. Htm#.VAhd29m9LCQ Talk to a hematologist for more understanding. Best wishes! ...Read more
What do you think of optimal chiropractic treatment with the activator appliance for soft tissue injury following an rta 5 yrs ago?
Not much: Chiropractic "treatment" is a form of exaggerated massage designed to keep you coming back for steady income. There is little in chiropractic practice or theory which can be considered to have as a goal - cure. If you have a persistent problem you should see your orthopedic physician for a true understanding. ...Read more
My mother is suffering from acute ischemic stroke, she is diabetic, her late arrival to the hospital made situation bad since none of the initial tissue activator were given to her. How can I manage her health situation?
You can't on ur own: First, I am sorry for what happened to your mother, and wish her recovery and health. Second, this a complex health situation, a team approach of physicians, nurses, physical therapist, rehab specialists, helpers, social workers would all act together, your part would be to coordinate her care being a loving and caring son, hope all or part of those facilities are available for your mother, ...Read more
Alteplase: Yes you do.Get a more detailed answer ›
Apples vs. Oranges: They are both cardiac medicines. They are however used for totally different reasons. Calcium blockers are most commonly used to treat high blood pressure. They may also be used to treat chest pain or to slow the heart. Clot busters are used to dissolve a clot in the arteries that supply blood to the heart itself and therefore to limit the amount of heart damaged by removing the blockage. ...Read more
Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?
Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more
FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo. Gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www. Drugs. Com/cdi/alteplase. Html & http://www. Activase. Com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more
Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more
Used to be rigid: Used to be arbitrary age which I believe was 75 and now is individualized. ...Read more
TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more
2 years ago all tests say I didn't have a stroke. Administered tpa (alteplase) and improved. Why did I respond to a drug for something tests say I didn't have?
Question: So if you didn't have a stroke what improved when you got the TPA (alteplase)? ...Read more
No: NoGet a more detailed answer ›
They can: If having a stroke one can receive intravenous tpa (alteplase) up to 3 hours once symptoms begin and up to 4.5 hours in certain cases. After this intra. ...Read more
Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more
Might help: When thromboplastin activator first appeared it was felt dangerous for elderly pts, and only safe if used very early. All of this is now modified and it may be both safe and effective in older pts if additional risk factors are not present. However, still most effective if used as early as possible. ...Read more
Opinion: You may find a variable amount of opinions but from a neurosurgeons perspective, the risk is too high to give tpa (alteplase) to a 95 year old with a stroke. Someone needs to have a frank discussion with the family regarding proper treatment for patients of a certain age. The tpa (alteplase) may work great, but the risks of hemorrhage or other life threatening complications is high. ...Read more
CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism
recent stroke. See: ...Read more
This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase).
It also depends on how long the symptoms have been occurring.
But to answer your question, theoretically all could potentially benefit. ...Read more