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Doctor insights on: Thyroidectomy And Tpo Antibodies

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Suffered from thyroiditis for years and recently had thyroidectomy. What do antibodies attack if gland is removed?

Suffered from thyroiditis for years and  recently had thyroidectomy. What do antibodies attack if gland is removed?

Probably nothing: This is a good question. In most cases, hashimoto's thyroiditis is limited to the thyroid. Thyroid gone (or hypothyroidism) and there is no more inflammation. Presumably those antibodies don't attack anything. But people with hashi can get other autoimmune diseases, such as addison's, type 1 diabetes, pernicious anemia, and others. But this is not common. ...Read more

Dr. M. Hytham Beck
46 doctors shared insights

Thyroid Peroxidase Antibodies (Definition)

The body uses antibodies to attack and remove foreign substances. Useful as an aid in the diagnosis of thyroid autoimmune disorders; differentiating thyroid autoimmune disorders from nonautoimmune goiter or hypothyroidism; as a diagnostic tool in deciding whether to treat a patient ...Read more


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Is it possible recurrence of thyroid cancer if thyroglobulin came back positive but antibodies are decreasing? Had full thyroidectomy 2 years ago.

Is it possible recurrence of thyroid cancer if thyroglobulin came back positive but antibodies are decreasing? Had full thyroidectomy 2 years ago.

Recurrence: Rest assured. It is impossible to say you are cancer free, but that is likely. Here's why: the thyroglobulin level is unreliable because you have antibodies. The fact that the antibodies are decreasing can mean that thyroglobulin is decreasing. Antibodies can be a tumor marker surrogate. Continue to follow the antibody trend and get periodic neck ultrasounds. ...Read more

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6 montes after thyroidectomy and rai, thyroglobuline <0.1 ng/ml and antithyroglobuline antibodies are 47.8 iu/ml. No TSH elevation. Is this good, bad?

6 montes after thyroidectomy and rai, thyroglobuline <0.1 ng/ml and antithyroglobuline antibodies are 47.8 iu/ml. No TSH elevation. Is this good, bad?

Okay: I assume that you had thyroid cancer. If this is the case, you want to be on enough thyroid hormone so that the TSH is in the lower range of normal or slightly low (0.2-1.0). Unfortunately, having thyroglobulin antibodies makes the thyroglobulin level unreliable as an indicator or residual thyroid tissue. ...Read more

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I had a total thyroidectomy with pathology of hyalinizing trabecular tumor. But I have thyroglobulin antibodies how come? Also can't get TSH down

I had a total thyroidectomy with pathology of hyalinizing trabecular tumor. But I have thyroglobulin antibodies how come? Also can't get TSH down

Hypothyroidism: The thyroid condition you have is rare and is considered by many a variant of papillary carcinoma which commonly arises in chronic thyroiditis as indicated by your elevated thyroglobulin antibodies. The destruction of normal thyroid cells from chronic inflammation or complete surgical removal leads to hypothyroidism reflected by elevated tsh. See your endocrinologist for treatment. ...Read more

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Positive for thyroid paroxidase antibodies and thyroglobulin antibodies. What does this mean? Had pap thyroid cancer in 2008 with thyroidectomy

Immunity to thyroid: The thyroid makes thyroglobulin (tg) and thyroid peroxidase (tpo). Even though you had your thyroid removed, your body's immune system sees tg and tpo as foreign and has made antibodies to them. This means that following your tg as a way to monitor your thyroid cancer might be unreliable. It could also mean you have thyroid tissue that is still present in your body. Ask your endocrinologist! ...Read more

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Anti tpo antibodies 1300. What does this mean?

Hashimotos: This would suggest autoimmune thyroid disease, either hashimotos thyroiditis or graves disease. But it is not diagnostic. See your endocrinologist. ...Read more

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What happens if I have a mild giter and tpo antibodies and antithyroglobulin antibodies is that normal?

What happens if I have a mild giter and tpo antibodies and antithyroglobulin antibodies is that normal?

Hashimoto's : Hi. Sounds like Hashimoto's to me! Is your thyroid function normal? Or not? Did your doc recommend treatment? ...Read more

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How can you be negative for anti-TPO antibodies if they are detected, even if they are in the normal range? Does anyone have a value of 0 for these?

How can you be negative for anti-TPO antibodies if they are detected, even if they are in the normal range? Does anyone have a value of 0 for these?

Lab practice: This is an arcane subject in clinical pathology. Antibodies are detected based on activities, not the specific identification of molecules. A lab sets a decision level at which an assay is reported as likely to indicate disease, with the understanding that what is really being measured is the ability of all the proteins totaled to bind to the test antigen. ...Read more

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What are thyroid peroxidase antibodies?

What are thyroid peroxidase antibodies?

Thyroid antibody: They are made by your own wbcs directed against peroxidase, an enzyme on the thyroid microsome. People with hashimoto's and graves' diseases may have + antibodies to the thyroid peroxidase. ...Read more

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My blood endocrinology test report says thyroglobulin antibody more than 1000.00IU/ml and anti TPO antibodies 116.52IU/ml what does it mean plz help?

My blood endocrinology  test report says thyroglobulin antibody more than 1000.00IU/ml and anti TPO antibodies 116.52IU/ml what does it mean plz help?

Thyroid Autoimmune d: It means your Thyroid gland damge caused by the immune system.It may be due to 1Graves Dusease 2Hashimotos Disease or Thyroditis 3Hypothyroidism 4Thyrotoxicosis You must have had other tests likeTSH,T3,T4,FREET4 You should discuss with your endocrinologist what condition you have and thr recommended treatment ...Read more

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What can cause raised MCV(102) and MCH(2.16)? I have TPO antibodies but other thyroid levels are fine. B12 is 273. Something to worry about?

What can cause raised MCV(102) and MCH(2.16)? I have TPO antibodies but other thyroid levels are fine. B12 is 273. Something to worry about?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your B12 level is at the lower end of normal. Please discuss with your doctor if you may benefit from B12 supplement, may be by injection. Your doctor may wish to check you folate (folic acid) level, especially if Hgb is low. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine. ...Read more

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What is the meaning of high level of anti-TPO antibodies but normal TSH and t4?

What is the meaning of high level of anti-TPO antibodies but normal TSH and t4?

Hashimoto's thyroid : It means you have hashimoto's thyroid disease but your thyroid function is currently normal. This might be because you are taking the correct dose of thyroid hormone replacement or because your thyroid is still able to make normal amount of hormone despite the insults from the antibodies. If this is the case, monitor your thyroid function closely because you will become hypothyroid in the future. ...Read more

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What does it mean if my TSH is higher than normal and so are my TPO antibodies but my T4 levels are normal? I was told i have hashimoto's.

What does it mean if my TSH is higher than normal and so are my TPO antibodies but my T4 levels are normal? I was told i have hashimoto's.

Consistent with: Hashimoto. Please do follow up with your doctor as you are heading toward thyroid deficiency and if your doctor suggests going on thyroid replacement, it would be good to comply with the doctor's advice. ...Read more

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Low free t3, (liothyronine) normal TSH and high tpo antibodies. What's this mean?

Low free t3, (liothyronine) normal TSH and high tpo antibodies. What's this mean?

Probable hypothyroid: The free t4, not free T3 (liothyronine) test, is necessary here. Positive antibodies indicate hashimoto's thyroiditis, the most common cause of hypothyroidism. It may just be early in the process to cause the TSH to be elevated. ...Read more

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My TSH level is 2.61 with 25mcg synthroid, (thyroxine) but my TPO antibodies are 17.I want to conceive now, how risky is it?Can Synthroid (thyroxine) lower my TPO antibodies?

Not likely: Synthyroid replaces the hormone not being produced by the thyroid, but does not alter the disease in thyroid. TPO antibodies should not interfere with your pregnancy. ...Read more

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24 yr male with 60 kg, 5.5" tall, high anti-TPO antibodies..And a slightly elevated tsh.. Normal t3and t4..Not gaining weight.. Shd i start thyroxine?

24 yr male with 60 kg, 5.5" tall, high anti-TPO antibodies..And a slightly elevated tsh.. Normal t3and t4..Not gaining weight.. Shd i start thyroxine?

Hard call: Different endocrinologists will offer you different opinions. Staying trim like you are now is of course good. The question is whether your hashimoto's (which i suspect you have -- does your physician?) is slipping into hypothyroidism; only a minority do -- and if so, whether you want to take a bit of thyroxine perhaps as an experiment. Talk with yourdoctor & perhaps a 2nd opinion. Good luck. ...Read more

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My TSH levels after 25mcg Synthroid (thyroxine) treatment are lowered from 4.67 to 2.61 in 18 days.TPO antibodies are 17. Is it safe to conceive now?

Hypothyroidism/preg: Usually with untreated hypothyroidism, it will be difficult to conceive. With high TPO antibodies, there is a higher risk of spontaneous abortion and preterm births. Knowing that, it is fine to try conceive now. As per 2013, treatment of TPO antibodies with IVIG or selenium is not recommended. http://www.hindawi.com/journals/jtr/2013/542692/tab2/ ...Read more

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Do I need thyroid hormone if I have low free t3, (liothyronine) normal TSH and high tpo antibodies?

Do I need thyroid hormone if I have low free t3, (liothyronine) normal TSH and high tpo antibodies?

Possibly.: The TSH is normal so it might be a variation of normal or euthyroid. It also might be a developing thyroid condition, but there would be symptoms, like fatigue. The tpo antibodies might mean hashimoto's thyroiditis. This is usually associated with hypothyroidism. It would be wise to see your doctor to follow up. ...Read more

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21 yr old, been v sick with suspected dysautonomia since flu in feb. Endocrinologist today felt goitre and ordered tpo antibodies test. Hashimotos or other autoimmune disorder poss with normal tsh?

21 yr old, been v sick with suspected dysautonomia since flu in feb. Endocrinologist today felt goitre and ordered tpo antibodies test. Hashimotos or other autoimmune disorder poss with normal tsh?

Yes: The autoimmune process may not have advanced sufficiently to impact the pituitary regulation of the thyroid (TSH) but autoantibodies may be detectable in a blood test. The clinical significance of these lab results is a matter of interpretation and judgment by your doctor. ...Read more

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Hypothyroidism w/ elevated tpo antibodies, low t, adrenal insufficiency... Synthroid (thyroxine) & testosterone hasn't helped. Can I have an autoimmune disease?

You do have it: Elevated tpo antibodies confirms you have autoimmune thyroiditis. This is often triggered by environmental toxins ;/or infections. You will likely benefit from adding liothyronine to your regimen ; treating adrenal problems with cordyceps, rhodiola etc. I advise consulting with a holistic doc. See http://abt.Cm/18gpb3a ; http://bit.Ly/15k26u8 ; http://bit.Ly/17nx2ax ; http://bit.Ly/16blg0r. ...Read more

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What does it mean to have high tpo antibodies but Normal tsh t4 t3 (liothyronine) function? Enlarged thyroid-US heterogenous thyroid parenchyma with hypervascularity

Thyroiditis: You likely have thyroiditis (autoimmune)in its early stage and you need to consult your doctor for Rx and monitor. ...Read more

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Thyroid swelling. Ultrasound heterogenous thyroid parynchema with hypervascularity. Blood test-normal tsh t4 t3 (liothyronine) etc but >1300 TPo antibodies?

Thyroid swelling. Ultrasound heterogenous thyroid parynchema with hypervascularity. Blood test-normal tsh t4 t3 (liothyronine) etc but >1300 TPo antibodies?

Hard to say: Ive yet to have anyone NOT have elevated TPo but I havent sent many. The standard answer would be that it likley is GRAVES disease starting but if there arent a lot of symptoms and the labs are normal you wouldnt give treatment. Retesting if symptoms and at about every 3 months. ...Read more

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Thyroid Ultrasound heterogenous thyroid parynchema with hypervascularity. Blood test normal tsh t4 t3 (liothyronine) etc but >1300 TPo antibodies?have Hypo symptoms

Elevated: TPO levels are associated with autoimmune thryroid disease/thryoiditis, for example Hashimoto disease. The thyroid US findings are also consistent with thyroiditis. Talk to your doc about next steps. ...Read more

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Can tpo antibodies be present in subacute thyroiditis? Or does it mean I have hashimotos. Swollen thyroid Tsh normal. Cold hands fatigue hair falling

Anti TPO antibodies: Can be elevated in some people with normal thyroids, and are markers of thyroiditis, depending on the levels and the follow up. Your symptoms don't point to a specific disease and can be common to other problems as well, your best bet is to see your doctor/endocrinologist for assessment and further management, best wishes ...Read more

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Stopped birth control pill March 25. Hot flashes, mood swings, when will my period start or ovulation? Have high TPo antibodies normal tsh t4 t3 (liothyronine)

Stopped birth control pill March 25. Hot flashes, mood swings, when will my period start or ovulation? Have high TPo antibodies normal tsh t4 t3 (liothyronine)

Thyroid testing: The most important issue is to have your primary care doctor or endocrinologist evaluate your elevated thyroid peroxidase enzymes to determine the cause and treatment. Birth control pills are out of your system in about 7 days returning you to your normal state. One would expect a menstrual cycle about 1 month after stopping them unless pregnancy occurred ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dr. William Culviner
367 doctors shared insights

Thyroidectomy (Definition)

is the surgical removal ...Read more