thyroid peroxidase antibodies

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Description
Conditions (11)
The body uses antibodies to attack and remove foreign substances. Useful as an aid in the diagnosis of thyroid autoimmune disorders; Differentiating thyroid autoimmune disorders from nonautoimmune goiter or hypothyroidism; As a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism.

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Dr. David Geffner answered:

What are thyroid peroxidase antibodies?

Thyroid antibody

Thyroid
They are made by your own WBCs directed against peroxidase, an enzyme on the thyroid microsome. People with Hashimoto's and Graves' diseases may have + antibodies to the thyroid peroxidase.
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Dr. David Sneid answered:

What are the normal thyroid peroxidase antibodies?

Usually very low

Thyroiditis
TPO antibodies are generally low or absent unless you have had Hashimoto's thyroiditis. Once they occur, they may decline slowly or last a lifetime.
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Dr. David Sneid answered:

Thyroid peroxidase antibody level is 200. What does that mean?

Prior thyroiditis

Thyroid_gland
It means you have had prior thyroiditis at some time in the past. Repeated episodes of thyroiditis can possibly lead to an underactive thyroid in the future.
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What is the definition or description of: Thyroid peroxidase antibodies?

Thyroperoxidase(TPO)

Thyroid
The body uses antibodies to attack and remove foreign substances. Useful as an aid in the diagnosis of thyroid autoimmune disorders; Differentiating thyroid autoimmune disorders from nonautoimmune goiter or hypothyroidism; As a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism.
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Dr. David Geffner answered:

Any reason for a high level for thyroid peroxidase antibody other than hypothyroidism?

Yes and no

Antibody
A positive TPO antibody merely means that you may have Hashimoto's disease. The Wickham and Framingham studies show that people with + abs will eventually get hypothyroid. + abs are also seen in patients with hyperthyroidism due to Graves" disease.
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Dr. Dan E. Fisher answered:

Regarding thyroid peroxidase antibodies, if I am positive, should my kids all be checked?

No.

Hypothyroidism
Anti TPO Ab are not inherited directly. If your child develops signs and symptoms of hypothyroidism it might be reasonable to check a TSH, but not TPO.
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Negative result for thyroid peroxidase antibodies TPOAb . Necessary to test my thyroglobulin antibodies TgAb ?

Anti-thyroglobulin

Thyroid_gland
Studies have shown that 99% of patients with hashimoto's thyroiditis have anti-microsomal antibodies, whereas only about 1/3rd had anti-thyroglobulin antibodies. In addition, 10-20% of persons without thyroid problems have anti-throglobulin antibodies (TG-A). These persons are likely at higher risk for future problems and should be watched more closely however, testing for TG-A is not necessary
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Dr. John T. Chiu answered:

TSH now 9.25, (was 31.9 in Feb2013 when discovered). Thyroid peroxidase antibody lev 16. Does this mean Hasimoto's is the cause of my Hypothyroidism?

Improving

Toxic_thyroid_adenoma
The lower TSH means that your thyroid function is under better control. It also appears likely that the problem is related to Hashimoto's .
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Dr. John T. Chiu answered:

TSH -6.65/ T3-4.5/T4-18.7 on 23rd jan 14 and TSH -0.02 and T3-5.6/ T4-23 on 13th dec13and got flu shot on 4 th jan 14 Thyroid peroxidase antibody- 365?

See endocrinologist

Thyroid
Assuming that you have rec'd no treatment, the extreme changes in thyroid (& TSH) function plus the high anti-TPO suggest that you are having active thyroiditis and need to see an endocrinologist.
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Dr. Hassan Arshad answered:

23 yrs old F; thyroid peroxidase 13 (norm); Thyroglobulin, Antibody 3.0 (High); TSH 10.850 (High); Nomal T3 & T4. Hashimotos? Possible Thyroid cancer

Possible to 1st

Cancer
Thyroglobulin is a test that is helpful after someone has surgery for the most common thyroid cancer. Thyroid function tests can test how well your thyroid is working. If there is concern for cancer it is helpful to get a thyroid ultrasound and then a biopsy if clinically indicated.
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