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Doctor insights on: Thyroglobulin Antibodies Thyroid Cancer

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Positive for thyroid paroxidase antibodies and thyroglobulin antibodies. What does this mean? Had pap thyroid cancer in 2008 with thyroidectomy

Positive for thyroid paroxidase antibodies and thyroglobulin antibodies. What does this mean? Had pap thyroid cancer in 2008 with thyroidectomy

Immunity to thyroid: The thyroid makes thyroglobulin (tg) and thyroid peroxidase (tpo). Even though you had your thyroid removed, your body's immune system sees tg and tpo as foreign and has made antibodies to them. This means that following your tg as a way to monitor your thyroid cancer might be unreliable. It could also mean you have thyroid tissue that is still present in your body. Ask your endocrinologist! ...Read more

Dr. Barry Rosen
4,298 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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I have hashimotos and i just got my bloodwork .Thyroglobulin is way high and I have no antibodies. Is this a sign i might have thyroid cancer?

I have hashimotos and i just got my bloodwork .Thyroglobulin is way high and I have no antibodies. Is this a sign i might have thyroid cancer?

See your doc: Thyroglobulin is only made by thyroid cells. All an elevated thyroglobulin tells you is that you have "something" going on with your thyroid. It could just be inflammation, but you can't know until more tests are done. This test is not a sensitive or specific test for diagnosing thyroid cancer. See an endocrinologist to find out more. ...Read more

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Is it possible recurrence of thyroid cancer if thyroglobulin came back positive but antibodies are decreasing? Had full thyroidectomy 2 years ago.

Is it possible recurrence of thyroid cancer if thyroglobulin came back positive but antibodies are decreasing? Had full thyroidectomy 2 years ago.

Recurrence: Rest assured. It is impossible to say you are cancer free, but that is likely. Here's why: the thyroglobulin level is unreliable because you have antibodies. The fact that the antibodies are decreasing can mean that thyroglobulin is decreasing. Antibodies can be a tumor marker surrogate. Continue to follow the antibody trend and get periodic neck ultrasounds. ...Read more

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I had a thyroglobulin antibody test taken and the results were 320. What does this mean? Should I be concerned about lupus, hashimoto's disease or thyroid cancer? I have been diagnosed with hypothyroid and the medicine I have been taking in addition to ve

I had a thyroglobulin antibody test taken and the results were 320. What does this mean? Should I be concerned about lupus, hashimoto's disease or thyroid cancer? I have been diagnosed with hypothyroid and the medicine I have been taking in addition to ve

Hashimoto's you have: You had become hypothyroid because you have hashimoto's thyroiditis, which was confirmed by the elevated thyroglobulin activity. You should not worry about lupus, or other conditions such as cancer. The strongest association with hashimoto's and another autoimmune problem is psoriasis and psoriatic arthritis. ...Read more

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23 yrs old f; thyroid peroxidase 13 (norm); thyroglobulin, antibody 3.0 (high); TSH 10.850 (high); nomal T3 (liothyronine) & t4. Hashimotos? Possible thyroid cancer

23 yrs old f; thyroid peroxidase 13 (norm); thyroglobulin, antibody 3.0 (high); TSH 10.850 (high); nomal T3 (liothyronine) & t4. Hashimotos? Possible thyroid cancer

Possible to 1st : Thyroglobulin is a test that is helpful after someone has surgery for the most common thyroid cancer. Thyroid function tests can test how well your thyroid is working. If there is concern for cancer it is helpful to get a thyroid ultrasound and then a biopsy if clinically indicated. ...Read more

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If have thyroid cancer and my thyroglobulin continues to be high, should I see a cancer specialist?

If have thyroid cancer and my thyroglobulin continues to be high, should I see a cancer specialist?

Yes: If you have thyroid cancer, you should already have an endocrinologist and a thyroid surgeon on your team (and possibly a radiation oncologist also). They should work together to find the source of the elevated thyroglobulin. You might need radioactive iodine or repeat surgery. Good luck. ...Read more

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28 yr post thyroid cancer. Thyroglobulin level 0.2 should I be concerned?

28 yr post thyroid cancer.  Thyroglobulin level 0.2 should I be concerned?

Depends: How long ago was surgery? What kind of thyroid cancer and how big was the cancerm what is the thyroglobulin antibodies level and what is the current tsh? A tg of 0.2 is very acceptable if surgery was recently done. ...Read more

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Thyroglobulin was checked in april was .6 i and a papillary thyroid cancer patient. When should I retest the tg?

Variable: Most patients get thyroglobulin checked every 12 months. Every 6 months if there is a worry. I think a trend of increasing levels would be more worrisome. You and your doctors may discuss getting a stimulated level as well as radioactive iodine scan by making you hypothyroid or some may feel getting these tests with thyrogen stimulation could be done. ...Read more

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Can u have reccurence thyroid cancer with no thyroglubin?

Can u have reccurence thyroid cancer with no thyroglubin?

Yes: Yes but not likely. But if the path of the cancer is something other than papillary then it is more likely. Rec i131 thyrogen scan to eval for recurrent disease. ...Read more

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Does an elevated level of thyroglobulin antibodies and calcitonin mean cancer?

Does an elevated level of thyroglobulin antibodies and calcitonin mean cancer?

Elevation.: Thyroglobulin autoantibodies can be present in benign/malignant thyroid disease. If you have a diagnosis of papillary or follicular cancer, their presence can interfere with thyroglobulin as a tumor marker. If autoantibodies rise, that can be a surrogate marker for cancer recurrence. As for calcitonin, it's elevation is clinically significant in cases of primary or recurrent medullary cancer. ...Read more

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Tt papillary cancer and hurtle cell. Recent blood work TSH .59 total T3 (liothyronine) 64.7. Free T4 1.5. Thyroglobulin antibodies 1.5 what does that mean?

Thyroid cancer: Your dose of synthroid (thyroxine) should be adjusted such that your TSH is suppressed, and yours is about right, although your endocrinologist may increase your dose slightly. Thyroglobulin is a marker of recurrent cancer, but thyroglobulin antibodies can interfere with the assay. This is complicated. You need to discuss all of this with your endocrinologist. ...Read more

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Negative result for thyroid peroxidase antibodies tpoab . Necessary to test my thyroglobulin antibodies tgab ?

Negative result for thyroid peroxidase antibodies  tpoab .  Necessary to test my thyroglobulin antibodies  tgab ?

Anti-thyroglobulin: Studies have shown that 99% of patients with hashimoto's thyroiditis have anti-microsomal antibodies, whereas only about 1/3rd had anti-thyroglobulin antibodies. In addition, 10-20% of persons without thyroid problems have anti-throglobulin antibodies (tg-a). These persons are likely at higher risk for future problems and should be watched more closely however, testing for tg-a is not necessary. ...Read more

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My thyroid levels are "normal" but I have thyroglobulin antibodies present. I don't have thyroid peroxidase anti bodies though. What's going on?

My thyroid levels are "normal" but I have thyroglobulin antibodies present. I don't have thyroid peroxidase anti bodies though. What's going on?

Antibodies: Thyroglobulin antibodies sometimes have an effect on your well being and sometimes they don't. You need to discuss this with either your doctor or an endocrinologist. In the meantime don't panic. ...Read more

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My blood test showed an elevated level of tg antibodies. Does that mean I have cancerous cells running around? Had papillary thyroid cancer a year ago

Not necessarily.: Having elevated tg antibodies primarily means that the more important tg test itself will be falsely lower than its true value. (no conversion formula exists.) if your tg antibodies are only 20 or so, with an undetectable tg level, it is hard to know what that means. If your tg antibodies are much higher, then concern for the presence of thyroid cancer would increase. ...Read more

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What does it mean when thyroid peroxidase antibodies 50.2 IU/mL? Thyroglobulin antibodies 18.0 IU/mL?

What does it mean when thyroid peroxidase antibodies 50.2 IU/mL? 
Thyroglobulin antibodies 18.0 IU/mL?

Not much by itself: Thyroid antibodies are most helpful if you have a low free T4 and a high TSH indicating hypothyroidism which is most often due to autoimmune thyroid inflammation. If those tests are normal you need no treatment but your high antibodies suggest you have an increased risk of developing hypothyroidism somewhere down the road, but many people with antibodies never develop a thyroid problem. ...Read more

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Test results for throid antibodies were Anti-thyroglobulin Ab is 137 and Anti-thyroid per oxidase Ab 200 what does this mean?

High antibodies : Your antibodies against your own thyroid are high. You need to work with your doctor to figure out why. I take my patients off of gluten and encourage them to do a comprehensive elimination diet. A functional or integrative medicine doctor can work with you to find and address root causes. ...Read more

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Dr. James Lin
27 doctors shared insights

Thyroglobulin Antibodies (Definition)

Thyroglobulin antibodies are proteins made by the immune system. The immune system is recognizing the thyroid as strange to the body. Thus, this is a marker of autoimmune thyroid disease. It is usually measured to confirm hashimoto's thyroiditis, but can be seen in people without significant thyroid pathology and with normal thyroid levels. It can also be seen with ...Read more


Dr. Quang Nguyen
320 doctors shared insights

Thyroid Cancer (Definition)

Cancer that presents in the thyroid gland. It usually presents as a painless thyroid nodule. Most are papillary-follicular type and have a very good prognosis. Less common are medullary cancers, with an intermediate prognosis. Anaplastic cancers of the thyroid have a poor prognosis and are uncommon. Treatment of thyroid cancers involves removal ...Read more