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Doctor insights on: Thrombotic Thrombocytopenia Purpura In Children

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Dr. Liawaty Ho Dr. Ho
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Can you die from thrombotic thrombocytopenia purpura?

Dr. Liawaty Ho Dr. Ho
3 doctors agreed:
Can you die from thrombotic thrombocytopenia purpura?

YES: Unfortunately, yes. People can die from ttp. They can develop seizure, coma, renal failure, cardiac hemmorhage/bleeding, sudden cardiac arrest, myocardial infarction etc. Need to get treatment as soon as possible. ...Read more

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Non Blanching Red Or Purple Spots (Definition)

Non blanching red or purple spots can describe purpura, which is bleeding beneath the skin that does not blanch with pressure. It can be caused by platelet disorders, coagulation disordes, vascular ...Read more


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What is the disease ?Thrombotic thrombocytopenia purpura?

What is the disease ?Thrombotic thrombocytopenia purpura?

Abnormal platelet: Function due to deficiency of a metaloproteinase. Deficiency, usually acquired, of an enzyme that breaks down large multimers of von willebrand factor causes overactivation of platelets leading to intravascular microthrombi that affect the functions of the kidneys, brain, lungs and other organs. It can be treated by transfusing normal donor plasma. ...Read more

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Most common symptoms of thrombotic thrombocytopenia purpura?

Most common symptoms of thrombotic thrombocytopenia purpura?

Range of symptoms: Ttp can involve many different organs. One can have renal dysfunction, fever, altered mental status, low platelet counts and hemolytic anemia. These signs can lead to symptoms of bleeding, bruising, petechiae, confusion, anemia, fatigue, and possible jaundice among other things. ...Read more

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How common is it for somebody to get thrombotic thrombocytopenia purpura?

How common is it for somebody to get thrombotic thrombocytopenia purpura?

Rare disease: This is a rare but life-threatening disease; approx 2-3 cases per 100,000 population in the USA are seen. ...Read more

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What is the definition or description of: thrombotic thrombocytopenia purpura?

What is the definition or description of: thrombotic thrombocytopenia purpura?

TTP is a serious: Medical condition in which the platelets form clots within the small blood vessels throughout the body. Patients usually come to attention due to low HGB or platelets, but also may have fever, kidney insufficiency, seveer headache, and even seizures and stroke. This is an absolute medical emergency. ...Read more

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How come I have thrombotic thrombocytopenia purpura, but nobody else in the family has it?

Not hereditary: Ttp of thrombotic thrombocytopenic purpura is not a hereditary disease. Most of them is idiopathic i.e. Unknown etiology in about 37 percent. Others are related to drugs , autoimmune disease, infection such as hiv, endothelial injury, stem cell transplant etc. ...Read more

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Do people with thrombotic thrombocytopenia purpura have a lot of pain?

No usually: People with itp usually bleed more frequently following gently trauma, like a bump. In more severe forms, itp can be associated with gastric hemmorrages, which are painful, but this is rare. ...Read more

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Difference between idiopathic thrombocytopenia purpura and thrombotic thrombocytopenia purpura?

The are completely: Different. Itp is the autoimmune destruction of platelets and is managed with immunosuppression - the first line is usually prednisone. Ttp is the microvascular consumption of platelets (small clots). This can be associated with anemia, renal failure, ha and fever. It is a medical emergency and is managed with plasma exchange. ...Read more

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What is the treatment for thrombotic thrombocytopenia purpura?

Plasma transfusion: Ttp is due to deficiency of an enzyme normally present in blood. This enzyme controls the activation of platelets. The deficient enzyme is usually replaced by transfusing plasma and in severe cases by exchanging the patient's plasma with normal plasma. ...Read more

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What is idiopathic thrombocytopenia purpura?

Autoimmune disease: Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. Persons with the disease have too few platelets in the blood. Check this site: http://www.Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0001562/. ...Read more

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What is the treatment for idiopathic thrombocytopenia purpura?

What is the treatment for idiopathic thrombocytopenia purpura?

Steroids & surgery: Many cases of itp resolve with supportive care and corticosteroid treatment. In resistant cases, spleen, the site of platelet destruction, may be removed. ...Read more

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Is thrombocytopenia purpura as the same as blood dyscrasia?

Is thrombocytopenia purpura as the same as blood dyscrasia?

Different: Thrombocytopenic purpura (ttp) is an acute condition involving destruction of blood components including red cells and platelets and can be life threatening. Blood dyscrasia is a general term referring to a chronic or inherited blood compnent disorder such as hemophilia, leukemia, thalassemia, etc. ...Read more

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In the case of idiopathic thrombocytopenia purpura is pregnancy dangerous?

High risk pregnancy: It is something that is manageable, however. You should see a perinatologist for your high risk pregnancy to make sure your baby is okay and also see a hematologist through out your pregnancy- to make sure you and baby are okay. Your hematologist will be able to help and give you the necessary treatment as indicated- like-platelet transfusion, ivig, steroid etc. ...Read more

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Is it possible that I can get idiopathic thrombocytopenia pupura a second time?

Chronic disorder: Itp in adults is often a chronic disorder. There may be a period of remission which makes it appear that a person is getting the disease second time, when it in fact it was never cured. ...Read more

Brittany Chan Dr. Chan
5 doctors agreed:
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What is thrombotic thrombocytopenic purpura (ttp)?

Brittany Chan Dr. Chan
5 doctors agreed:

Platelet disorder.: Ttp is a blood disorder in which platelets form small clots. Formation of these clots uses up so many platelets that platelet count becomes low. The clots can get stuck in small blood vessels and cause damage to red blood cells, causing anemia. Other symptoms of ttp include fever, kidney failure, & neurologic problems. The biological cause of ttp is still uncertain. ...Read more

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Could someone tell me how many different kinds of Thrombotic thrombocytopenic purpura there is cause I had ttp and I thought there was just 1 kind?

Subtypes: You may have been born with low or poorly functioning ADAMTS13 (Upshaw's), or make an antibody to it, or otherwise have it inhibited, or get a TTP-like illness without a detectable inhibitor or mutation. It's good you're learning about your illness, and it's fortunate your physicians made the call. ...Read more

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What type of physician is best suited to treat thrombotic thrombocytopenic purpura?

What type of physician is best suited to treat thrombotic thrombocytopenic purpura?

TTP is managed by: A hematologist. Assistance may be needed from lab medicine or nephrology for plasma exchange therapy. Immunology, neurology and other consultants may be called in to help. ...Read more

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I have thrombotic thrombocytopetic purpura and I want to know if its safe to take birth control pills?

I have thrombotic thrombocytopetic purpura and I want to know if its safe to take birth control pills?

Avoid estrogen: Since ttp can sometimes be triggered by estrogen, you should probably avoid combination pills. The 'mini-pill' that has no estrogen might be an option. Talk with your gyn to come up with a safe, effective contraceptive plan. ...Read more

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Can children get thrombocytopenia?

Can children get thrombocytopenia?

Thrombocytopenia: in children is uncommon, but definitely possible due to a myriad of conditions. ...Read more

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Purpura (Definition)

Purpura are non blanching red or purple spots caused by bleeding beneath the skin. The spots do not blanch with pressure. They can be caused by platelet disorders, coagulation disordes, vascular ...Read more


Dr. Liawaty Ho
1,062 doctors shared insights

Thrombocytopenia (Definition)

A condition characterized by abnormally low levels of thrombocytes, also known as ...Read more