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Doctor insights on:
Thrombin Generation
1
What does an elavated partial thrombin time mean?
Coagulation test: Ptt measures intrinsic pathway of coagulation and will be prolonged if one or more of the factors are low. However, the common reason for prolonged PTT is heparin. ...Read more
2
, the patient does not require to do a pro thrombin test done?
Unclear question: Coagulation tests are ordered to evaluate bleeding disorders and are routine blood tests for most hospital labs. ...Read more
3
Anti Thrombin 3 deficiency had achy calves now getting sharp shooting pain from upper inner thigh to knee, worried if sign of another dvt?
Yes: You are at high risk of forming deep vein thrombi given your pro-thrombotic state. CAll 911 and go the nearest ER immediately for evaluation. ...Read more
4
Had a lupus anticoagulant test done all was normal except for a high thrombin time at 22.8 is this serious? Factor 5 also runs in my family.
Normally: a factor V deficiency can cause a prolonged thrombin time But your bleeding time and platelet count should be unaffected. Certain medications and other diseases could also cause elevated thrombin time. ...Read more
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5
Hi- blood test shows low thrombin time - 14 while the normal rate is between 16-20- does my blood tend to clot? Thank you
No: This is not a reliable measure of hypercoagulability. I would ignore it. You can talk about it with your physician if you wish. ...Read more
6
What is the role of thrombin in clotting?
Thrombin: is essential in the last common final pathway in clot formation ...Read more
7
What is the difference between thrombin and prothrombin?
Activation: Prothrombin{ II } is converted to Thrombin {IIa} ,the active form of the clotting enzyme by activated factor Xa and cofactor Va . This is the final common pathway for thrombosis. Thus Thrombin is just activated prothrombin. ...Read more
8
, the patient does not require to do a pro thrombin test done?
Unclear question: Coagulation tests are ordered to evaluate bleeding disorders and are routine blood tests for most hospital labs. ...Read more
9
If a partial thrombin time is high will the prothrombin also be high?
Not always: U mean: PTT vs. Pt? The partial thromboplastin time (PTT) measures the intrinsic pathway of the coagulation cascade; the protime (pt), the extrinsic. The pt is commonly affected by vitamin k antagonists (think: coumadin); the ptt, by heparin. Clotting factor deficiencies may also prolong both pt and ptt, but formal hematologist testing is required. ...Read more
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10
What to do if I have notes from my prof saying thrombin is used to dissolve the clot?
NO.: Thrombin causes clot or thrombus to form. Thrombolysis is dissolving clot-- a clot busting drug. ...Read more
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