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Doctor insights on: Thrombin Generation

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Is factor 7 gene mutation (heterozygote) thrombophila?

Is factor 7 gene mutation (heterozygote) thrombophila?

No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting). ...Read more

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What does an elavated partial thrombin time mean?

What does an elavated partial thrombin time mean?

Coagulation test: Ptt measures intrinsic pathway of coagulation and will be prolonged if one or more of the factors are low. However, the common reason for prolonged PTT is heparin. ...Read more

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Simultaneous detection of p24 antigen and antibody HIV 1and 2 cmia = 4th generation ag ab combo? Which means u have been tested for p24 /antibody ?

Simultaneous detection of p24 antigen and antibody HIV 1and 2 cmia = 4th generation ag ab combo?  Which means u have been tested for p24 /antibody ?

Yes and no...: The antibody portion of the test detects antibody to several HIV antigens in addition to p24. Probably you do have antibody to p24, but the test doesn't distinguish these various types. And it doesn matter. If your test is negative and it has been 4 weeks or more after your last possible exposure to HIV, the result is conclusive. ...Read more

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HIV1/2 P24 ab/ag 4th generation combo test, is it conclusive after 25 days of exposure?

HIV1/2 P24 ab/ag 4th generation combo test, is it conclusive after 25 days of exposure?

Probably yes: Officially, that test is conclusive at 28 days. It's probably conclusive at 25 days, but to be absolutely certain, have another test in a week or so. ...Read more

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Are any of the new anticoags useful for factor v leiden and lupus anticoag. Antibody. On lovenox (enoxaparin) 100mg bid. Venous and arterial clotting and pes. ?

Are  any of the new anticoags useful for factor v leiden and lupus anticoag. Antibody. On lovenox (enoxaparin) 100mg bid. Venous and arterial clotting and pes. ?

Maybe: The newer medications to prevent blood clots are not approved for use in the us for your condition. There is published research in europe showing that these medications can be used effectively for your type of problem. My personal bias is that you should wait until more research has been done. Your doctor can help advise you as to the status of this research as it evolves. ...Read more

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Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Factor viii inhibitor in hemophilia? What is a factor viii inhibitor?

Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

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Is this a lab error for Hepatitis B?: HBsAg(-), HBsAe(+), AntiHBc(+), AntiHBc IgM(-), AntiHBc IgG(-), AntiHBs(-). Repeated 3 more times with all (-)

Is this a lab error for Hepatitis B?: HBsAg(-), HBsAe(+), AntiHBc(+), AntiHBc IgM(-), AntiHBc IgG(-), AntiHBs(-). Repeated 3 more times with all (-)

False positive tests: With negative results on three more tests, almost certainly the positive results were false. This isn't necessarily a lab error, just a glitch in the biology of the test. That is, there probably is nothing the lab could have done to either cause or prevent it. In any case, you don't have hepatitis B. If potentially at risk, e.g. sexually active and not monogamous, get vaccinated. ...Read more

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Is the Rh factor in blood an antibody or antigen?

Is the Rh factor in blood an antibody or antigen?

Antigen: Rh factor is one the antigens present on red cells. Actually there are a number of subtypes of rh but the one people refer to is rh d antigen. See this site for more info. http://www.ncbi.nlm.nih.gov/books/nbk2269/. ...Read more

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Is antithyroglobulin antibody test the same as thyroglobulin antibody test?

Is antithyroglobulin antibody test the same as thyroglobulin antibody test?

Yes: Both address presence of antibody to the rhyroglobulin molecule made by thyroid gland. See this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/003557.htm. ...Read more

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Why is mhc class 2 more important in renal transplant than mhc class 1?

Why is mhc class 2 more important in renal transplant than mhc class 1?

Rejection Severity: Both are import ant and each can trigger rejection when the host is mismatched for any of these hla antigens. Recipients that develop antibodies to these phenotypes, in particular class ii dq--may have poorly responsive rejections. The antibody generated against class ii may derive from more resilient memory cells. Both are bad though. ...Read more

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Any known cases of 16 weeks negative HIV combo (architect) and RNA (cobas taqman v2) turning positive afterwards? Thanks

Any known cases of 16 weeks negative HIV combo (architect) and RNA (cobas taqman v2) turning positive afterwards? Thanks

Nope: There are no reported cases, and this is a pretty much impossible scenario. You can be sure you don't have HIV, assuming no other exposures more recently. ...Read more

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Help me.How long window period for HIV test of fourth generation ECLIA cobas 6000(combo) for HIV p24antigen & HIV antibody1 & 2 after exposure?

Help me.How long window period for HIV test of fourth generation ECLIA cobas 6000(combo) for HIV p24antigen & HIV antibody1 & 2  after exposure?

HIV testing: These antibody tests can take twelve weeks or more to be valid. If you are worried about an exposure the HIV rnaa test can b valid at 21days dater exposure. Please know that HIV infection can be prevented with post exposure prophylaxis...You just sve to act within 72 hours post exposure for it to work. ...Read more

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Which of these 3 hep c antibody screening tests(methodology)is the most accurate: Architect Anti-HCV, Advia Centauer HCV or Roche Eclia?

Which of these 3 hep c antibody screening  tests(methodology)is the most accurate: Architect Anti-HCV,  Advia Centauer HCV or Roche Eclia?

About equal: All three methods are FDA approved and about equally accurate. If you have concern about active Hep C infection, get a Hep C nucleic acid test. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Apart from elisa, which other immunoassay(s) can quantitative antigen analysis use?

Apart from elisa, which other immunoassay(s) can quantitative antigen analysis use?

See below: Rocket electrophoresis, radial immunodiffusion, conventional radio-immunoassy, densitometric scanning. There are many variations of ELISA itself. ...Read more