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Doctor insights on: Thrombin Antithrombin Complex

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Please help! what is the difference between anti-platelets (plavix) and anti-thrombins?

Please help! what is the difference between anti-platelets (plavix) and anti-thrombins?

Clotting: Clotting involves both cells that stick together and proteins that form a mesh. Anti-platelets work on the cells. Anti-thrombins work on the proteins. ...Read more

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Please help! what is the difference between anti-platelets (plavix) and anti-thrombins?

Clotting: Clotting involves both cells that stick together and proteins that form a mesh. Anti-platelets work on the cells. Anti-thrombins work on the proteins. ...Read more

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What is the difference between thrombin and prothrombin?

What is the difference between thrombin and prothrombin?

Activation: Prothrombin{ II } is converted to Thrombin {IIa} ,the active form of the clotting enzyme by activated factor Xa and cofactor Va . This is the final common pathway for thrombosis. Thus Thrombin is just activated prothrombin. ...Read more

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What happens if heparin affects the formation of thrombin then why pt is not prolonged?

What happens if heparin affects the formation of thrombin then why pt is not prolonged?

Two pathway measures: The PT can be with VERY HIGH doses of heparin but generally remember our coagulation system has two primary enzymatic pathways measured differently in the lab 1. Intrinsic system :measured by aPTT (activatted partial thromboplastin time) and prolonged by heparin and 2. Extrinsic system: measured by PT (prothrombin time) and prolonged by coumadin (warfarin).They then converge at the final common pathway. ...Read more

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What does an elavated partial thrombin time mean?

Coagulation test: Ptt measures intrinsic pathway of coagulation and will be prolonged if one or more of the factors are low. However, the common reason for prolonged PTT is heparin. ...Read more

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, the patient does not require to do a pro thrombin test done?

, the patient does not require to do a pro thrombin test done?

Unclear question: Coagulation tests are ordered to evaluate bleeding disorders and are routine blood tests for most hospital labs. ...Read more

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If a partial thrombin time is high will the prothrombin also be high?

If a partial thrombin time is high will the prothrombin also be high?

Not necessarily: Although these assays are quite similar, they are designed to test different components of the clotting cascade. The pt is used to monitor Coumadin (warfarin) and the PTT is typically used to monitor heparin. ...Read more

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Had a lupus anticoagulant test done all was normal except for a high thrombin time at 22.8 is this serious? Factor 5 also runs in my family.

Had a lupus anticoagulant test done all was normal except for a high thrombin time at 22.8 is this serious? Factor 5 also runs in my family.

Normally: a factor V deficiency can cause a prolonged thrombin time But your bleeding time and platelet count should be unaffected. Certain medications and other diseases could also cause elevated thrombin time. ...Read more

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Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Bad fit: Glad you're interested in basic pathology. Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis. ...Read more

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Would a deficiency in protein c or thrombin in the blood cause a wound to bleed longer or clot faster?

Look for.other.thing: Deci iency of protein C is rare and is aaaociatwd with increased risk of clotting Deficiency.of thrombin is also rare and when significant can be associated with increased bleeding However both conditions are unusual and often asymptomatic ...Read more

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What is the treatment if one person has all of these: protein s, protein c and anti thrombin III deficinecy?

What is the treatment if one person has all of these:  protein s, protein c and anti thrombin III deficinecy?

Unlikely situation: It is very unlikely for a person to be deficient in all of these proteins. However, deficiency of even one predisposes a person to abnormal clotting and long tern treatment with warfarin may be needed. ...Read more

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Hi I recently had testing do to a miscarriage. My protein c level was elevated at a value of 202. Also my anti thrombin 3 was elevated value 126. What if any underlying conditions will cause elevation. I have been told to follow up with a rheumatologist.

Hi I recently had testing do to a miscarriage. My protein c level was elevated at a value of 202. Also my anti thrombin 3 was elevated value 126. What if any underlying conditions will cause elevation. I have been told to follow up with a rheumatologist.

Autoimmune disorders: There are numerous autoimmune disorders that can contribute to increased risk of miscarriage. In addition there may be abnormal clotting disorders related to protein C & thrombin. A thorough evaluation with a specialist in autoimmune disorders is recommended to avoid a recurrence. Best of luck. ...Read more

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Thrombin-antithrombimTAT is 9.7, positive fibrin monomer, fibrinogen activity 451, homocysteine level 14.8. my doctor did not Say much. is this bad?

Thrombin-antithrombimTAT is 9.7,  positive fibrin monomer, fibrinogen activity 451, homocysteine level 14.8.  my doctor did not Say much. is this bad?

Depends.: High TAT occurs with activated clotting system. Causes vary--bleeding, blood clots, vascular disease, inflammation. High homocysteine can be associated with risk of clotting or vascular disease but also deficiency of B-12 or folic acid. If the rash is vasculitis it might explain much of what was found. Ask your doctor to explain it all when your biopsy is back. ...Read more

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Earlier this year I had prolonged PT and aptt, w/prolonged thrombin time. Mixing study did not correct. Dr thought lupus anticoagulant.Coagulation studies this mo show only prolonged Thrombin time. Have SLE. Do coagulation studies change like that?

What else changed: we also like to have two repeat positive tests to make a diagnosis. Were you on any diferent medications that might have had an effect on the tests. These results should be discussed with your rheumatologist. ...Read more