Doctor insights on:
Thrombin Antithrombin Complex
Is a simple coagulation lab test (PT/PTT INR & Fibrinogen) sufficient to diagnose Protein C,
&/or Factor V leidmen mutation disorders?
All could be: Depending on the spectrum of abnormalities associated with the syndrome all of these tests results could be abnormal. ...Read more
Are any of the new anticoags useful for factor v leiden and lupus anticoag. Antibody. On lovenox (enoxaparin) 100mg bid. Venous and arterial clotting and pes. ?
Maybe: The newer medications to prevent blood clots are not approved for use in the us for your condition. There is published research in europe showing that these medications can be used effectively for your type of problem. My personal bias is that you should wait until more research has been done. Your doctor can help advise you as to the status of this research as it evolves. ...Read more
Antibody to factor: Viii protein. People who are deficient in factor viii, i.e., have severe hemophilia, are treated with infusion of factor viii. Some make antibodies to factor viii and inhibit its function and are called factor viii inhibitors. Rarely non-hemophiliac can also develop such an inhibitor. ...Read more
Male 35,enlarge spleen 17 cm,high Beta-2 Glyco 1 IgM & Cardiolipin IgM, & DRVVT,normal INR & PTT , No clotting event, platelet fluctuate, is this APS?
It may be: You my have it but you need to repeat and confirm the results,also add a lupus anticoagulant test. You can discuss this with your physician or see a specialist. ...Read more
Yes: Omega 3 fatty acids have a mild blood thinning property. You list pulmonary embolism as one of your conditions. It definitely wouldn't be enough anticoagulant to treat that very serious condition. B-complex does not have anticoagulant properties. If you are taking coumadin/warfarin, tell your doctor about all the medications and supplements you are taking. ...Read more
Hbg, hct, rbc, plt, mvc, all at top of normal range. Does this ^ clotting risk? Hx: fact v leiden & aps. On lovenox (enoxaparin) 100mg bid
No: These values would not increase the risk. Normal is normal. ...Read more
Heterozygous for MTHFR, have high Protein C & Fact, VIII. Taking 3mg methylfolate for 3 mo, homocysteine normal . Reason to follow up w. hematologist?
No: Forgive my frankness. Most of us pathologists do not believe in this MTHFR screening being promoted by a lab to physicians worried about liability. A majority of folks test "abnormal" and are then offered questionable vitamin supplements. Reference ranges arbitrarily put several percent of healthies outside; high protein C and factor VIII are not worrisome especially if you feel well. ...Read more
Clotting factors: Vitamin k is used to create several factors in the clotting cascade (the system that ends in a blood clot). If vitamin k isn't there, then those factors are deficient, and blood won't clot as well. This is why newborns get a vit k shot, to avoid something called "hemorrhagic disease of the newborn.". ...Read moreSee 1 more doctor answer
What does high thrombin 14.5, prothrombin 22.7, APTT 79, APTT 1:1 NP 47 mean? SLE patient. Risk of bleed or risk of clots? C3-70,CH50- 22, C4-norm.
Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738 At your age you are unlikely to have myeloma. ...Read moreSee 1 more doctor answer
Serum b12> 1999 mma 0.4, homocysteine high 19. No folate (folic acid) or iron deficiency normocytic anemia not responding to procrit. Is this an absorption issue?
Anemia: can be caused by blood loss or bone marrow suppression as well. More information is needed ( how long have you had a normal iron, folate (folic acid) and b12 level. What is your reticulocyte count ? ( is your bone marrow producing new RBC's) ? How low is your HCT and has it come up or gone down with B12. Is the RDW elevated ( do you put out large and small RBC's at the same time? Any blood loss ? ...Read more
Platelet function test: collagen epinephrine normal, but ADP prolonged by 25 sec. Possible causes? Have normal CBC, PT, aPTT, CRP, d-dimer, comp met.
Aspirin exposure: This pattern of results could be from ingesting aspirin in some way. Aspirin (acetylsalicylic acid) is found in many things these days, including migraine meds, suppositories, fever/cough/cold relievers, & other OTC medications. Also, salicylate (salicylic acid), a prescription med for joint pain possible. Lastly, Plavix (clopidogrel) & other newer prescription meds aren't excluded. Happy hunting 4 u & ur doc! ...Read moreSee 1 more doctor answer
It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more
Tendency to clot: Factor v leiden is a hereditary abnormality of a clotting protein that increases your risk of forming clots, notably in the veins (phlebitis). If you are undergoing a procedure that would also increase this risk (surgery, prolonged immobilization), Lovenox (enoxaparin) might be used preventively. It is only for short-term use, and oral drugs such as warfarin would be used if you need long-term protection. ...Read more
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