Doctor insights on:
Thrombin Antithrombin Complex
Do you know are so effect, why are they not used instead of anti-thrombins in deep vein thrombosis ?
Garbled: Your question was garbled - please try again. ...Read more
Two pathway measures: The PT can be with VERY HIGH doses of heparin but generally remember our coagulation system has two primary enzymatic pathways measured differently in the lab 1. Intrinsic system :measured by aPTT (activatted partial thromboplastin time) and prolonged by heparin and 2. Extrinsic system: measured by PT (prothrombin time) and prolonged by coumadin (warfarin).They then converge at the final common pathway. ...Read more
Had a lupus test done and everything was normal except my thrombin time with a little high at 22.8 is this serious?
Hi- blood test shows low thrombin time - 14 while the normal rate is between 16-20- does my blood tend to clot? Thank you
Had a lupus anticoagulant test done all was normal except for a high thrombin time at 22.8 is this serious? Factor 5 also runs in my family.
Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?
Bad fit: Glad you're interested in basic pathology. Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis. ...Read more
In Feb had prolonged PT, thrombin, and APtt not corrected w mixing study. Started pentoxyphyline tid w 325mg aspirin daily. Recent study had only prolonged thrombin. Interpretation? What is significance of continued prolonged thrombin? SLE pt.
Would a deficiency in protein c or thrombin in the blood cause a wound to bleed longer or clot faster?
What is the treatment if one person has all of these: protein s, protein c and anti thrombin III deficinecy?
Hi I recently had testing do to a miscarriage. My protein c level was elevated at a value of 202. Also my anti thrombin 3 was elevated value 126. What if any underlying conditions will cause elevation. I have been told to follow up with a rheumatologist.
Autoimmune disorders: There are numerous autoimmune disorders that can contribute to increased risk of miscarriage. In addition there may be abnormal clotting disorders related to protein C & thrombin. A thorough evaluation with a specialist in autoimmune disorders is recommended to avoid a recurrence. Best of luck. ...Read more
Thrombin-antithrombimTAT is 9.7, positive fibrin monomer, fibrinogen activity 451, homocysteine level 14.8. my doctor did not Say much. is this bad?
Depends.: High TAT occurs with activated clotting system. Causes vary--bleeding, blood clots, vascular disease, inflammation. High homocysteine can be associated with risk of clotting or vascular disease but also deficiency of B-12 or folic acid. If the rash is vasculitis it might explain much of what was found. Ask your doctor to explain it all when your biopsy is back. ...Read more
Earlier this year I had prolonged PT and aptt, w/prolonged thrombin time. Mixing study did not correct. Dr thought lupus anticoagulant.Coagulation studies this mo show only prolonged Thrombin time. Have SLE. Do coagulation studies change like that?
What else changed: we also like to have two repeat positive tests to make a diagnosis. Were you on any diferent medications that might have had an effect on the tests. These results should be discussed with your rheumatologist. ...Read more