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Doctor insights on: Thickened Uterine Lining And Ovarian Cysts While On Tamoxifen

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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Is there a relation between ovarian cysts and abnormal uterine lining thickening?

Is there a relation between ovarian cysts and abnormal uterine lining thickening?

Sometimes: Most ovarian cysts result from how an egg develops. Sometimes an egg doesn't release normally and the hormones can become mixed up. This is most common in adolescents and in women approaching menopause. You should talk to your gyn provider about what you are experiencing and how to treat it. ...Read more

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What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening . Thanks

What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening .   Thanks

Letrozole: Tamoxifen for 5 years followed by Letrozole would be an option. However, technically you are still premenopausal so not an option. Another treatment which is controversial is to have your ovaries removes. There is data on 10 years of tamoxifen now but you may not want to do this. The other option would be observation. Hope this helps. ...Read more

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On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

Not necessarily: There are multiple issues in your question and it would be best for you to discuss your symptoms with the doctor presribing your tamoxifen in conjuction with your gynecologist. ...Read more

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My FSH was 2.7, estrodial was1340, was on tamoxifen, had a couple of ovarian cysts. Had mastectomy for 1mm bc.Grade 3. Was a bilateral ooph necessary

My FSH was 2.7, estrodial was1340, was on tamoxifen, had a couple of ovarian cysts. Had mastectomy for 1mm bc.Grade 3.  Was a bilateral ooph necessary

Need more info: Your fsh indicates you are not yet in menopause and the cysts could be worrisome. Have you done brca testing or ova1 testing for the cysts? Your doctor may be trying to be proactive and remove the ovaries prior to a potentially worse situation. No real way to accurately determine if someone has ovarian ca without pathology, only an educated guess by ultrasound and lab testing. ...Read more

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Ultrascanning abdomen report says - retroverted bulky uterus with thickened endometrium, left simple functional ovarian cyst. What does this mean?

Ultrascanning abdomen report says - retroverted bulky uterus with thickened endometrium, left simple functional ovarian cyst. What does this mean?

See GYN: The thickening of the endometrium (lining of the uterus) needs to be checked out. Usually the doctor will do an endometrial biopsy to see if the cells are normal or abnormal. A functional ovarian cyst is nothing to be concerned about and is just related to ovulation usually. ...Read more

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Abnormal pap smear-enlarged uterus(11cm)left complex ovarian cyst(new since 7/31/15)and thickening endometrium(10mm)Possibly cancer?Lower abd pain24/7

Abnormal pap smear-enlarged uterus(11cm)left complex ovarian cyst(new since 7/31/15)and thickening endometrium(10mm)Possibly cancer?Lower abd pain24/7

A cornucopia: You have 5 major reasons for seeing a GYN MD now. This is the "horn of plenty" of symptoms that need immediate evaluation. Surgery may be in your immediate future after biopsy and evaluation. ...Read more

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Recently had a CT scan is it possible for a remarkably thickened sigmoid colon, bulky uterus, and ovarian cyst over 5cm to be related? Concerned

Recently had a CT scan is it possible for a remarkably thickened sigmoid colon, bulky uterus, and ovarian cyst over 5cm to be related? Concerned

Guessing: This is hard to call form just a description of CT, not knowing any other clinical facts. Can say: 1) the bulky uterus is 100% unrelated to the other findings, the thickened sigmoid "may" be related to the ovarian cyst or vice-versa. A doctor who knows your whole history and exam could answer these for you, can't say more online. Good wishes ...Read more

Cyst (Definition)

A cyst is a structure or mass that consists of a cellular lined sac. It is typically filled with fluid but may be filled with solid material. It can be congenital, traumatic, or acquired. They may develop nearly anywhere in the body and usually require complete excision for eradication or they are likely to recur. Fluid filled sacs that are not cellular lined ...Read more


Uterus (Definition)

The uterus is a muscular organ in a woman's pelvis where the the fertilized egg attaches ...Read more