Doctor insights on:
Thiamine Deficiency Anemia
I was diagnosed with wernickes encephalopathy after a thiamine deficiency in march 2011 post gastric surgery am I unlikely to recover fully?
Recent info may help: All the B vitamins have limited absorbtion through the gut, so take thiamine 3 times/day. One form of thiamine was designed go through the blood-brain barrier, called sulbutiamine, a dimer of two thiamine molecules; some individuals may have normal blood levels, but abnormally low brain levels, and it may help. The Japanese invented it--30% of Japanese died from thiamine deficiency in early 20th C ...Read more
Please help! What is the association between metabolic acidosis caused by high levels of lactate with thiamine deficiency?
Possible mitochon-: Rial disorder. Thiamine-vitamin B1-is a cofactor for energy production, which occurs primarily in mitochondria. When mitochondria become sick, anaerobic metabolism occurs, producing lactic acid. The most recognized cause of thiamine deficiency is alcohol. Thiamine is destroyed by sulfites which are used commonly by the food industry for preservatives. I suggest a clinical genetics consultation ...Read more
Is it unlikely i'll make a full recovery? I was diagnosed with wernicke's after thiamine deficiency in march 2011
No: Wernicke´s is temporary as long you stop drinking. ...Read more
Yes.: Pernicious anemia is the most common reason for unexpected B12 deficiency. Lack of B12 can cause both anemia and neurological damage. The latter includes numbness, gait problems, and dementia. The neurological findings can occur before there is any anemia, or vice versa. The anemia will reverse with treatment. The neurologic problems may not correct completely with B12 treatment. ...Read more
Yes it can: Having a virus can suppress the bone marrow, making an anemia worse, no matter what the cause. The virus basically interferes with the body's ability to produce new red blood cells. It will not make the iron deficiency worse, but it will make the anemia worse (and the symptoms from being anemic). ...Read more
Related: Technically, pernicious anemia (pa) is due to low B12 levels caused by changes in the stomach resulting in decreased ability to absorb the B12 from a lack of something called "intrinsic factor." there are other causes of B12 deficiency that technically are not pa. Today, tests can find B12 deficiency before someone has symptomatic anemia so deficiency by itself is not always pa. ...Read more
Severe Fe deficiency anemia, recent CBC showed monocytes 12.6% (reference 2-8). Is this abnormal? The monocyte count was 0.62.
Treat Fe deficiency:
An elevated monocyte count is not material. I trust that you are taking oral iron supplement and multivitamins to correct iron deficiency.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more
2 years ago, I was told my B12 deficiency could lead to pernicious anemia. I stopped the B12 pills, my symptoms match, can I have this? B12 now fine.
Many: There are many causes for anemia (RBC), just list a few: 1) decreased production due to not enough nutrition, B12/folate/iron def, or bone marrow diseases or bone marrow suppression from drugs/radiations or due to chronic kidney disease (not enough epoietin); 2) increased destruction: intravascular or extravascular hemolysis; 3) blood loss or chronic disease/cancer or some congenital diseases. ...Read more
Not if treated: It takes a very long time for you to get near death from B12 deficiency. The treatment is so simple and effective, why chance it? ...Read more
There are many. ....: Causes of anemia, both constitutional and acquired. Fe deficiency is the most common cause of anemia in the us and making that diagnosis is relatively straight forward. However, fe deficiency anemia is not a diagnosis, in and of itself, but rather is a finding with an underlying cause that must be identified. Correcting the fe deficiency without correcting its source will only lead to recurrence. ...Read more
Chronic diseases: Such as sickle cell, thalassemia, , GI bleed, cancer, inflammatory bowel disease, renal disease can also cause anemia. Prenicious anemia (due to autoimmune destruction of special stomach cells), folate (folic acid) and B12 deficiencies are other causes. Talk with your docotr if special testing is required to determine etiology of anemia and if colonoscopy is required. ...Read more
Cell membrane damage: Pyruvate a kinase deficiency results in reduced ability of red cells to make ATP -the "energy source" of cells. Atp is also necessary to protect cells from damaging compounds such as free radicals. With decreased energy supply the cell is not able to maintain appropriate concentrations of electrolytes and fluids, becomes distorted or stiff, and then is destroyed in the spleen or liver. ...Read more
I found out that I have anemia (iron deficiency kind). How quickly will I be able to get enough iron back into my system?
Depends: There are many different ways to get iron. Dietary iron will help but is probably the slowest method. Oral iron supplements can vary in their absorption but do work for most people. Also for those who don't respond to oral iron or need their iron improved in a hurry there are injectable and IV iron preparations which can be give. Ask your doctor which is right for you. ...Read more
Fe deficiency anemia: Occurs when fe intake is not adequate to meet the needs of the body for red cell production. Indeed, it is not a diagnosis unto itself, but rather an indication of another problem to be discovered and corrected to avoid recurrence. Work with your doctor to address the cause of your fe deficiency state, and correct it as well as the fe deficiency state itself. Good luck. ...Read more
Stop ongoing losses: help heavy menstrual bleeding, fix ulcers, cure leukemia.
Build iron supplies: red meat, egg yolk. Mollusks (oysters, clams, scallops)
turkey or chicken giblets beans, lentils, chick peas and soybeans, liver
artichokes, black strap molasses
iron-enriched cereals and grains
dried fruit (prunes, raisins
iron absorption enhansed by taking with vitamin c rich drink: orange juice. ...Read more
Severity and cause: Will depend on how severe it is and whether you are pregnant or not. If you only have mild deficiency-you probably don't have any symptom. If severe enough, tired, fatigue, dizziness, chest pain, shortness of breath can be the symptoms. In pregnancy iron is very important for the fetus. It is crucial to know what is the cause. Bleeding? Malabsorption, cancer? Etc- this needs to be found out. ...Read more