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Doctor insights on: Therapath Skin Biopsy

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Skin cancer biopsy question? How deep is it?

Skin cancer biopsy question? How deep is it?

Just deep enough!: Sorry to be a smart ass but the depth of the biopsy varies with the kind of skin cancer, but rarely goes deeper than the thickness of the skin. The area will be numbed, so, fortunately, it rarely matters to the patient how deep the biopsy extends. Biopsies of shallow lesions are usually shavings of a partial thickness of skin; deeper lesions often are punched, taking a small full-thickness piece. ...Read more

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Dr. Patrick Sweet III
121 doctors shared insights

Skin Biopsy (Definition)

A skin biopsy is a way of getting a sample of skin for diagnostic purposes. There are two main ways of doing this. Shave biopsy. A blade is used to cut across the skin. It can leave a scar a bit like a golf divot. Punch biopsy. A device that looks like a little cookie cutter is used to take a cylinder of skin. This goes all the way through the skin and is ...Read more


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Brief me on skin cancer and skin biopsies.

Brief me on skin cancer and skin biopsies.

What is the Question: Please tell us what you want to know about skin biopsies? Skin Cancer is of 3 types: Basal cell cancer and squamous cell cancer are relatively slow growing and considered rather benign in their behavior and are nearly 100 cured with a simple excision. Melanoma is less common, yet much more serious as a cancer as it tends to spread inside the body and can cause death once it spreads beyond the skin ...Read more

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What it's mean: "closed skin Subcutaneous Tissue Biopsy procedure?

Under skin: It means the stitches are in tissue beneath the skin where you cannot see them. No suture removal will be needed. ...Read more

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Is a fine needle or excisional biopsy better to diagnose lymphoma?

Is a fine needle or excisional biopsy better to diagnose lymphoma?

Excisional: Excisional biopsy is more accurate for diagnosis of lymphoma, because the samples are much larger. Fine needle aspiration (fna) can make the diagnosis, and is much less invasive - however, the sample is much smaller, and can miss the involved portion of the lymph node. ...Read more

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May i know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?

May i know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?

Get 2nd opinion: A pathologist who trained at one of my institutions self-diagnosed a sarcoma and had his arm amputated, only to discover later it was nodular fasciitis, which is very benign. I was trained by some of the great pathologists and even they said they'd never call nodular fasciitis without a second pathologist agreeing. I'd suggest showing 3-4 of us pathologists. Good luck. ...Read more

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Pigmented lesion ..Back...Biopsy sheets dermoepidermal junction nests pigmented bland looking round cells &nuclei.......Whats diagnosis plz?

Pigmented lesion ..Back...Biopsy sheets dermoepidermal junction  nests pigmented bland looking round cells &nuclei.......Whats diagnosis plz?

Sounds benign: This description sounds like a benign mole or what a pathologist would call a junctional nevus. There should be a final diagnosis on the report in addition to the description. Doesn't sound worrisome or atypical to me. ...Read more

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Does sentinel lymph biopsy for melanoma work well?

Does sentinel lymph biopsy for melanoma work well?

It does: The sentinel lymph node procedure is the most significant prognostic tool for melanoma. It should be performed in the hands of an experienced surgeon such as a surgical oncologist, ...Read more

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Needle biopsy? How does a needle biopsy work? Why would some one get a needle biopsy?

Needle biopsy? How does a needle biopsy work?  Why would some one get a needle biopsy?

Needle Biopsy.: Large bor needle is inserted into the object of interest then removed with a piece of tissue remaining inside the needle. A needle biopsy is cheaper, faster, generally safer and sometimes the only alternative to major surgery. In medicine we always try to do the least invasive and dangerous test first. ...Read more

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Skin biopsy take sample from foot or hip?

Skin biopsy take sample from foot or hip?

Depends: Usually skin biopsy is taken from the site of the lesion. If the biopsy is for a systemic disorder like lupus, then it may not matter where it is taken from. Neither foot nor hip are usual sites for biopsy, unless the lesion happens to be there. ...Read more

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Peripheral neuropathy symptoms for 3 years. multiple EMG/NCV/Skin biopsy negative. FINALLY repeat skin biopsy WAY below normal. is this unusual?

Peripheral neuropathy symptoms for 3 years. multiple EMG/NCV/Skin biopsy negative. FINALLY repeat skin biopsy WAY below normal. is this unusual?

Well sort of: Like I tell patients all of the time, if you have diabetes or a vitamin deficiency, then pinning down the cause of a neuropathy is easy. Anything else can be quite a challenge and there are literally hundreds of causes for neuropathy otherwise. I'm sure at this point you had a thorough work up, but seeking quaternary care (e.g. Mayo Clinic) is not inappropriate at this point ...Read more

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Hi, My skin biopsy shows "hyperkeratosis and acanthosis of the epidermis and in dermis perivascular lymphocytic infitrate" will Ciclosporin help me?

Hi, My skin biopsy shows "hyperkeratosis and acanthosis of the epidermis and in dermis perivascular lymphocytic infitrate" will Ciclosporin help me?

Not specific enough: This sounds like a fairly benign pathologic description, so I doubt you would need cyclosporine, unless there is other information, or there has been no response to more benign therapies ...Read more

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Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy  give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read more

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Thyroid nodule with rare cluster ofoverlapping enlarged cells, grooves and pale chromatin. Rebiopsy or surgery? 2.9x1.1x2.2 cm

Thyroid nodule with rare cluster ofoverlapping enlarged cells, grooves and pale chromatin. Rebiopsy or surgery? 2.9x1.1x2.2 cm

You have a choice: The results you are sharing are benign. The cells were likely from a fna biopsy. The size of your thyroid nodule meets criteria for removal, greater than 2.5 cm. Okay to talk to your doc and your surgeon about risk/benefits of waiting a few months with repeat ultrasound versus surgery now to remove one side of your thyroid. Good luck. ...Read more

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Melanocytic Nevus with arch disorder and mild cytologic atypia of melancytes found from mole shave biopsy. what is the treatment for this?

Melanocytic Nevus with arch disorder and mild cytologic atypia of melancytes found from mole shave biopsy. what is the treatment for this?

Removal of nevus: Excision of mole is preferred method , it gives complete picture , not missing any area of potential malignant cells . Good news you don't have , but have atypical cells , so speak to your doctor for possible excision of whole mole and analyzing ( biopsy ) it. ...Read more

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Had punch biopsy done on rash in '09. Results: "early lesion of connective tissue disorder." what f/up is suggested?

Had punch biopsy done on rash in '09. Results: "early lesion of connective tissue disorder." what f/up is suggested?

Rheumatologist: Talk to a rheumatologist to confirm your diagnosis. Blood tests might be needed. A minimum of a yearly follow up is needed provided no other symptoms are present. ...Read more

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Biopsy:Cervical squamous mucosa w/ reactive epithelial changes and hyperkeratosis.Endocerv. curetting:benign endocerv. tissue.Can you help understand?

Biopsy:Cervical squamous mucosa w/ reactive epithelial changes and hyperkeratosis.Endocerv. curetting:benign endocerv. tissue.Can you help understand?

Doctor Speak: There is nothing scary in those results. "Benign endocervical tissue" means there is normal, non-cancerous tissue from the endocervix. "Cervical Squamous mucosa" is simply normal skin from the outer cervix. "Reactive epithelial changes" mean that they see evidence of a reaction by the skin to irritation or injury. Hyperkeratosis is an increased amount of keratin in the skin. ...Read more

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Does all melanoma require lymph node biopsy and drug treatment?

Does all melanoma require lymph node biopsy and drug treatment?

Nope: Only melanomas that are thicker than 1mm or with worrisome features require a lymph node biopsy. Drug therapy is reserved for patients with metastatic melanoma. ...Read more

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How accurate is a skin biopsy?

How accurate is a skin biopsy?

Skin biopsy: This really depends on what is being biopsied. For a "nodule" or "bump," to rule out cancer, a biopsy is usually likely to give a very accurate diagnosis, although some early forms of cancer can be difficult. Biopsies of "rashes" are more tricky. Sometimes the histology is classical, and a very specific diagnosis can be made. But sometimes the biopsy has a non-specific appearance. ...Read more

Dr. Suzanne Galli
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more