Doctor insights on:
Yes: Beta thalassemia disease is prevented if beta thal carriers do not have children with one another (if they have children together, some children will be normal, some carriers, and some have disease). The other, less desirable way, is to test fetuses during pregnancy and abort the fetuses who have beta thal major. ...Read moreSee 1 more doctor answer
I went for blood test and the doctor said I have lack of blood and have the symptom of thalassemia disease. What is the other symptom of thalassemia?
No: It affects red blood cells. Not white blood cells or any other component of the immune system. ...Read more
Why is it that alpha and beta -thalassemias result in more clinically severe diseases than other types of thalassemia?
Used for blood cells: Alpha globulin (made by the Alpha genes) and beta globulin (made by the beta genes) are the 2 globulin molecules needed to make normal adult hemoglobin (the red stuff in normal red blood cells). Mutations that prevent Alpha and beta globulin production will cause severe symptoms, but other mutations may not be as noticeable if the proteins the other genes make are not as crucial to life. ...Read moreSee 1 more doctor answer
Genetic disorder: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3237252/ "the disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy. "...."careful tailoring of treatment is required for each patient, and that therapeutic approaches should be re-assessed over-time." not curable..Look at website-. ...Read more
I've beta thalassemia minor and my husband have e trait. Is it necessary to test our baby? Is there any chances to get disease of our baby?
Not likely: Unless your infant is showing signs of anemia, you may do an hemoglobin electrophoresis at any time after several months of life. Fetal hemoglobin (normal) is usually present in decreasing amounts until around 18 months. Once the electrophoresis is done, you will know your baby's hemoglobin type. Discuss with your doctor. ...Read moreSee 1 more doctor answer
How do we know which baby will be suffered from hgb e/beta thal disease? Any chances about my 1st baby?Bcoz we are e trait and beta thalassemia couple
It's random: Each time you conceive a child, a random assortment of genes from each parent goes into making up junior's genome. This is basic biology but still often needs to be reviewed. It's good for folks with any thal variant to take enough folate, but you should be taking that iron if and only if you are actually iron deficient or clearly need to supplement. Glad you're learning and proactive. Good luck. ...Read more
After how much time does the child suffering from thalassemia major show symptoms of disease after birth?
6-8 months for beta: Alpha thalassemia major is generally fatal before birth, with just rare cases born alive. Beta thalassemia major babies look normal at birth because fetal hemoglobin doesn't need beta globulin. As fetal hemoglobin goes away and adult hemoglobin starts being made, the baby will feel the effects of his lack of beta globulin. Symptoms start after the first 6-8 months of life. ...Read more
No: The normal parent will give his or her normal gene to their baby. That means the baby will have one abnormal and one normal gene, meaning the baby would be a "carrier" of one bad gene and not suffer the actual disease. The only way the baby would end up with 2 abnormal genes is if the gene from the normal parent got altered by a new mutation... Which is unlikely to happen. ...Read more
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