Top
30
Doctor insights on: Thalassemia Causes Leukemia

Share
1

1
Does alpha thalassemia causes leukemia?

Does alpha thalassemia causes leukemia?

No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read more

Dr. Liawaty Ho
1,149 Doctors shared insights

Leukemia (Definition)

A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more


2

2
How are beta-thalassemia and leukemia related?

How are beta-thalassemia and leukemia related?

Unrelated: Beta thal is a congenital disease-where there is defect on the beta- globin inside the rbc. The severity of the disease depends on how many b- globin affected. Beta thal major is very debilitating- tansfusion dependent and only transplant can perhaps cure it. Leukemia however is malignancy of the progenitors of the white cells-in bone marrow. Different types of leukemia-acute vs chronic leukemia. ...Read more

4

4
I had leukaemia (ALL) 11 years ago and now have been diagnosed with alpha-thalassemia - are the two linked? I'm white British so not typical for this

I had leukaemia (ALL) 11 years ago and now have been diagnosed with alpha-thalassemia - are the two linked? I'm white British so not typical for this

No association: Although weird that they didn't note this before. I assume you have been diagnosed with alpha thalassemia trait, not the disease. ...Read more

5

5
What are the main causes of leukemia?

What are the main causes of leukemia?

Random mutations...: Occur in our body's cells because they are not able to correct all of the millions of DNA damage events that naturally occur during our life. In the event that a bone marrow progenitor cell gets hit with an unlucky series of mutations then a leukemic cell will be made, and grow out of control. Familial susceptibility, or exposures (e.g. chemotherapy, radiation, or benzene) may increase this risk. ...Read more

6

6
What are the causes of leukemia in children?

What are the causes of leukemia in children?

Unknown: Most leukemias in adults and children do not have a specific etiology. Some leukemias in children can be linked to genetic abnormalities like down's syndrome, neurofibromatosis, bloom syndrome, and others. Ethnicity may play a role in all, hispanic children tend to have higer risk. High birth weight has been associated with higher risk though really this is unclear. Other factors are inconsistent. ...Read more

7

7
Which forms of leukemia are caused by a mutation?

Which forms of leukemia are caused by a mutation?

Most are due to muta: Mutations are common in all cancers. In Leukemia the very first mutation (Single mutation, causing cancer was discovered in Chronic Myelocytic Leukemia (CML). In most other Leukemias, there are multiple mutations present once we have learned how to search for them by Genomic profiling. ...Read more

9

9
I want to know what's the main cause of childhood leukemia?

I want to know what's the main cause of childhood leukemia?

Unknown: Just like most other cancers, the cause of leukemia is unknown. ...Read more

10

10
Does gcsf injections 2 a week for 2 1/2 years cause leukemia?

Does gcsf injections 2 a week for 2 1/2 years cause leukemia?

Probably not.: Gcsf is given to raise the neutrophil count. Long term use usually is for severe chronic neutropenia with high risk of infection. While gcsf use has been reported in patients who have subsequently developed leukemia, so far such reports are only in people whose underlying disease already confers such a risk. There is no convincing evidence that gcsf increases that risk. ...Read more

11

11
Can leukemia affect the organs in your body, or is it caused by chemotherapy?

Can leukemia affect the organs in your body, or is it caused by chemotherapy?

In general: Leukemia does not cause organ insult in and of itself. You are correct - chemotherapy can lead to specific organ issues, as could leukemia associated infections. ...Read more

12

12
Will leukemia cause low hemoglobin levels? How quickly does it progress if acute?

Will leukemia cause low hemoglobin levels? How quickly does it progress if acute?

Unlikely: Unlikely acute leukemia, plz see a hematologist. Anemia has many causes at your age most common being iron deficiency. Acute leukemia without therapy is a fatal disease. ...Read more

13

13
My 12 year old's ANC has varied from 1341 down to 918, up to 2378 down to 805 over 6mths. If it were caused by leukemia would it go up and down?

My 12 year old's ANC has varied from 1341 down to 918, up to 2378 down to 805 over 6mths. If it were caused by leukemia would it go up and down?

No.: Leukemia will cause a low neutrophil count. And over the course of 6 months, leukemia will be very obvious. It would not only cause a low neutrophil count at that point. It would also cause low platelets (which causes bruising and bleeding) and low hemoglobin (which causes fatigue). ...Read more

14

14
What causes leukemia?

What causes leukemia?

Leukemia cause: We don't know for sure. Leukemia develops as the consequence of a series of genetic changes in blood cell offsprings. These changes alter normal growth and differentiation of the cells, resulting in an accumulation of abnormal, immature blood cells in the bone marrow and peripheral blood. Exposure to chemicals, radiation, tobacco, or chemotherapy, infection, etc have been associated with leukemia. ...Read more

15

15
Which type of pain does leukemia cause?

Which type of pain does leukemia cause?

Rarely causes pain: It is uncommon to have pain as a symptom of leukemia. But if you have it then it is likely to be from the bones, most often from the pelvic/low back area. But you should know what type of leukemia you are dealing with (?) as there are 4 different types which can be either acute or chronic leukemia, with entirely different symptoms from one to the other (s). ...Read more

17

17
In what way can chemicals cause leukemia?

See below...: Exposure to certain chemicals like benzene or formaldehyde may increase the risk for cancer including leukemia. This is probably due to the mutagenic effect of these agents, meaning they can induce mutations in otherwise normal cells resulting in abnormal cells that can become cancerous; however, the process is usually multifactorial and other conditions need to be met to develop cancer. ...Read more

18

18
Does leukemia usually cause many symptoms?

Does leukemia usually cause many symptoms?

Varies: Acute leukemias usually cause symptoms that bring a patient in to a doctor or emergency room. Chronic leukemias are often found incidentally when a blood count is ordered and abnormalities are identified. ...Read more

19

19
Are emf and emi known to cause leukemia in young kids?

Are emf and emi known to cause leukemia in young kids?

No: Dr. Legha is right but has understated matters. After forty years of hype, there's still no reason to think these cause cancer other than some bad studies based on patient and family recall -- you can get ANY "scare story" you want that way. I'd be angry with the people who gave you this disinformation. ...Read more

20

20
What is the defect in the cell cycle that causes leukemia?

The cell cycle: ...is activated in the immature "blast" cells of acute leukemia. This is not so much a defect, as it is also a normal attribute of immature blood cells. A major problem is the lack of maturation of these cells into normal non-dividing blood cells. Various transcription factors are mutated and these may cause increased proliferation. CLL is characterized by decreased apoptosis (cell death). ...Read more

21

21
What external chemicals can cause leukemia and where are they found?

What external chemicals can cause leukemia and where are they found?

Benzene products: Benzene used in petrochemical industry is one know cancer causing agent. But most cases of leukemia come out of the blue, without any obvious or known cause. It is more of an accident of nature. I doubt you will be able to lay a finger on the cause of your leukemia. ...Read more

23

23
What is chronic eosinophilic leukemia? What causes it?

Variant of CML: This is a variant of chronic myelogenous leukemia. It is the consequence of an acquired mutation in the marrow, but what causes THAT is unknown. ...Read more

24

24
Purpura only cause in leukemia or is there any more diseases?

Purpura only cause in leukemia or is there any more diseases?

Lots of causes: Are you on any new medicines or supplements? Purpura are raised red/purple spots on the skin. There are many causes of purpura, some are serious. Discovering the cause may take some time, but it is important to find out why. Here's a good discussion of the causes and the workup:
http://www. Nlm. Nih. Gov/medlineplus/ency/article/003232.htm

Never worry until you have to. Wastes energy. Go play! ...Read more

25

25
How severe are the possibilities of leukemia caused by radiation?

How severe are the possibilities of leukemia caused by radiation?

Not a high: Risk if you are talking on a percentage of all patients receiving therapeutic radiation, but secondary acute myeloid leukemia does occur and late (many years later) chronic myeloid leukemia can be seen after radiation exposure. ...Read more

26

26
Can you please discuss cause, symptoms, treatment for chronic myologic leukemia?

Can you please discuss cause, symptoms, treatment for chronic myologic leukemia?

SIMPLE ANSWER: There is no specific symptom. Symptoms vary, for example: fevers, night sweats, weight loss, fatigue, weakness and shortness of breath to name a few. Initial best test is a: CBC - complete blood count. For CML there has been a chromosomal translocation known as bcr/abl resulting in what is known as the philadelphia chromosome. Treatments are oral tyrosine kinase inhibitors that target c-kit. ...Read more

27

27
Do they use radiation to treat leukemia, even though radiation also causes leukemia?

Do they use radiation to treat leukemia, even though radiation also causes leukemia?

Yes, in some cases: Radiation can be used to treat leukemia in certain situations. It can be used as part of the leukemia treatment in preparation for a stem cell transplant. It can also be used to treat leukemia that has spread to the spinal fluid or formed a mass of leukemia cells outside the bone marrow. ...Read more

28

28
What causes leukemia? What is the treatment like? Is it a long term and continuous treatment? Is it going to cost a lot?

Depends: There are many types of leukemia and many types of treatment for each type. Some require just observation alone, otheres require aggressive, multiagency chemotherapy. Treatment can be quite expensive. Your best bet is an academic center that has extensive experience correctly diagnosing, treating and managing leukemia. ...Read more

29

29
Can a spleen removal cause leukemia?

Can a spleen removal cause leukemia?

No: I know of no association of splenectomy surgery causing leukemia. Some blood disorders do have spleen surgery to resolve an enlarged spleen or low platelets (thrombocytopenia). ...Read more

30

30
Could spleen removal cause leukemia?

No: Spleen has no connection to causing leukemia. So its removal can not cause leukemia. ...Read more

Dr. Michael Engel
272 Doctors shared insights

Thalassemia (Definition)

An inherited condition ...Read more