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Doctor insights on: Thalassemia Bodybuilding

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What is thalassemia?

What is thalassemia?

Thalassemia: Thalassemia is a deficiency in the production of one of the globin chains (alpha or beta) that make up hemoglobin. Normally synthesis of these is balanced. When imbalanced, one globin accumulates relative to the other forming inclusions that are damaging to the red cells that contain them. There are many thal variants that manifest a wide severity of symptoms from none to transfusion dependence. ...Read more

Dr. Heidi Fowler
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What is thalassemia?

What is thalassemia?

Familial blood trait: Thalassemia runs in families. It is caused by variations (mutations) in DNA, which is then passed on to future generations. There are many variations in the DNA (genes) that code for hemoglobin molecules inside red blood cells. Some of these variations cause the hemoglobin production to be very slow, so blood cells stay too small because they can't form enough hemoglobin to grow to normal size. ...Read more

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What exactly is thalassemia?

What exactly is thalassemia?

See below: Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia. ...Read more

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How is thalassemia inherited?

How is thalassemia inherited?

From Mom and/or Dad: Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells. Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad. ...Read more

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How was thalassemia discovered?

How was thalassemia discovered?

Microscope: Thalassemia causes microcytic anemia - tiny red blood cells. ...Read more

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I was wondering what are the effects of thalassemia?

I was wondering what are the effects of thalassemia?

More info needed: Effects are entirely dependent on what form of thal you have. Thal minor is not usually a problem, but causes a problem for a baby born to parents who both have thal minor and the baby received a gene for thal from each parent--this produces a condition known as thal major, and requires transfusion therapy, usually monthly. Iron overload from transfusions and extramedullary erythropoiesis--. ...Read more

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Is thalassemia fatal?

Is thalassemia fatal?

Very rarely: Thalassemia comes in many degrees of severity. Patients with Alpha or beta thalassemia minor are mildly anemic but typically are very healthy and have a normal lifespan. Beta thalassemia intermedia and major, and 3 gene Alpha thalassemia are increasingly more severe and require more intervention, but patients who receive good care and follow their doctor's instructions can lead a normal life. ...Read more

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Cure for thalassemia?

Cure for thalassemia?

Marrow Transplant: Currently the only way to "cure" thalassemia is to replace enough of the marrow cells that make red cells/ hemoglobin to result in normal oxygen carrying and delivery as well as reduced numbers of fragile red cells. And the only way to do this is by bone marrow transplantation. ...Read more

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Is thalassemia curable?

Bone marow transplan: Just like what dr. Kwok said- the only thing that can cure thalassemia major is allogeneic bone marrow transplantation. Otherwise, the rest of management of thalassemia major is mainly supportive care with blood transfusion, iron chelating agent, and other treatment to reduce the complication from iron overload. No major treatment needed for thalassemia minor or trait -discuss with your doctor. ...Read more

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Is thalassemia treatable?

By blood transfusion: In thalassemia patients who are very anemic, and have symptoms from their anemia, periodic transfusions is the usual treatment. If they have had many transfusions, their bodies will get iron overload from the past transfusions (chelation therapy to remove iron may be needed). The cure for thalassemia major is through bone marrow transplantation. ...Read more

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What is beta thalassemia?

What is beta thalassemia?

Beta thalassemia: Is a genetic defect of impaired hemoglobin production, resulting in a varying degree of anemia. ...Read more

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What is trait thalassemia?

Ok: Thal trait is different from thal major--the trait has one chromosome for this disease and the full disease means each parent gave the trait and that the child got a thalassemia gene from each parent which can cause thal major, a very serious and transfusion requiring process. There are different types of thalassemia--some more concerning than others. Please ask your doctor. ...Read more

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How fatal can thalassemia be?

If taken care of, no: If properly followed and taken care of, treated with transfusions and iron chelation when needed and appropriately followed up, patients with thalassemia have very good life expectancy. ...Read more

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Is there a cure for thalassemia?

Bone marrow trnsplnt: The cure for thalassemia major is through bone marrow transplantation, either from umbilical cord blood stem cells or from donor bone marrow stem cells. Thalassemia minor is a mild form of the disease, so a transplant would not be needed. ...Read more

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Is there any cure for thalassemia?

Transplant for thal: Hematopoietic stem cell transplantation is the cure for severe thalassemia, both Alpha and beta. The best results are when the donor is a brother or sister with a good tissue match to the patient. You can read about treatments on this website: www. Thalassemia. Org. ...Read more

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Does thalassemia alpha shorten life?

Depends: There are four grades of severity of alpha thalassemia. Lack of one or two genes would not affect the life span. Lack of three genes may alter health and life span. Lack of all four genes is generally not compatible with life.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex.
Get HPV vaccine. ...Read more

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How to find match for bmt of thalassemia?

How to find match for bmt of thalassemia?

Cord blood option..: In addition to transplants performed using bone marrow or peripheral blood as the source for stem cells, there has been great progress using cord blood as a source for successful transplants for thalassemia. Cord blood transplants can be a life saver for those who do not have a sibling match, nor a match in the bmt registry. ...Read more

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What type of mutation causes thalassemia?

Hemoglobin: Formation is affected in thalassemia. Mutation in one or both of the genes responsible for the production of hemoglobin proteins (alpha and beta globin) lead to decreased production of these proteins, decreased hemoglobin formation and resulting anemia. ...Read more

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Can full recover the thalassemia patient?

No: But the symptoms can be controlled with proper medical management. Good luck! ...Read more

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What is thalassemia and thalassemia trait?

What is thalassemia and thalassemia trait?

Cooley's Anemia: Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the disorder results in excessive destruction of red blood cells, which leads to anemia. Thalassemia trait is a genetic possibility you pass on to your offspring. The most important reason for discovering if you carry the thalassemia trait is this: if two people who each. ...Read more

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What are the symptoms of beta thalassemia?

What are the symptoms of beta thalassemia?

Anemia: Sever anemia, massive hepatosplenomegaly, sever growth retardation, bony deformities, mongoloid facies. ...Read more

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What should a patient do to reduce thalassemia?

Not sure what u mean: Thalassemia is a constitutional deficiency in the production of one of the globin chains. There are many variants that manifest a wide severity of symptoms from none to transfusion dependence. Alpha thal major (lack of Alpha chain synthesis is incompatible with life. People with thalassemia syndromes need to be evaluated by a hematologist. ...Read more

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What are the signs and symptoms of thalassemia?

What are the signs and symptoms of thalassemia?

None to severe/fatal: Alpha thal: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's (severe) is usually fatal before birth. Beta thal: beta trait has mild anemia; beta intermedia may have weakness, pallor, less growth, and need some transfusions; beta major (cooley's, severe) needs lifelong transfusions. ...Read more

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If someone had beta thalassemia, it is dangerous?

Depends on type...: There are different types of beta thalassemia (minor, intermedia, or major for example) that have much different impacts on a patient's health. Treatment can range from nothing (minor) to requiring frequent blood transfusions, iron chelation therapy or even a bone marrow transplant (major). A hematologist can help with the management of all types. ...Read more

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Are particular people at risk for beta thalassemia?

Yes: Thalassemia is one of the most common gene mutations in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more

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What to do if I have beta thalassemia is this normal?

No: I am going to assume you have beta thalassemia minor. This is a minor abnormality that makes you trivially anemic and makes your blood cells look a little odd. If you marry someone else who has this, each of your children had 1/4 chance of having thal major, which is a horrible illness. Heads up. Best wishes. ...Read more

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My baby's report says he has thalassemia trait. What's that mean?

Knowledge: Thalassemias are autosomal recessive blood disorders. That means you must have two copies of the gene to have the disease. Your baby has one copy of the abnormal gene, so her blood production will be normal. What they need to realize when they grow and get married is if their partner is also a carrier, then their children have a 25% risk of acquiring both genes and developing the disease. ...Read more

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Can I take ginkgo biloba if I have thalassemia? Thanks in advance.

Sure: It's safe. Don't expect miracles but you may find it helpful in feeling better overall. ...Read more

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What is the lifespan for a child have suffering from major thalassemia?

Beta: 20's to 30's: Alpha thalassemia major is fatal before birth in almost all cases. Beta thalassemia major babies look normal at birth. Symptoms start after age 6-8 months. If good treatment starts then, with regular transfusions, plus chelation to remove excess iron, patients can survive into their 20's and 30's. Medical care and technologies improve over time, so that patients today may live longer than before. ...Read more

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What to do if I have beta thalassemia, can I enlist in the national guard?

What kind?: Beta thal minor shouldn't be a problem. If you have beta thal major and are asking this question, you should be congratulated on your excellent response to treatment and I hope that you get what you want -- but don't be disapponted if you're asked to remain a civilian. ...Read more

Dr. Michael Engel
272 Doctors shared insights

Thalassemia (Definition)

An inherited condition ...Read more