Doctor insights on:
Tests For Pseudocholinesterase Deficiency
Because of negative mannitol test & heavy dysnea, Dr. ordered methacholine challenge, but my dna shows pseudocholinesterase deficiency. Safe test?
Methacholine: Did you have PFTs? First do that ,Rrare to use methacholine in the US as those with asthma can have a severe response. Discuss your deficiency and PFTs wtth your doctor. methacholine is metabolized by acethycholinesterase and si resistent to inactivation by pseuodcholinesterase , so that should not be a factor. See http://www.rxlist.com/provocholine-drug/clinical-pharmacology.htm ...Read more
Yes: If you have the genetic problem of prolonged muscle relaxation after the administering of succinylcholine you should display this on a medic alert tag and place it in all of your medical records. It is our hope that someday we will find a replacement medication for this med but we still need it occasionally in anesthetic practice. The diagnosis is made by getting a dibucaine test. ...Read more
Drugs to be aware of: Pseudocholinesterase is a blood plasma enzyme that is responsible for metabolizing certain medications. The most important drug to avoid is succinylcholine --a muscle relaxant used to facilitate intubation. Use of this medication with this deficiency will result in prolonged intubation. Other drugs to avoid are numerous: mivacurium, pilocarpine, huperzine, parathion to name a few. ...Read more
SUX and Medic Alert: if possible, have the bracelet state the actual medical condition or allergy. The most significant issue with this deficiency is the use of succinylcholine (SUX) for intubation of the trachea with a breathing tube. Some individuals have indicated "sux" or "succinylcholine " allergy. ...Read more
Please help! what is the best way for me to put pseudocholinesterase deficiency on a medical alert bracelet?
Tell your anesthesio: Fortunately, this deficiency will rarely cause problems as succinylcholine is hardly ever used. Another drug, called mivacurium, requires an intact pseudocholine esterase system. The most important thing is to tell your anesthesiologist in the event you require surgery. ...Read moreSee 1 more doctor answer
Succinylcholine: - depolarizing muscle relaxant used to facilitate intubation during general anesthesia. It is metabolized by this enzyme and in some people with inborn deficiency, esp. homozygous, administering of this drug (can have different brand names) will lead to prolonged muscle weakness/ paralysis ( hours instead of expected 3-6 minutes). Mivacurium is another one but is rarely used today. ...Read more
No: I have not heard of this association. ...Read more
Not aware : of a direct associtation, without further researching it ...Read more
Should i add my condition pseudocholinehysterase deficiency to my epilepsy medic alert bracelet or is there any need?
Yes: Pseudocholinesterase deficiency is a genetic condition affecting the body's ability to get rid of succinylcholine (sux), a muscle relaxant commonly used during general anesthesia. If you receive sux the muscle paralysis is prolonged requiring a ventilator to assist breathing. Having this info on an alert bracelet is important since in an emergency you may not be able to inform the anesth doctor. ...Read moreSee 2 more doctor answers
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