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Doctor insights on: Tests For Pseudocholinesterase Deficiency

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Because of negative mannitol test & heavy dysnea, Dr. ordered methacholine challenge, but my dna shows pseudocholinesterase deficiency. Safe test?

Because of negative mannitol test & heavy dysnea, Dr. ordered methacholine challenge, but my dna shows pseudocholinesterase deficiency. Safe test?

Methacholine: Did you have PFTs? First do that ,Rrare to use methacholine in the US as those with asthma can have a severe response. Discuss your deficiency and PFTs wtth your doctor. methacholine is metabolized by acethycholinesterase and si resistent to inactivation by pseuodcholinesterase , so that should not be a factor. See http://www.rxlist.com/provocholine-drug/clinical-pharmacology.htm ...Read more

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Please help! what is the best way for me to put pseudocholinesterase deficiency on a medical alert bracelet?

Please help! what is the best way for me to put pseudocholinesterase deficiency on a medical alert bracelet?

Tell your anesthesio: Fortunately, this deficiency will rarely cause problems as succinylcholine is hardly ever used. Another drug, called mivacurium, requires an intact pseudocholine esterase system. The most important thing is to tell your anesthesiologist in the event you require surgery. ...Read more

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What is a good way for me to put pseudocholinesterase deficiency on a medical alert bracelet?

What is a good way for me to put pseudocholinesterase deficiency on a medical alert bracelet?

SUX and Medic Alert: if possible, have the bracelet state the actual medical condition or allergy. The most significant issue with this deficiency is the use of succinylcholine (SUX) for intubation of the trachea with a breathing tube. Some individuals have indicated "sux" or "succinylcholine " allergy. ...Read more

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Should I put pseudocholinesterase deficiency on a medical alert bracelet?

Should I put pseudocholinesterase deficiency on a medical alert bracelet?

Yes: If you have the genetic problem of prolonged muscle relaxation after the administering of succinylcholine you should display this on a medic alert tag and place it in all of your medical records. It is our hope that someday we will find a replacement medication for this med but we still need it occasionally in anesthetic practice. The diagnosis is made by getting a dibucaine test. ...Read more

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Expert opinions? Which drugs should be avoided in pseudocholinesterase deficiency?

Expert opinions? Which drugs should be avoided in pseudocholinesterase deficiency?

Drugs to be aware of: Pseudocholinesterase is a blood plasma enzyme that is responsible for metabolizing certain medications. The most important drug to avoid is succinylcholine --a muscle relaxant used to facilitate intubation. Use of this medication with this deficiency will result in prolonged intubation. Other drugs to avoid are numerous: mivacurium, pilocarpine, huperzine, parathion to name a few. ...Read more

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Which drugs should be avoided by patients with pseudocholinesterase deficiency?

Which drugs should be avoided by patients with pseudocholinesterase deficiency?

Succinylcholine: - depolarizing muscle relaxant used to facilitate intubation during general anesthesia. It is metabolized by this enzyme and in some people with inborn deficiency, esp. homozygous, administering of this drug (can have different brand names) will lead to prolonged muscle weakness/ paralysis ( hours instead of expected 3-6 minutes). Mivacurium is another one but is rarely used today. ...Read more

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Should i add my condition pseudocholinehysterase deficiency to my epilepsy medic alert bracelet or is there any need?

Should i add my condition pseudocholinehysterase deficiency to my epilepsy medic alert bracelet or is there any need?

Yes: Pseudocholinesterase deficiency is a genetic condition affecting the body's ability to get rid of succinylcholine (sux), a muscle relaxant commonly used during general anesthesia. If you receive sux the muscle paralysis is prolonged requiring a ventilator to assist breathing. Having this info on an alert bracelet is important since in an emergency you may not be able to inform the anesth doctor. ...Read more

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What are the tests for IgA deficiency?

What are the tests for IgA deficiency?

Blood test: To determine if you have an IgA deficiency, a simple blood test can be done. ...Read more