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Doctor insights on: Tests For Liver Fibrosis

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Dr. Shari Jackson
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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How could a liver function test detect chronic liver disease?

How could a liver function test detect chronic liver disease?

Elevations: Elevated Liver function tests may occur for a variety of issues from Fatty infiltration (hepatic steatosis), viral illnesses such as the hepatitis viruses, Alcoholism, increased use of medications that metabolize through the liver (such as Acetaminophen), cirrhosis, biliary disease, tumors, gallbladder disease, etc, etc. Get an evaluation for the most likely cause if you feel you have liver Dx. ...Read more

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What are the tests for hepatic fibrosis?

What are the tests for hepatic fibrosis?

HepaScore: If not liver biopsy, alpha2 macro globulin increase; a lipoprotein a1 decrease, ggt, bilirubin, hyaluronic enzyme immunoassay; sex and age factor in as well. ...Read more

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What are the tests for chronic liver disease?

What are the tests for chronic liver disease?

1: Multiple blood tests to determine cause like hepatitis c, alcohol, iron overload etc., ultrasound and ct scan of liver and gold standard is liver biopsy. ...Read more

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What are the tests for pulmonary fibrosis?

What are the tests for pulmonary fibrosis?

Several: A high resolution ct scan of the thorax can give valuable information. Blood tests looking for underlying autoimmune diseases are usually done. Many times a lung biopsy may be required for accurate diagnosis. ...Read more

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What are the tests for biliary cirrhosis?

What are the tests for biliary cirrhosis?

Autoantibody &Biopsy: In addition to abnormal blood tests due to malfunction of liver, patients with primary biliary cirrhosis have peculiar autoantibodies, anti-mitochondrial antibodies. Blood tests and imaging suggest cirrhosis, confirmation requires biopsy (usually needle biopsy) and examination of the tissue by a pathologist. ...Read more

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Could liver function tests reveal autoimmune hepatitis?

Could liver function tests reveal autoimmune hepatitis?

Yes: Liver function tests are often elevated in autoimmune hepatitis. This is a non- specific test. If the liver function tests are elevated additional diagnostic tests will be necessary. The anti smooth muscle antibody is one of the most important in pointing to this diagnosis. Tests for other liver diseases such as hepatitis and primary biliary cirrhosis are usually part of the evaluation. ...Read more

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What are the tests for bilary cirrhosis?

What are the tests for bilary cirrhosis?

Autoantibody &: Biopsy. In addition to abnormal blood tests due to malfunction of liver, patients with primary biliary cirrhosis have peculiar autoantibodies, anti-mitochondrial antibodies. Blood tests and imaging suggest cirrhosis, confirmation requires biopsy (usually needle biopsy) and examination of the tissue by a pathologist. ...Read more

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Can liver fibrosis due to drinking be reversed?also does acute liver failure cause long term damage over time as it heals?biopsy revealed fibrosis.

Can liver fibrosis due to drinking be reversed?also does acute liver failure cause long term damage over time as it heals?biopsy revealed fibrosis.

Not likely : Fibrosis of the liver is staged as 1-4. Stage 4 is cirrhosis. The problem with fibrosis is that it represents scar tissue formed within your liver due to repetitive damage to the hepatocytes (liver cells). Fibrosis may not be diagnosed after several years of repetitive acute damage. Review your pathology report and see what stage of fibrosis you are: early (1-2) or late (3-4). ...Read more

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What are liver function test results if hepatitis?

What are liver function test results if hepatitis?

Hepatitis which?: Your question does not make any sence.There are different hepatitis, a, b, c.Non abc liver functiobn test only tell us if there is elevation of liver enzymes indicating for more tests tests are sgot, SGPT and alkaline phosphatase. ...Read more

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What urine tests are needed for chronic kidney disease?

What urine tests are needed for chronic kidney disease?

Depends on the type : Of disease. Measurement of serum creatinine is a good test to assess the degree of kidney disease. Other tests may be chosen depending on the cause of chronic kidney disease, e.G, urinalysis, serum protein electrophoresis, autoantibodies etc. ...Read more

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What are the tests for idiopathic pulmonary fibrosis?

What are the tests for idiopathic pulmonary fibrosis?

CT or biopsy: The "gold standard" test for idiopathic pulmonary fibrosis is a lung biopsy, usually via lung surgery. But, nowadays, ct scan has gotten very good at diagnosing ipf, and sometimes this is enough. But, usually, lung biopsy is required to make a diagnosis. ...Read more

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Can a liver biopsy miss cirrhosis or alcohol liver disease?? Mine showed no fibrosis but mild steatosis

Unlikely: Cirrhosis affects the whole liver and a biopsy is unlikely to miss the lesion. Steatosis is one manifestation of alcoholic liver disease. If there is any concern about liver disease, you should not use alcohol, or Tylenol (acetaminophen). If you are overweight, lose weight. Take vaccination for hepatitis A and B. ...Read more

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What are some reasons behind elevated liver enzymes? Tested negative for hepatitis and diabetes. Going for a liver scan soon. Possible outcomes?

What are some reasons behind elevated liver enzymes? Tested negative for hepatitis and diabetes. Going for a liver scan soon. Possible outcomes?

Fatty Liver: Liver is the main organ that gets all of the blood supply to remove nutrients and also process unwanted food and send it via bowels or kidney. If there is elevation and no evidence of infection or autoimmunity it may be and fatty liver which comes from our modern diet of processed foods and sugary diet. ...Read more

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Would blood tests for gloucose and thyroid reveal liver ussues?

Would blood tests for gloucose and thyroid reveal liver ussues?

No: There are specific tests for liver function and those are different from glucose and thyroid function tests. ...Read more

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QUESTION FOR HEPATOLOGISTS: Could two Fibroscans and 3 ultrasounds miss advanced liver cirrhosis? Biopsy is out of the question

QUESTION FOR HEPATOLOGISTS: Could two Fibroscans and 3 ultrasounds miss advanced liver cirrhosis? Biopsy is out of the question

Reasonable test: If biopsy if unreasonable, the a fibroscan is a reasonable alternative. It is quite specific, meaning that if you are low value/result that it's unlikely that you have advanced fibrosis/cirrhosis, the actual percentage or specificity value, depends on your cut off point. So if you provide your specific results docs here may be better able to guide you. ...Read more

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What types of cirrhosis can a liver biopsy and fibroscan miss?

What types of cirrhosis can a liver biopsy and fibroscan miss?

You are okay man!: A Biosy that is adequate and that does not show cirrhosis rules out cirrhosis and our question is how to help a thoughtful guy like yourself to be comfortable. A second pathologist reading is available if you wish, or a consult with a specialist in emotions. ...Read more

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What is a meld test for liver transplant?

What is a meld test for liver transplant?

Prioritizes patients: Meld (model for end-stage liver disease) score allows for an estimation of life expectancy for people with end stage liver disease.There are more people needing transplants than there are donor livers; those determined by meld score to be highest risk of dying over the next 3 months are placed higher on the list.Meld is calculated from blood test results (bilirubin, creatinine, inr). ...Read more

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Best serum tests for liver damage (fibrosis/cirr.)? Ggt, apo a1, a2 alpha gammaglobulin, ldh, haptoglobin? Others? How to interpret? Caff breath test?

Best serum tests for liver damage (fibrosis/cirr.)? Ggt, apo a1, a2 alpha gammaglobulin, ldh, haptoglobin? Others? How to interpret? Caff breath test?

Need more tests: Serum tests may never become abnormal from fibrotic or cirrhosis until late. Ultrasound abdomen is good. Ct may help. Liver biopsy is best. Usually clinical history helps. Nonalcoholic fatty liver is emerging as a new and potentially big problem and is mostly diagnosed incidentally on ct or ultrasound of abdomen. ...Read more

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What cab be done for interstitial lung disease and pulmonary fibrosis?

What cab be done for  interstitial lung disease and pulmonary fibrosis?

Not much: Ild/pulm fibrosis is a progressive destruction of lung architecture resulting in progressive shortness of breath. All therapy tried to date has not provided much improvement. Oxygen and exercise while awaiting lung transplant is a current management option. The mortality of ipf is on the order of less than 5 yr after dx. ...Read more

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Best serum tests for liver damage (fibrosis/cirr.)? Ggt, apo a1, a2 alpha gammaglobulin, ldh, haptoglobin? Others? How to interpret? Caff breath test?

Need more tests: Serum tests may never become abnormal from fibrotic or cirrhosis until late. Ultrasound abdomen is good. Ct may help. Liver biopsy is best. Usually clinical history helps. Nonalcoholic fatty liver is emerging as a new and potentially big problem and is mostly diagnosed incidentally on ct or ultrasound of abdomen. ...Read more

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What test can rule out liver fibrosis?

What test can rule out liver fibrosis?

Many tests: The most definitive, or the gold standard is the Liver biopsy, which involves minor surgery. There are other non-invasive blood tests of liver function and ultrasound test. ...Read more

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What is advanced liver fibrosis?

What is advanced liver fibrosis?

Cirrhosis: Another term will be cirrhosis or replacement of normal tissue by scar tissue. ...Read more

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I need answers to liver fibrosis issues?

I need answers to liver fibrosis issues?

OK: what questions do you have? What caused the liver fibrosis? Oftentimes, it's irreversible. Continued injury to the liver can result in cirrhosis. ...Read more

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Is liver fibrosis reversible/fatal? Thank you

Is liver fibrosis reversible/fatal?  Thank you

Liver fibrosis: In general, liver fibrosis is not reversible. It is one step in the liver's response to injury, and progresses to become more widespread ("bridging") before the liver tries to regenerate, forming nodules, and at that time, cirrhosis is diagnosed. However, some insults if caught early may arrest or slow the progression of liver fibrosis. For instance, non alcoholic fatty liver disease can improve. ...Read more

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How much time does it take liver fibrosis to go to cirrhosis?

How much time does it take liver fibrosis to go to cirrhosis?

Depends on degree: of fibrosis - but most causes of fibrosis (hepatitis) take 30-40 years to develop into cirrhosis. less time if multiple factors are at play (viral hepatitis AND alcohol, for example) ...Read more

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How do I know if I have liver fibrosis? (I'm getting an ultrasound but I'd like to know the symptoms of it)

How do I know if I have liver fibrosis? (I'm getting an ultrasound but I'd like to know the symptoms of it)

Symptoms are: highly variable and depend on the severity of the fibrosis. If mild, there may be no symptoms. If severe, there may be advanced liver failure. ...Read more

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Can liver fibrosis be measured in patients with hiv/aids?

Can liver fibrosis be measured in patients with hiv/aids?

Probably: Hiv/aids by it self is not a main cause of liver damage; however there are patients who are co-infected with hepatitis c, which in turn can cause liver injury, an ultrasound of the liver may indicate fibrosis but a biopsy can confirm the diagnosis; certain medications against hiv/aids may also cause liver damages ( niverapine). ...Read more

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Can birth control pills cause liver fibrosis?

Can birth control pills cause liver fibrosis?

Possible: There has been some association between long term use of birth control and liver tumors found recently. Talk with you gym and primary care about this. ...Read more

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Can liver fibrosis due to drinking be reversed?also does acute liver failure cause long term damage over time as it heals?biopsy revealed fibrosis.

Not likely : Fibrosis of the liver is staged as 1-4. Stage 4 is cirrhosis. The problem with fibrosis is that it represents scar tissue formed within your liver due to repetitive damage to the hepatocytes (liver cells). Fibrosis may not be diagnosed after several years of repetitive acute damage. Review your pathology report and see what stage of fibrosis you are: early (1-2) or late (3-4). ...Read more

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Husband has liver fibrosis bridging cirrhosis but stopped drinking. takes lactulose and stopped drinking three months ago.will disesase get better?

Husband has liver fibrosis bridging cirrhosis but stopped drinking. takes lactulose and stopped drinking three months ago.will disesase get better?

Hoping so!: I'm going to assume that alcohol is the sole cause, and that he's been checked for hemochromatosis, Wilson's, and hepatitis B and C. If he does choose to stop drinking, having a loving and forgiving wife will be the most wonderful support he can have. Cirrhosis does regress some on achieving sobriety. Hopefully his mind is still basically okay. Wishing you both the best. ...Read more

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Would an ultrasound show liver fibrosis or cirrhosis? does an enlarged liver (16.7cm length) with significant fatty infiltration mean cirrosis started

Would an ultrasound show liver fibrosis or cirrhosis? does an enlarged liver (16.7cm length) with significant fatty infiltration mean cirrosis started

Fatty infiltration: is a relatively common finding, is due to a number of various causes(sometimes there is no known cause), and is not necessarily a precursor to cirrhosis. Ultrasound can detect changes of cirrhosis, although it is not necessarily specific(other infiltrative processes might lok similar) unless there are advanced secondary signs, and biopsy or additional imaging(MRI) might be needed. ...Read more

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I was diagnosed with liver sarcoidosis. mri stated I have liver fibrosis and scarring. been have painful dull aching pain on my right side of my stom?

I was diagnosed with liver sarcoidosis.  mri stated I have liver fibrosis and scarring. been have painful dull aching pain on my right side of my stom?

Sarcoidosis: This rather complicated situation is best managed by a collaboration between a liver specialist(hepatologist, gastroenterologist) and a rheumatologist or infectious disease specialist. I would want to be clear as to the actual cause of your abdominal discomfort and whether treatment for the sarcoidosis is indicated at this time. Both specialists would provide follow-up care. ...Read more

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Would normal liver ultrasound result and fibroscan result of 5.5 kpa/CAP 227, be enough to exclude liver fibrosis? Mild raised ggt. All other normal

Mild or no fibrosis: First of all, using FibroScan® to obtain a reliable liver stiffness measurement may require 10 or more valid measurements, according to the manufacturer's recommendations. The range of kPa values for normal and patients with fibrosis do overlap, but a value of 5.5 is low enough to exclude the need for biopsy as no or mild fibrosis. It does not rule out liver disease. Repeat study in a year ...Read more

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Alcohol caused husbands liver fibrosis. ammonia levels are slightly elevated and he takes lactulose. does fibrosis cause this when it's not cirrhosis?

Alcohol caused husbands liver fibrosis. ammonia levels are slightly elevated and he takes lactulose. does fibrosis cause this when it's not cirrhosis?

Increased ammonia: By the time someone with alcoholic liver disease develops hepatic encephalopathy, cirrhosis of the liver is usually present. If the elevation is only slight and he is asymptomatic, it is possible to have fibrosis without cirrhosis, but he is certainly on his way to it. It is very important not to drink anymore alcohol at all. He also should not drive. He should follow up closely with his doctor. ...Read more

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Liver Dr's-Is it JUST fibrosis that can be assessed/likely diagnosed from the serum marker tests like ELF, or other disease also? Thanks

Liver Dr's-Is it JUST fibrosis that can be assessed/likely diagnosed from the serum marker tests like ELF, or other disease also? Thanks

Fibrosis/cirrhosis: Although the most accurate way to assess fibrosis or cirrhosis is with liver biopsy (LB), it is invasive and therefore not used routinely. Three non-invasive tests are now used to assess scarring, two blood tests FibroTest and Enhanced Liver Fibrosis (ELF), as well as a scan, FibroScan or transient elastography (TE). The accuracy compared to LB is less, more accurate for cirrhosis than fibrosis ...Read more

Dr. ASHRAF MALEK
25 doctors shared insights

Liver Scarring (Definition)

Liver scarring = Fibrosis of liver cells. Cirrhosis occurs when the is scar tissue built- ...Read more