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Doctor insights on: Terminal Ileum Biopsy

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Dr. Steven Griggs
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


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Terminal ileum biopsy- ileum type mucosa with prominent lymphoid aggregate. What does this mean.

Normal biopsy: The ileum normally has numerous lymphoid aggregates. To a pathologist, this actually helps us figure out which part of the small intestine the biopsy is from. Unless something else was stated in your report, this should be taken as "normal." ...Read more

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Terminal ileum biopsy: unremarkable ileal mucosa. Negative for active/ chronic ileitis, no granulomas seen. Meaning? Good? Bad? Thanks

Sampling: It is good that there was no pathology in the tissue biopsied. Please keep in mind that the pathologist can only tell you what was in the tissue that was removed, not what is the rest of the body. Lesions in Crohns can be patchy and you need to follow your doctor's advice about follow-up care. ...Read more

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My Bf had colonoscopy done & diagnosed with apthoid ulcer measuring 1 mm in terminal ileum.biopsies were obtained,reports says cannot identify problem?

My Bf had colonoscopy done & diagnosed with apthoid ulcer measuring 1 mm in terminal ileum.biopsies were obtained,reports says cannot identify problem?

Small bowel ulcer: Could be anything from as simple as an isolated ulcer from aspirin or anti-inflammatory medication induced to the early signs of Crohn's disease ...Read more

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Hey Recently my Bf had his colonoscopy done and it was identified that three apthoid ulcer were found measuring 1 mm in the terminal ileum. biopsies were obtained but the biopsies reports says that they cannot identify the problem. do i need to worry ?

Ileum ulcers: In general, you should not have to worry. Aphthous ulcers in the ileum can have many underlying causes, including infection, autoimmune, medication (pills usually) and idiopathic (inflammatory bowel disease.) Depending on the symptoms that led to the colonoscopy, further work-up or trial therapies may lead to more specific answers. Cancer not likely on the list at his age. ...Read more

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Hey Recently my Bf had his colonoscopy done and it was identified that three apthoid ulcer were found measuring 1 mm in the terminal ileum. biopsies were obtained but the biopsies reports says that they cannot identify the problem. do i need to worry ?

Misinformed: You need to discuss with your physician the exact contents of the biopsy report. It is unlikely that the pathologist would simply say can't identify the problem; more likely it offers several possibilities or differential diagnosis for your physician to work on ...Read more

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Colonoscopy -small ulcers in the terminal ileum. Biopsy confirms focal ileitis with superficial erosion, but no specific cause identified. What next?

Colonoscopy -small ulcers in the terminal ileum. Biopsy confirms focal ileitis with superficial erosion, but no specific cause identified. What next?

Consult GI: Most common causes are crohn's disease and ulcerative colitis. There are several medications which can be helpful besides diet (gluten free). You should discuss these with the gastroenterologist.If not satisfied, you can always get a second opinion. ...Read more

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Small ulcer in terminal ileum, biopsy: In Eosinophil fokal chronic active ileites, lymphoid hyperplasia. non specific colitis. Crohn ruled out. any suggest?

Yes: Call up the G.I. doctor that did the test he can give you more specific information about diagnosis and treatment for your condition ...Read more

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Doc. Found ulcer in terminal ileum, did biopsy, said biopsy shows inflammation..Now wants to do barium X-ray of small bowel. Why? What's he lookin 4?

Doc. Found ulcer in terminal ileum, did biopsy, said biopsy shows inflammation..Now wants to do barium X-ray of small bowel. Why? What's he lookin 4?

He's looking for...: Crohn's, behcet's, infection, nsaid-related injury, etc. The small bowel imaging (ct enterography, mr enterography, small bowel follow-through) can help determine what other parts of the intestine may be affected ; the extent of that disease (if present), as clues to the diagnosis. ...Read more

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Will capsule endoscopy identify cause of ulcers in terminal ileum seen in colonoscopy. Biopsy confirmed focal ileitis with superficial erosion?

Will capsule endoscopy identify cause of ulcers in terminal ileum seen in colonoscopy. Biopsy confirmed focal ileitis with superficial erosion?

Capsule endoscopy is: For small bowel evaluation where upper or lower endoscopy can't reach. It may give you information regarding the rest of small bowel. Its usually done to look for small bowel lesions or to find the source of a bleed where egd/colonoscopy is negative. In your case the better test is mr enetrography or a ct abd/pel with volumen contrast. Your GI doc should decide on further testing. ...Read more

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I had a colonoscopy last week, which came back clear, however on my report it shows that 40 biopsies were taken from the rectum to the terminal ileum?

I had a colonoscopy last week, which came back clear, however on my report it shows that 40 biopsies were taken from the rectum to the terminal ileum?

Depends: Why was the colonoscopy done? If it was as monitoring for inflammatory bowel disease, then the biopsies were appropriate. Give it a week or so and check with your doctor about the results of the biopsies.
Wish you good health and a Happy New Year! ...Read more

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Pls help? Biopsies from the terminal ileum show chronic inflammation with prominent lymphoid follicles to be reactive in nature .

Pls help? Biopsies from the terminal ileum show chronic inflammation with prominent lymphoid follicles  to be reactive in nature .

Terminal ileum biops: Your pathology of the terminal ileum is benign. This does not mean that you are having crohn's disease. However, discuss this with your GI physician for other questions and possible treatment for your symptoms. You must have a colonoscopy for a reason. ...Read more

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Biopsy from terminal ileum during colonoscopy showed "focal ileitis with superficial erosion. No granulomas, no specific cause identified" ?

Biopsy from terminal ileum during colonoscopy showed "focal ileitis with superficial erosion. No granulomas, no specific cause identified" ?

Forerunner: Of worse to come unless the dietary cause is eliminated. I have always stopped my patients from taking milk and milk products when they have ulcerative colitis. Try it! its cheap. Also check out your diet in general. Apart from milk, restrict it to "god made" foods. ...Read more

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The doctor biopsied my terminal ileum because there was a patchy area of mucosa that was mildly granular. Could this be serious?

Yes: He/she is probably being careful and looking for a diagnosis. Early Crohn's can look like this, and there are other entities. The pathologist may or may not be able to call it. ...Read more

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colonoscopy results says ileitis biopsy says benign terminal ileum with prominent payer patches CD3 t cells and CD20 b cells positive is it crohns

colonoscopy results says ileitis biopsy says benign terminal ileum with prominent payer patches CD3 t cells and CD20 b cells positive is it crohns

Clinical picture: The colonoscopy and biopsy results need to be correlated with the clinical symptoms and signs to make a definite diagnosis. They should not be taken in isolation. ...Read more

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Colonoscopy ok except terminal ileum tiny ulcer with surrounding nodularity. Multiple biopsy taken.Diagn:nonspecific superficial ulcer with inflammation. Pain in the umbilical. Freq.Dysentery slime?

Colonoscopy ok except terminal ileum tiny ulcer with surrounding nodularity. Multiple biopsy taken.Diagn:nonspecific superficial ulcer with inflammation.  Pain in the umbilical.  Freq.Dysentery slime?

Check small bowel: Aside from checking for infections, parasites, etc. Would make sure rest of small bowel is ok. Make sure no celiac sprue (screen with blood tests), or crohn's diseade ( various radiology tests and/or capsule endoscopy-evaluation may depend on insurance). ...Read more

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What does increase cellularity of lamina propria w eosin, lymphoid nod, and paneth cell metaplasia mean in colonic biopsy of terminal ileum?

What does increase cellularity of lamina propria w eosin, lymphoid nod, and paneth cell metaplasia mean in colonic biopsy of terminal ileum?

Chronic inflammation: Paneth cell metaplasia occurs when the bowel mucosa undergoes chronic inflammatory damage and then regenerates. The findings are commonly seen in association with inflammatory bowel disease (ulcerative colitis or crohn's). ...Read more

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Ct scan shows mild thickening of terminal ileum, appears chronic in nature, no inflammation. What could cause this? Biopsy ruled-out Crohn's and uc.

Ct scan shows mild thickening of terminal ileum, appears chronic in nature, no inflammation. What could cause this? Biopsy ruled-out Crohn's and uc.

IBD: If the biopsy is negative and currently there are no symptoms., i will ignore it for the time being. It may represent healing following some inflammatory process. I would just follow it up with your doctor .If it remains unchanged or getting worse repeat biopsy should be considered. ...Read more

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Does IBS cause inflammation in colon on cecum and ileum confirmed by biopsy?

Does IBS cause inflammation in colon on cecum and ileum confirmed by biopsy?

No: ? whether IBS has associated tissue biopsy changes. Not usually, the peristaltic hypermotility of IBS is not organic, but is functional and likely caused by dysautonomia of the autonomic nervous system. Tissue biopsy changes are often seen with IBD, irritable bowel disorder, such as with Crohn's Disease or Ulcerative Colitis. ...Read more

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Hi, my colonoscopy result 1. Mucosal biopsy from ileum shows hypertrophied lymphoid follicles. I have a vague discomfort in the lower right abdomen. I am afraid. Should I be worried?

Not from this: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, what you described of the biopsy is a non-specific finding and not diagnostic of any thing.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Biopsy confirmed inflammation on cecum and ileum but Prometheus panel neg for crohns and UC. Stool neg for infec. Only take synthroid (thyroxine). Cause?

Crohn's: Crohn's is still not off the list, a Prometheus is not a definitive , be all end all test. Rarely does the biopsy come back saying this is absolutely Crohn's. You need to input of a good GI doc.There are other test such as a fecal calprotectin . ...Read more

Ileum (Definition)

The last (furthest from the mouth) of three parts of the small intestine. It is involved primarily in absorption of various nutrients that have been digested in the stomach and earlier portions ...Read more


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