Doctor insights on:
Taxol And Receptin
Biologic Therapy: Herceptin/trastuzumab is an antibody to a cell surface proteint coded for by the her2neu gene. Its present in some normal cells but in a subset of breast cancers (10-15%) there are multiple copies of the gene producing large amounts of the protein. The herceptin/trastuzumab antibody binds to that protein and reduces that aggressive nature of her2+cancer. It is usually given with chemo. ...Read moreSee 2 more doctor answers
Chemotoxicity: ABRAXANE is an Injectable suspension of paclitaxel , a derivative of Taxol formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nanometers and sodium acetyltryptophanate . Toxicity of taxol and abraxane are similar and present with numbness, tingling, pain, or weakness in hands or feet; Sudden chest pain or discomfort, wheezing dry cough, Low WBC and fever. ...Read more
Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?
Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read moreSee 1 more doctor answer
NO: Faslodex (fulvestrant) is an anti estogen therapy -used to treat hormone receptor positive breast cancer (breast cancer that depends on hormones such as estrogen to grow)- is given by injecting medication into the muscle. Xeloda is an oral chemotherapy- which is a pro drug of 5fu. It is used to treat different kind of cancer such as- colon, esophagus, rectal, breast . They are not similar. ...Read more
Heart failure: About 4% of women treated with Herceptin (trastuzumab) develop some weakness in their heart as measured by a muga test. This decrease in heart function is reversible when the drug is stopped. Other side effects of Herceptin (trastuzumab) can include allergic reaction, fatigue, headache and diarrhea. Most of my patients have no side effects! ...Read moreSee 1 more doctor answer
What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?
Treatment options: For stage IV breast cancer- if the cancer progressed after tamoxifen and aromasin- depending on several factors such as how much cancer burder, involvement to visceral organs, overall condition etc- the options would be- faslodex; combination of Aromasin (exemestane) and evorilimus ( based on recent randomized clinical trial) or chemotherapy. Discuss further with your oncologist- which one for your case. ...Read moreSee 1 more doctor answer
Restate question: Hi jsalyers9. Can you restate your question with a little more information. What is being treated? What treatments have already occurred? Thanks. ...Read more
Less neuropathy: Unlike taxol, (paclitaxel) gemcitabine does not cause neuropathy. It can cause low platelets. It can also cause fluid retention. Also it is usually given 2 weeks on and 1 week off. Unlike Taxol (paclitaxel) which typically is given weekly. That is about it in regards to the difference. Hope this helps. ...Read moreSee 1 more doctor answer
Not really: Abraxane is a derivative of Taxol. It is employed after recurrent or metastatic pancreas cancers have failed Gemzar (gemcitabine) adding about 8 wks to the overall survival in these patients. The drug,protein-bound paclitaxel is an injectable formulation of paclitaxel, It has almost the same extent of neuropathy. ...Read more
Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read moreSee 1 more doctor answer
Killing cancer cells: Herceptin (trastuzumab) is an antibody, which is the y-shaped green thing in the picture. It sticks to the her2 protein which is present on some breast cancers (and other cancers). Herceptin (trastuzumab) seems to help the body's immune cells "see" and attack the cancer cells. For women with her2 positive breast cancer, it decreases the risk of the cancer returning by almost 50%! ...Read moreSee 1 more doctor answer
Several: Herceptin (trastuzumab) is remarkably well tolerated. The most common side effect is a decline in the pumping ability of the heart (called the left ventricular ejection fraction), possibly leading to congestive heart failure. Thus, people getting Herceptin (trastuzumab) should have an echocardiogram done before, and about every 3 months while on herceptin (trastuzumab). Most of the time, the heart recovers after the Herceptin (trastuzumab) is stopped. ...Read moreSee 1 more doctor answer