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Doctor insights on: Taxol And Avastin

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Can Abraxane and Avastin (bevacizumab) be used for treating ovarian cancer?

Can Abraxane and Avastin (bevacizumab) be used for treating ovarian cancer?

Yes it is an option: The standard therapy for ovarian cancer initially is still a taxane (usually Taxol) and Carboplatin. However, Abraxane is an effective taxane down the line for recurrences, and is potentially less toxic. Avastin (bevacizumab) has been combined safely with Abraxane and the two may be helpful for recurrence management. But the question is a bit difficult to answer concretely because circumstances differ. ...Read more

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Is Abraxane or Taxol (paclitaxel) better for neuropathy?

Is Abraxane or Taxol (paclitaxel) better for neuropathy?

Not really: Abraxane is a derivative of Taxol. It is employed after recurrent or metastatic pancreas cancers have failed Gemzar (gemcitabine) adding about 8 wks to the overall survival in these patients. The drug,protein-bound paclitaxel is an injectable formulation of paclitaxel, It has almost the same extent of neuropathy. ...Read more

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What are the different side effects of Abraxane and Taxol (paclitaxel)?

What are the different side effects of Abraxane and Taxol (paclitaxel)?

Chemotoxicity: ABRAXANE is an Injectable suspension of paclitaxel , a derivative of Taxol formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nanometers and sodium acetyltryptophanate . Toxicity of taxol and abraxane are similar and present with numbness, tingling, pain, or weakness in hands or feet; Sudden chest pain or discomfort, wheezing dry cough, Low WBC and fever. ...Read more

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What are trastuzumab and herceptin?

What are trastuzumab and herceptin?

Biologic Therapy: Herceptin/trastuzumab is an antibody to a cell surface proteint coded for by the her2neu gene. Its present in some normal cells but in a subset of breast cancers (10-15%) there are multiple copies of the gene producing large amounts of the protein. The herceptin/trastuzumab antibody binds to that protein and reduces that aggressive nature of her2+cancer. It is usually given with chemo. ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard(old/conventional treatments). If the new treatment if better(more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more

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What are the side effects of Xeloda (capecitabine) and neotherapy for cancer?

What are the side effects of Xeloda (capecitabine) and neotherapy for cancer?

Xeloda (capecitabine): http://www.nlm.nih.gov/medlineplus/druginfo/meds/a699003.html if any concern, please see your oncologist and discuss further with your md. ...Read more

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How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

See below: It is not a curall for colon cancer but is effective therapy to a large extent it depends onthe size and wehre it is. Almost certianly it requires more than this drug to get a cure if acure is possible. ...Read more

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What is the role of Taxol (paclitaxel) in chemotherapy?

What is the role of Taxol (paclitaxel) in chemotherapy?

Kills cancer cells!: Taxol (paclitaxel) works by preventing cancer cells from reproducing themselves. In the picture you can see green "microtubules" that are pulling a cancer cell apart into two daughter cells. Taxol blocks microtubules, preventing them from being able to pull the cancer cell into two daughter cells. The cancer cell gets stuck trying to divide, and it dies. Taxol works for many cancer types. ...Read more

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Which is more effective: Avastin (bevacizumab) or Erbitux?

Which is more effective: Avastin (bevacizumab)  or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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Are the cancer drugs, gefitinib and tarceva (erlotinib) available?

Are the cancer drugs, gefitinib and tarceva (erlotinib) available?

While gefitinib was: Developed first, it is hard to find in america (iressa (gefitinib)). Erlotinib (tarceva) has more side effects, but a trial showed a survival advantage. Probably more related to the characteristics of the study participants than the drug. These are small molecule, tyrosine kinase inhibitors in the erb family of receptors. Canada and europe has iressa (gefitinib). Erlotinib is in us. ...Read more

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Are faslodex (fulvestrant) and Xeloda similiar to each other?

Are  faslodex (fulvestrant) and Xeloda similiar to each other?

NO: Faslodex (fulvestrant) is an anti estogen therapy -used to treat hormone receptor positive breast cancer (breast cancer that depends on hormones such as estrogen to grow)- is given by injecting medication into the muscle. Xeloda is an oral chemotherapy- which is a pro drug of 5fu. It is used to treat different kind of cancer such as- colon, esophagus, rectal, breast . They are not similar. ...Read more

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What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?

What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?

Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more

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For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read more

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How can Taxol (paclitaxel) against the cancer?

How can Taxol (paclitaxel) against the cancer?

Unclear question: Please tell us in more detail: what do you want to know about taxol (paclitaxel)? It is a chemotherapy drug which is very useful in treating several different cancers. ...Read more

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Does Taxol (paclitaxel) stabilize microtubules?

Taxol (paclitaxel): Yes. You can read about this "Insights into the mechanism of microtubule stabilization by Taxol" See: http://www.pnas.org/content/103/27/10166.full ...Read more

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Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Chemotherapy for SS: I would potentially seek out an opinion from the mayo clinic oncology department who are not very far north of you. I can help set that up for you. Please contact me at David.stockman@orthopath.com ...Read more

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Can gemcitabine be substituted for taxotere (docetaxel)?

Can gemcitabine be substituted for taxotere (docetaxel)?

Gem for taxotere (docetaxel): Short answer is no. It cannot be substituted. Now depending upon the underlying cancer whether lung, breast, pancreatic or any other primary solid tumor, one can use taxol, Abraxane or Navelbine (vinorelbine) (they are taxanes like taxotere). If we want to move to a different agent altogether, then Gemzar or a no of other drugs would be available depending upon what the primary tumor is. ...Read more