Doctor insights on:
Tasigna Vs Sprycel
What makes Trovax different from other kidney cancer meds (like nexavar, proleukin, torisel, (temsirolimus) sutent)?
Other drugs worked: Nexavar, torisel, and sutent all received FDA approval because they improved progression free survival. The initial Trovax trial was terminated early because there was little or no prospect of demonstrating a statistically significant survival benefit compared to placebo. http://clincancerres.aacrjournals.org/content/16/22/5539.long ...Read moreSee 1 more doctor answer
Besides p6 protocol from mskcc, or clinical trials vs tki like pazopanib/sunitinib- other good regimen for st IV desmoplastic small round cell tumor?
No: There is no good therapy for this condition. I refer patient's in my practice with this condition to mskcc because i believe that their transitional research program may lead to discoveries that change the poor natural history of this cancer. Surgical debulking, radiation therapy, experimental chemotherapy including stem cell rescue are all under study; none are standard of care. ...Read moreSee 1 more doctor answer
Peripheral t-cell lymphoma cure: chop induction+ifosfamide/mtx + autologous transplant or romidepsim+brenduximab?
Complex problem: Cannot comment with 2 lines of information. Need the entire clinical context. If you seek more detailed information get a formal second opinion. ...Read more
If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?
Good Question: Avodart (dutasteride) is extensively metabolized in humans by the cyp3a4 and cyp3a5 isoenzymes. Flomax (tamsulosin) is extensively metabolized, mainly by cyp3a4 and cyp2d6 isoenzymes. Sprycel (dasatinib) is also extensively metabolized by the cyp3a4 isoenzyme but is also a weak time-dependent inhibitor of cyp3a4 and may therefore potentially increase the concentrations of Avodart and flomax. ...Read more
Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets
Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more
Diagnoged with cutaneous tcell lymphoma nhl.Treated with eletron beam.Interferon, gemcitabine, anthracycline, etoposide, procarbazine.Nodules over body .?
Depends: Amer heart assoc recommends both. If you have diabetes, an ace inhibitor is a good choice since it may protect against diabetic kidney disease. You & your doctor should discuss alternative treatments for htn. If you have certain kinds of heart disease, then a beta blocker or diuretic may be a better choice. Thats why it's best to discuss treatment with your doctor. ...Read moreSee 1 more doctor answer
Best first-line treatment for mantle cell lymphoma now: high doses of ara-c+rituximab and autologous sc transplant, or rituximab+bendamustine?
There is no: Definitive answer to your question. Studies have compared the strategies you mention. The high dose ara-c arm was closed because it was difficult to mobilize stem cells for transplant after these regimens. Bendamustine-r is a good program, and many centers would consolidate a good response with an autograft. ...Read more
What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?
Treatment: We always encourage clinical trials as first line option. Standard therapy will include use of taxane and platinum compound like carboplatin/taxol combo. I would not use arimidex. 2nd line drugs include cisplatin, taxotere, doxil, gemzar, avastin, (bevacizumab) topotecan etc. ...Read more
Zytiga (abiraterone acetate) or xtandi for pre-chemo castration resistant prostate cancer? Thoughts?
Diagnoged with cutaneous tcell lymphoma .Treated with eletron beam.Interferon, gemcitabine, anthracycline, etoposide, procarbazine without improv.I'm 64 y?
There are new agents: There are several new agents for this disease. It is uncommon and you need a good assessment of the status of both your disease and your ability to take treatment. There are oral agents, antibodies, drugs like velcade (bortezomib) that might be helpful. I would suggest an evaluation by an oncologist who is familiar with this disease. ...Read moreSee 1 more doctor answer
Yes, for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more
If flomax & avodart (dutasteride) are both cy3a4 substrates & gleevec is an inhibitor why do interaction checkers show a prob. Of gleevec w/flomax but not avodart (dutasteride)?
Complex problem: Different drugs with different levels of cytochrome interference. Follow the checker. ...Read more
What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth
These are brand new: The drugs that you have mentioned are new anticancer drugs which are still experimental, not fda approved for general use. Your doctor(oncologist) has to answer all your questions that you ask before signing up for receiving these drugs. There is not a lot known about them yet. But azd6244 has been tested and found to have some anticancer activity. But more can be found out from your oncologist. ...Read more