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Doctor insights on: Tasigna Vs Sprycel

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What do you suggest if my grandmother has accidently taken three dasatinib tablets for her leukemia instead of two and is worried. Does anyone know what she should do?

What do you suggest if my grandmother has accidently taken three dasatinib tablets for her leukemia instead of two and is worried. Does anyone know what she should do?

CALL ONCOLOGIST: First of all call to inform her oncologist and get his opinion. Dasatinib (sprycel) dose is usually 100 mg daily, so I assume she has 50 mg tablets and was taking 2. It would be appropriate to hold tomorrow's dose and then resume treatment. Call her oncologist. ...Read more

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What will happen if I take three dasatinib by accident instead of two?

What will happen if I take three dasatinib by accident instead of two?

Nothing serious: I do not expect any serious toxicity from a small dose increment of this magnitude. So you do not need to worry or do anything specific. ...Read more

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I have been on sprycel (dasatinib) a little over a year now. I'm hot natured so it rarely makes me cold, but this week I have been freezing. Is this common?

I have been on sprycel (dasatinib) a little over a year now. I'm hot natured so it rarely makes me cold, but this week I have been freezing. Is this common?

Communicate with you: I am sure you have a hematologist/oncologist who gave you this medicine. It is good to communicate with him/her. The answers will be best found by informing your doctor. They may need to check your thyroid functions to be sure you are not hypothyroid. ...Read more

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Usually average 1 cold per year. None since began taking Sprycel (dasatinib) for CML 4 years ago. Do these TKIs have antiviral properties?

Usually average 1 cold per year. None since began taking Sprycel (dasatinib) for CML 4 years ago. Do these TKIs have antiviral properties?

Congratulations: Dasatinib, like imatinib tyrosine kinase inhibitors are great success in cancer treatment for CML etc. Suppressing abnormal white cells defective in combatting infections may have enhanced your body's normal white cells against colds, etc. These molecules block the TKI molecular switches on cells. They do not have antiviral properties. That said, side effects of TKIs include low blood count, takecare ...Read more

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Adding more chemo dasatinib and carboplatin likely to work?

Adding more chemo dasatinib and carboplatin likely to work?

Restate question: Hi jsalyers9. Can you restate your question with a little more information. What is being treated? What treatments have already occurred?

Thanks. ...Read more

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My mom has accidently taken three dasatinib tablets for her leukemia instead of two and is worried. What will happen?

My mom has accidently taken three dasatinib tablets for her leukemia instead of two and is worried. What will happen?

Nothing serious: Taking one extra pill on one day would not make any difference as these drugs have been used at higher doses with minimal increase in toxicity but only when taken at higher dose continuously. But in her case with one extra dose, I do not expect any problems. So she can relax and forget about it. Be careful in future. ...Read more

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Interaction checkers warn against use of tamsulosin with imatnib, a cyp3a4 inhibitor. But dasatinib is a cyp3a4 inhibitor. Why no warnings about it?

Interaction checkers warn against use of tamsulosin with imatnib, a cyp3a4 inhibitor. But dasatinib is a cyp3a4 inhibitor. Why no warnings about it?

See answer: Good question. Both drugs are tkis and both are cyp3a4 inhibitors which have the potential to reduce the metabolism of tamsulosin and thereby the potential for an increase in tamsulosin-associated adverse side effects: dizziness, lightheadedness, drowsiness, runny/stuffy nose, or ejaculation problems being the most common. It may be that imitinib is a stronger cyp3a4 inhibitor than dasatinib. ...Read more

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If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

Good Question: Avodart (dutasteride) is extensively metabolized in humans by the cyp3a4 and cyp3a5
isoenzymes. Flomax (tamsulosin) is extensively metabolized, mainly by cyp3a4 and cyp2d6 isoenzymes. Sprycel (dasatinib) is also extensively metabolized by the cyp3a4 isoenzyme but is also a weak time-dependent inhibitor of cyp3a4 and may therefore potentially increase the concentrations of Avodart and flomax. ...Read more

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Noticed there is a serious interaction between flomax, which I was just prescribed, and gleevec, but none with sprycel, (dasatinib) which I take for cml. Correct?

Noticed there is a serious interaction between flomax, which I was just prescribed, and gleevec, but none with sprycel, (dasatinib) which I take for cml. Correct?

Increase serum Floma: Gleevec increases serum levels of flomax, and therefore dosage adjustment may be necessary.
Flomax is metabolized through cyp3a4 and sprycel (dasatinib) is also a substrate for cyp3a4, so may also increase the levels of flomax. ...Read more

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I felt my heart pulse in my head last night while I was watching TV. I have CML and started on Sprycel (dasatinib). Would that be the reason that happening?

I felt my heart pulse in my head last night while I was watching TV. I have CML and started on Sprycel (dasatinib). Would that be the reason that happening?

It is a coincidence: If your heart is beating faster for any reasons, you may feel the heart beats in any part of the chest or head. This can happen with any emotional upheaval. I do not think that sprycel (dasatinib) has anything to do with it. ...Read more

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Dear sir, can we give Dasatinib to a patient suffering from CLL blast phase with very low WBC / platelets.

Dear sir, can we give Dasatinib to a patient suffering from CLL blast phase with very low WBC / platelets.

Not usual indication: Dasatinib is usually given for blast phase of chronic myeloid leukemia, targeting BcrABL Mutation, a genetic lesion not usually found in blast or Richter's transformation of CLL. ...Read more

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Sudden appearance of very dark blue vein on top of my foot. No pain but some mild tingling. No injury. I do tale dasatinib for cml and am 54.

Keep watch: I would not worry about it unless it does not go away in a few days or gets worse. There is a good Podiatrist in your area if you need it looked at. HVFA in Fishkill; Dr. David Kim. ...Read more

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My pcp, pharmacist and hematologist say no interaction between sprycel (dasatinib) and newly prescribed flomax. Doc on healthtap says there may be. Confused!

My pcp, pharmacist and hematologist say no interaction between sprycel (dasatinib) and newly prescribed flomax. Doc on healthtap says there may be. Confused!

Don`t be confused: You can take both medications together. I rare occasions the level of Flomax (tamsulosin) might be a little higher but it is probably not clinically significant. ...Read more

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CML 10/12. Gleevec. 5 log at 6 mths. Sprycel (dasatinib). 5 log at 6 mths. Stem cell transplant 4/14. 7/14 Blast crisis - 65% blast BM + Aspergillus F lung Help?

Difficult case: It is a complicated case obviously. First and foremost the infection has to be treated. I would suggest you to follow up with ID and oncologist very closely. Importantly is to check if there is certain mutation like T315i mutation as this mutation is resistant to gleevec, sprycel, tasigna (nilotinib) - and should be treated with ponatinib or aurora kinase inhibitor etc. Discuss with oncologist. God bless ...Read more

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Is a 24 month trial of tasigna (nilotinib) the best way to go about treating a cml diagnosis?

YES: Tasigna (nilotinib) - was initially used as sencond line treatment for CML for patients resistant or intolerant to imatinib. Now it is indicated for first line treatment in CML in chronic phase. Its not a trial but treatment for cml. And yes you are right, we only have 24 month data to date as first line treatment. ...Read more

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I have cml. I take 600 mg tasigna-nilotinib daily, and4000 mg vit c per day and 5000iu vit d3. Is it safe to take as much? My doc says yes.

Vitamins: Vitamins a, d, e, & k are fat soluble vitamins and so too much supplement can lead to toxic levels. Vitamin c is water soluble and so excess can be eliminated in the urine. Your likely ok taking the vit d due to your ongoing treatment. However, your physician should check your level every 6 to 12 months to insure the level is optimal and not a risk. ...Read more