Doctor insights on:
Tapering Off Methotrexate In Rheumatisms
Which medication can reduce rheumatoid factor ? my RF is 201. methotrexate not working I take 15 mg weekly one year
RF Factor: RF is a blood test that can be used to evalauted for multiple conditions. In patients with rhumatological conditions there is no evidnece that a drop in the RF value is of any clinical significance while on therapy. The most important considerations for treating RA are the symptoms and any evidnece of joint destruciton on imagining. ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Works: Methotrexate has become the standard of first choice forra treatment but rarely results in remission, ie no one can tell if you have it including the doctor. The risk is extremely low, although you cannot use alcohol, and is not usually used if ther is preexisting liver disease. Most patients have to add several other disease modifying drugs to get better. ...Read more
Good: Usually helps within 2-4 months but rarely produces 100 % remission.Quite low risk. ...Read more
My wife is on 10 pills of methotrexate a week all at once for Rheumatoid Arthritis. Is there an even higher doses for uncontrolled flare ups ?
My rheumatoid facter in last blood test is 201 IU /ML, but I am taking methotrexate 15 mg one year so why my RF still high and what I do to reduce it?
Yes.: My colleagues believe it is the first choice (acr and eular), but while I use it as a second or third drug, the benefit/risk ratio is incredibly good. Methotrexate has little or no justification to be taken orally though. Unpredictable absorption, stomach concenbration build up, and going to the liver on first-pass! the liver sees 600x the ultimate concentration in the blood. ...Read more
See below: He/she may experience a flare in his/her symptoms. Let the doctor know what's going on. ...Read more
I have rheumatoid arthritis and i'm on methotrexate, is it ok to still have breakthrough pain flare ups?
MTX vs Humira (adalimumab): These drugs fight RA in completely different fashions. Mtx is the consensus first round choice of drugs to treat ra, both by the acr and eular (european version). Most, if not all, insurances require treatment failure with mtx before you start humira, (adalimumab) a much more expensive drug. In most cases, even if Humira (adalimumab) is started, patients will remain on mtx. ...Read more