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Doctor insights on: Tamoxifen With Ovarian Suppression

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What are your thoughts of the use of tamoxifen for refractory ovarian cancer?

What are your thoughts of the use of tamoxifen for  refractory  ovarian cancer?

Little: Probably not very beneficial. For uterine cancer, there has been some data. Little if any benefit in ovarian cancer. Unlike breast cancer in which there is a benefit in estrogen positive disease because of the estrogen target, there is no target in ovarian cancer. Hope this helps. ...Read more

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On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

Not necessarily: There are multiple issues in your question and it would be best for you to discuss your symptoms with the doctor presribing your tamoxifen in conjuction with your gynecologist. ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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My FSH was 2.7, estrodial was1340, was on tamoxifen, had a couple of ovarian cysts. Had mastectomy for 1mm bc.Grade 3. Was a bilateral ooph necessary

My FSH was 2.7, estrodial was1340, was on tamoxifen, had a couple of ovarian cysts. Had mastectomy for 1mm bc.Grade 3.  Was a bilateral ooph necessary

Need more info: Your fsh indicates you are not yet in menopause and the cysts could be worrisome. Have you done brca testing or ova1 testing for the cysts? Your doctor may be trying to be proactive and remove the ovaries prior to a potentially worse situation. No real way to accurately determine if someone has ovarian ca without pathology, only an educated guess by ultrasound and lab testing. ...Read more

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What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening . Thanks

What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening .   Thanks

Letrozole: Tamoxifen for 5 years followed by Letrozole would be an option. However, technically you are still premenopausal so not an option. Another treatment which is controversial is to have your ovaries removes. There is data on 10 years of tamoxifen now but you may not want to do this. The other option would be observation. Hope this helps. ...Read more

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How much tamoxifen is recommended?

How much tamoxifen is recommended?

Once per day: Tamoxifen is most commonly used to treat breast cancer. The dose is (usually) 20mg per day and taken for 5 years. This medication is also used for people considered "high risk" for breast cancer to help decrease their risk of developing it in the future. I recommend you speak with your oncologist about specific recommendations for your case. ...Read more

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What are the common benefits of tamoxifen?

What are the common benefits of tamoxifen?

Kill cancer cells: Tamoxifen is a very effective chemotherapeutic agent to treat breast cancers that have the estrogen receptor. Tamoxifen may also be prescribed to prevent breast cancer in high-risk women: a 5-yr regimen may reduce the lifetime risk of breast cancer by 50%. ...Read more

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

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What are the common risk factors for taking tamoxifen?

What are the common risk factors for taking tamoxifen?

Side effects?: The most experienced side effects of all hormonal therapy are menopausal symptoms (ie.Hot flashes, etc). There is a small increased risk of blood clots similar to hormone replacement therapy, in women with an intact uterus, there can be irreg bleeding and thickening of the uterine wall. If ignored this can rarely progress to uterine cancer that can be cured with a hysterectomy. ...Read more

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