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Doctor insights on: Tamoxifen With Ovarian Suppression

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What are your thoughts of the use of tamoxifen for refractory ovarian cancer?

What are your thoughts of the use of tamoxifen for  refractory  ovarian cancer?

Little: Probably not very beneficial. For uterine cancer, there has been some data. Little if any benefit in ovarian cancer. Unlike breast cancer in which there is a benefit in estrogen positive disease because of the estrogen target, there is no target in ovarian cancer. Hope this helps. ...Read more

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On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

Not necessarily: There are multiple issues in your question and it would be best for you to discuss your symptoms with the doctor presribing your tamoxifen in conjuction with your gynecologist. ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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My FSH was 2.7, estrodial was1340, was on tamoxifen, had a couple of ovarian cysts. Had mastectomy for 1mm bc.Grade 3. Was a bilateral ooph necessary

My FSH was 2.7, estrodial was1340, was on tamoxifen, had a couple of ovarian cysts. Had mastectomy for 1mm bc.Grade 3.  Was a bilateral ooph necessary

Need more info: Your fsh indicates you are not yet in menopause and the cysts could be worrisome. Have you done brca testing or ova1 testing for the cysts? Your doctor may be trying to be proactive and remove the ovaries prior to a potentially worse situation. No real way to accurately determine if someone has ovarian ca without pathology, only an educated guess by ultrasound and lab testing. ...Read more

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What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening . Thanks

What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening .   Thanks

Letrozole: Tamoxifen for 5 years followed by Letrozole would be an option. However, technically you are still premenopausal so not an option. Another treatment which is controversial is to have your ovaries removes. There is data on 10 years of tamoxifen now but you may not want to do this. The other option would be observation. Hope this helps. ...Read more

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How much tamoxifen is recommended?

How much tamoxifen is recommended?

Once per day: Tamoxifen is most commonly used to treat breast cancer. The dose is (usually) 20mg per day and taken for 5 years. This medication is also used for people considered "high risk" for breast cancer to help decrease their risk of developing it in the future. I recommend you speak with your oncologist about specific recommendations for your case. ...Read more

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What are the common benefits of tamoxifen?

What are the common benefits of tamoxifen?

Kill cancer cells: Tamoxifen is a very effective chemotherapeutic agent to treat breast cancers that have the estrogen receptor. Tamoxifen may also be prescribed to prevent breast cancer in high-risk women: a 5-yr regimen may reduce the lifetime risk of breast cancer by 50%. ...Read more

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

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What are the common risk factors for taking tamoxifen?

What are the common risk factors for taking tamoxifen?

Side effects?: The most experienced side effects of all hormonal therapy are menopausal symptoms (ie.Hot flashes, etc). There is a small increased risk of blood clots similar to hormone replacement therapy, in women with an intact uterus, there can be irreg bleeding and thickening of the uterine wall. If ignored this can rarely progress to uterine cancer that can be cured with a hysterectomy. ...Read more

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Does tamoxifen affect fertility?

Does tamoxifen affect fertility?

Yes: Tamoxifen is most commonly prescribed for the treatment of hormone (+) breast cancer. While tamoxifen may cause birth defects during pregnancy, it actually can increase ovulation, thus increasing fertility. Accordingly, premenopausal women taking tamoxifen for breast cancer treatment must use (nonhormonal forms of) birth control. ...Read more

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Is letrozole different from tamoxifen?

Is letrozole different from tamoxifen?

Yes: Same general effect - decreases effects of estrogen and improves outcome in er + breast cancer. Mechanism of action (how it works) is different. Letrozole cannot be used in premenopausal women. ...Read more

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What are the side effects of tamoxifen?

Tons: The common ones are bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss. Severe ones are even a more comprehensive list - allergic reactions, vaginal bleeding, chest pain, coughing up blood, dark urine, decreased libido and so .... On. ...Read more

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Is it safe to take tamoxifen every other day?

Is it safe to take tamoxifen every other day?

Speak to your doctor: This is not the usual regimen for tamoxifen. It is usually recommended for daily use and intake for the best effect. Was this recommended by your doctor? If so, you need to find out why this deviates from the standard recommendation. If you are making up your own regimen, please do not proceed until you speak with your physician. ...Read more

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What are the common side effects of tamoxifen?

Menopausal symptoms: The most common side effects of tamoxifen include hot flashes, changes in menstrual period, vaginal dryness, headaches, fatigue, and GI upset. Less common but more serious side effects include blood clots, strokes, uterine cancer, and cataracts. ...Read more

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Is it harmful to stay on tamoxifen for 10 years?

Maybe: Most clinical data has shown benefit of tamoxifen (tam) increasing up to five years. After 5 years it seems to level or possibly even worsen. There may be some cancer cells that not only become resistant but to which tam begins to act as an agonist. That being said there are still the ongoing atlas and atom trials that are trying to get more definite. Another option is ais after 5yrs of tam. ...Read more

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What side effects are associated with tamoxifen?

Side effects: Tamoxifen is often used after treatment for breast cancer to help reduce recurrence. It is very helpful and should be taken if needed and recommended. However it is not w/o side effects which can include increased risk of blood clots, hot flashes, thinning of the bones ( osteoporosis) and endometrial hyperplasia/cancer so if you are concerned d/w dr the risk and benefits as pertains to you. ...Read more

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How can I minimize the side effects of tamoxifen?

Talk with your doc: There are means for dealing with menopausal symptoms/hot flashes. Soy use is controversial but some antidepressants can help but be careful as some also inhibit tamoxifen metabolism. Effexor/venlefaxine is the most studied and does not do this. There are some patients who have achieved great relief with alternative therapies such as accupuncture. ...Read more

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