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Doctor insights on: Tamoxifen With Ovarian Suppression

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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Progesterone and estrogen used for premature ovarian failure?

Progesterone and estrogen used for premature ovarian failure?

Yes: For woman with premature ovarian failure (pof), we recommend hormone replacement therapy, which includes both estrogen and progesterone. The addition of Progesterone is to regulate menstrual period and prevent uterine cancer. For woman desires for pregnancy, we may be able to reduce her fsh level and induce ovulation in some patients. ...Read more

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Can clomiphen or Clomid (clomiphene) used in primary ovarian failure?

Can clomiphen or Clomid (clomiphene) used in primary ovarian failure?

No Clomid (clomiphene) cant be: Hello Clomid (clomiphene) (clomiphen) cannot be used in primary ovarian failure. In primary ovarian failure the ovaries do not produce estrogen to cause ovulation (egg release). Clomid (clomiphene) (clomiphen) works by preventing estrogen from being turned off in the body. If someone does not produce estrogen in the first place than clomid (clomiphene) cannot work. But primary ovarian failure requires a doctor to determine if pt has it ...Read more

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Can endometrial cancer be treated with megace (megestrol)?

Can endometrial cancer be treated with megace (megestrol)?

Yes: Hormonal therapy (including megace (megestrol), (megestrol) tamoxifen) can be used in the treatment of certain endometrial cancers which have recurred or spread to other sites. Patients with tumors positive for the Progesterone receptor especially may respond to megace (megestrol). ...Read more

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Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

YES for ER positive: Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women. Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies. ...Read more

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What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

Treatment options: For stage IV breast cancer- if the cancer progressed after tamoxifen and aromasin- depending on several factors such as how much cancer burder, involvement to visceral organs, overall condition etc- the options would be- faslodex; combination of Aromasin (exemestane) and evorilimus ( based on recent randomized clinical trial) or chemotherapy. Discuss further with your oncologist- which one for your case. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Yes*: Arimidex (anastrozole) belongs to a category of drugs called aromatase inhibitors. These are effective chemotherapeutic agents for people with either estrogen-sensitive or *progesterone-sensitive breast cancers. This is only effective after menopause; premenopausal women may use tamoxifen for a similar response rate. ...Read more

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Does taking tamoxifen benefit women with cdis?

Does taking tamoxifen benefit women with cdis?

Yes.: Women with a history of ductal-carcinoma-in-situ (dcis) may have a 50% reduction in developing a second breast cancer when taking tamoxifen for 5 years ("chemoprevention"). Furthermore, following a lumpectomy, the combination of tamoxifen and radiation therapy may have a decreased risk of cancer recurrence in the affected breast greater than either therapy alone. ...Read more

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Does anastrozole tablets for breast cancer also treat bone cancer in women with metastases?

Does anastrozole tablets for breast cancer also treat bone cancer in women with metastases?

Sort Of: We define cancers by their organ of origin. Therefore, by strict definition, bone cancer originates from bone cells; Anastrozole won't help these rare cancers. More commonly, cancers can spread to bones--we call this bone metastasis. Breast cancer can spread to bones; anastrazole can prevent the spread of certain breast cancers. Hope this helps. ...Read more

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Does having breast, endometrial, and ovarian cancer in family history increase one's risk of endometriosis?

Does having breast, endometrial, and ovarian cancer in family history increase one's risk of endometriosis?

Endo: Having family history of ovarian, colon and uterine cancer specially if these are first degree relatives will put you at risk for cancer not for endometriosis. I would recommend that you talk to your doctor and ask about a brca genetic testing to see if you are a carrier of the gene associated with these types of cancer. ...Read more

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Can a postmenopausal women with antiphospolipid syndrome be treated with bioidentical progesterone and testosterone for symptom relief?

Can a postmenopausal women with antiphospolipid syndrome be treated with bioidentical progesterone and testosterone for symptom relief?

Antiphospholipid: Please look up the "Antiphospholipid syndrome" and carefully read the article on the web. In my opinion , treatment with bio-identical progesterone and testosterone is not related to the antiphospholipid syndrome but you must soon discuss this with your doctor. Please let me know how things turn out. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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