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Doctor insights on: Tamoxifen P450 Genotype

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Is there an alernative to tamoxifen?

Is there an alernative to tamoxifen?

Yes: For breast cancer treatment, aroma taste inhibitors are often used in place of tamoxifen , only in post menopausal women. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What exactly is tamoxifen therapy?

What exactly is tamoxifen therapy?

Anti-estrogen: Tamoxifen is a molecule that can attach to estrogen receptors ( sticky hands on cells that like estrogen). If estrogen (female hormone) binds these receptors it typically causes growth/ turn cell on. Tamoxifen mimics estrogen but can have the opposite effect, hence anti-esteogen. Tamoxifen by attachment can turn cells off (in some breast cells) or turn cell on( in uterus). ...Read more

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

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Why would my doctor tell me to avoid tamoxifen?

Why would my doctor tell me to avoid tamoxifen?

Risks vs. benefits: Tamoxifen is a very effective drug for the prevention and treatment of hormone-sensitive breast cancer. However, like all medications, there are small risks associated with tamoxifen, including a risk of blood clots, stroke, uterine cancer, and cataracts. I would suspect that your dr. Felt that the risks outweighed the benefits in your case or that your cancer was not sensitive to tamoxifen. ...Read more

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How does tamoxifen actually work?

How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow. ...Read more

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Is it safe to take tamoxifen every other day?

Is it safe to take tamoxifen every other day?

Speak to your doctor: This is not the usual regimen for tamoxifen. It is usually recommended for daily use and intake for the best effect. Was this recommended by your doctor? If so, you need to find out why this deviates from the standard recommendation. If you are making up your own regimen, please do not proceed until you speak with your physician. ...Read more

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Does taking tamoxifen benefit women with cdis?

Does taking tamoxifen benefit women with cdis?

Yes.: Women with a history of ductal-carcinoma-in-situ (dcis) may have a 50% reduction in developing a second breast cancer when taking tamoxifen for 5 years ("chemoprevention"). Furthermore, following a lumpectomy, the combination of tamoxifen and radiation therapy may have a decreased risk of cancer recurrence in the affected breast greater than either therapy alone. ...Read more

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Having tamoxifen since 2013, mum just got her period after having none in the last 18 months/ brown to red bleeding with same pain she gets habitually?

Having tamoxifen since 2013, mum just got her period after having none in the last 18 months/ brown to red bleeding with same pain she gets habitually?

Worrisome: After menopause( defined as 12 mo.without a period) any bleeding is abnormal after menopause. This is especially worrisome because of the tamoxifen which does stimulate the growth of the uterine lining. Fortunately, although this can lead to cancer, bleeding usually occurs before cancer so cancer can be prevented. She needs to see her doctor soon. ...Read more

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I have small cuts in my vagina around the clitoris ! It hurts a lot when I clean my self and it's itchy all most of the time ! I'm taking tamoxifen.

I have small cuts in my vagina around the clitoris ! It hurts a lot when I clean my self and it's itchy all most of the time !  I'm taking tamoxifen.

Get prescription: See your provider. I'm so sorry you've dealt with breast cancer! You may need a prescription cream. A steroid cream or possibly combination antifungal/steroid cream may help. See your provider! Good luck. ...Read more

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Female, 32 years old, IDC with two tumors, one 1.4X1.7 and the other .5. Bx results ER+/PR-/HER2-. Ki67 is 50. Plan is mastectomy and tamoxifen for 5 years. Question is does the patient need chemotheraphy as well.

Female, 32 years old, IDC with two tumors, one 1.4X1.7 and the other .5.  Bx results ER+/PR-/HER2-.  Ki67 is 50.  Plan is mastectomy and tamoxifen for 5 years.  Question is does the patient need chemotheraphy as well.

What is nodal status: This is an area of controversy. If lymph nodes contain tumor, the answer is universally yes. If they do not have tumor, many oncologists would say with young age, tumor over 1 cm in size, and multifocal tumors, YES to chemotherapy. Remember that each cancer is unique, and only the doctors that have all of the information can give you the best recommendation. Good luck! ...Read more

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If tumor markers are elevated does it mean tamoxifen isn't working? Dr. Wants to recheck in two weeks. What is next? Had recon surgery in december.

Check again: Not sure what "recon surgery" means but please do not take an elevated tumor marker as a certainty for cancer. You did not say how much it went up but remember there can be lab errors and even if it's a true elevation, it may not have any meaning. A tumor marker can go up for other reasons. I see nothing wrong with repeating one in a short interval. Hope it all goes well. ...Read more

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How effective is taking low-dose tamoxifen for breast cancer risk reduction?

How effective is taking low-dose tamoxifen for breast cancer risk reduction?

Only One Dose: The use of tamoxifen for chemoprevention is associated with a 50% reduction in breast cancer in those at high risk. Like any drug, there are side-effects and potential complications. Therefore, this decision is best made in consultation with a cancer specialist. ...Read more

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How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow. ...Read more

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Who should avoid taking tamoxifen?

Blood clots: Pts with a history of blood clots and/or a history of abnormal pap smears should not take tamoxifen. If there is a family history of clotting disorders or uterine cancer, tamoxifen should not be used. ...Read more

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Which side affects does tamoxifen have?

Minimal: Hot flashes most common. Risk of blood clots (like birth control pills). Also, risk of uterine cancer is higher, but still very low. This risk is only seen in post menopausal women. ...Read more

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What are possible reactions to drug tamoxifen?

3 main ones: 1-blood clots/ strokes 2-endometrial carcinoma 3-cataracts hot flashes/ dryness. ...Read more