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Doctor insights on: Tamoxifen P450 Genotype

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Is there an alernative to tamoxifen?

Is there an alernative to tamoxifen?

Yes: For breast cancer treatment, aroma taste inhibitors are often used in place of tamoxifen , only in post menopausal women. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What exactly is tamoxifen therapy?

What exactly is tamoxifen therapy?

Anti-estrogen: Tamoxifen is a molecule that can attach to estrogen receptors ( sticky hands on cells that like estrogen). If estrogen (female hormone) binds these receptors it typically causes growth/ turn cell on. Tamoxifen mimics estrogen but can have the opposite effect, hence anti-esteogen. Tamoxifen by attachment can turn cells off (in some breast cells) or turn cell on( in uterus). ...Read more

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

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Why would my doctor tell me to avoid tamoxifen?

Risks vs. benefits: Tamoxifen is a very effective drug for the prevention and treatment of hormone-sensitive breast cancer. However, like all medications, there are small risks associated with tamoxifen, including a risk of blood clots, stroke, uterine cancer, and cataracts. I would suspect that your dr. Felt that the risks outweighed the benefits in your case or that your cancer was not sensitive to tamoxifen. ...Read more

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How does tamoxifen actually work?

How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow. ...Read more

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Is it safe to take tamoxifen every other day?

Is it safe to take tamoxifen every other day?

Speak to your doctor: This is not the usual regimen for tamoxifen. It is usually recommended for daily use and intake for the best effect. Was this recommended by your doctor? If so, you need to find out why this deviates from the standard recommendation. If you are making up your own regimen, please do not proceed until you speak with your physician. ...Read more

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Does taking tamoxifen benefit women with cdis?

Does taking tamoxifen benefit women with cdis?

Yes.: Women with a history of ductal-carcinoma-in-situ (dcis) may have a 50% reduction in developing a second breast cancer when taking tamoxifen for 5 years ("chemoprevention"). Furthermore, following a lumpectomy, the combination of tamoxifen and radiation therapy may have a decreased risk of cancer recurrence in the affected breast greater than either therapy alone. ...Read more

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