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Doctor insights on: Tamoxifen P450 Genotype

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What is longterm prognosis for grade 3, stage 1b, triple positive breast cancer, double mastectomy and 6 treatments of TCH with one year of herceptin, (trastuzumab)?

What is longterm prognosis for grade 3, stage 1b, triple positive breast cancer, double mastectomy and 6 treatments of TCH with one year of herceptin, (trastuzumab)?

Better now: Exact prognosis is not possible, but your oncologist should discuss your prognosis with based on population statistics, such as Adjuvant! Online, or better still, your Oncotype Dx score based on the gene profile of your cancer. ...Read more

Dr. Sean Canale
639 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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Is there an alernative to tamoxifen?

Is there an alernative to tamoxifen?

Yes: For breast cancer treatment, aroma taste inhibitors are often used in place of tamoxifen , only in post menopausal women. ...Read more

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Survival rate for triple neg receptors for early stage breast cancer after chemo treatment? No lymph nodes involve, stage 1b, grade 2, mastec done

Survival rate for triple neg receptors for early stage breast cancer after chemo treatment?  No lymph nodes involve, stage 1b, grade 2, mastec done

Excellent: According to adjuvant online (www.Adjuvantonline.Com), you have about an 82% 10 yr survival rate based on your specific information provided. This is only an estimate since there are details I do not have such as type of chemotherapy being used. For triple negative breast cancer, these survival rates are quite excellent. ...Read more

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Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good medicn?

Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good  medicn?

Not fertility meds: The medications you are describing are several antibiotics, vitamins and enzymes. None of these are infertility medications. If you are not sure why he/she prescribed them, you should ask your doctor what they are for. ...Read more

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What exactly is tamoxifen therapy?

What exactly is tamoxifen therapy?

Anti-estrogen: Tamoxifen is a molecule that can attach to estrogen receptors ( sticky hands on cells that like estrogen). If estrogen (female hormone) binds these receptors it typically causes growth/ turn cell on. Tamoxifen mimics estrogen but can have the opposite effect, hence anti-esteogen. Tamoxifen by attachment can turn cells off (in some breast cells) or turn cell on( in uterus). ...Read more

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Dr. Liawaty Ho Dr. Ho
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CML 10/12. Gleevec .5 log at 6 mths. Sprycel (dasatinib) .5 log at 6 mths. Stem cell transplant 4/14. 7/14 Blast crisis - 65% blast BM + Aspergillus F lung Help?

Dr. Liawaty Ho Dr. Ho
1 doctor agreed:
CML 10/12. Gleevec .5 log at 6 mths. Sprycel (dasatinib) .5 log at 6 mths. Stem cell transplant 4/14.  7/14 Blast crisis - 65% blast BM + Aspergillus F lung Help?

Difficult case: it is a complicated case obviously. first and foremost the infection has to be treated. i would suggest you to follow up with ID and oncologist very closely. importantly is to check if there is certain mutation like T315i mutation as this mutation is resistant to gleevec, sprycel, tasigna (nilotinib) - and should be treated with ponatinib or aurora kinase inhibitor etc. discuss with oncologist. God bless ...Read more

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

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Male 55 healthy/active prostate cancer, scheduled for rp, psa 6.5 biopsies 6of8 pos 2aggessive, gleason 7. Are there other options to consider other than surg. Ct and bone scan clear. ?

Male 55 healthy/active prostate cancer, scheduled for rp, psa 6.5 biopsies 6of8 pos 2aggessive, gleason 7. Are there other options to consider other than surg. Ct and bone scan clear. ?

Yes but: Alternatives are external beam radiation and radiation seeds (brachytherapy). At your age, conservative (watching) isn't advised. All of the therapies can cause urinary incontinence and e.D. - with surgery, they get better over time for most. With radiation, they get worse over time. Surgery is the time honored best of a bad situation. Good luck. ...Read more

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Petrified been taking prometrium 200 mg daily due to estrogen dominance does this bioidentical hormone increase my chances of breast cancer ?

Petrified been taking prometrium 200 mg daily due to estrogen dominance does this bioidentical hormone increase my chances of breast cancer ?

Very complex issue: The decision to take hormone therapy is quite complex & should be handled on a one on one basis. The doctor should evaluate each patients individual risk of breast cancer. Treatment should be at the lowest dose that alleviates the menopausal symptoms. There's a very small increase relative risk in breast cancer diagnosis. In symptomatic low risk women the benefit may outweigh the risk ...Read more

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Why would my doctor tell me to avoid tamoxifen?

Why would my doctor tell me to avoid tamoxifen?

Risks vs. benefits: Tamoxifen is a very effective drug for the prevention and treatment of hormone-sensitive breast cancer. However, like all medications, there are small risks associated with tamoxifen, including a risk of blood clots, stroke, uterine cancer, and cataracts. I would suspect that your dr. Felt that the risks outweighed the benefits in your case or that your cancer was not sensitive to tamoxifen. ...Read more

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Any hypertensive meds that don't cause hair loss? Vasotec, lebatalol, diovan, bystolic (nebivolol) work but cause hair loss. Benicar doesn't reduce dystolic #.

Any hypertensive meds that don't cause hair loss? Vasotec, lebatalol, diovan, bystolic (nebivolol) work but cause hair loss. Benicar doesn't reduce dystolic #.

Unusual side effect: I have treated pts for forty years, and i can't remember that complained of hair loss after starting any of these agents. That does not mean it never happens (one lesson i've learned in medicine is never say never). Every drug has a huge list of adverse effects because each one a pt complains of in a study gets listed. Vasotec is an ace, Diovan (valsartan) & Benicar r arb's, same effects. Hair loss unlikely. ...Read more

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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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How does tamoxifen actually work?

How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow. ...Read more

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W 30 yo. low HDL (0.85 vs 1.3 max ), high triglycerides (1,74), neutrophile (8 vs 7,5 max), normal LDL 2.15, hba1c 5.2 and fgp 4,6, TSH 2.23.no medica?

W 30 yo. low HDL (0.85 vs 1.3 max ), high triglycerides (1,74), neutrophile (8 vs 7,5 max), normal LDL 2.15, hba1c 5.2 and fgp 4,6, TSH 2.23.no medica?

Lab data: It is very difficult, if not impossible to interpret lab data in the absence of clinical information or relevance. My advice is to discuss this with the doctor who ordered these tests and not try to self-diagnose over the internet. Best wishes. ...Read more

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Can a patient stage 1 papillary thyroid cancer with BRAF mutation positive live more than 20 years ( she is 51 years old) ? Thank you very much!

Can a patient stage 1 papillary thyroid cancer with BRAF mutation positive live more than 20 years ( she is 51 years old) ? Thank you very much!

Yes: Papillary thyroid cancer is very common and some people do not even know they have it as small tumors may be found on autopsy when they die of something else. Generally tumors are graded by how ugly they look to the pathologist and how far they've spread. Your tumor has also been molecularly characterized. There are new treatment options available. Please discuss with your oncologist. ...Read more