Top
20
Doctor insights on: Tamoxifen Femara

Share
1

1
What is the difference between tamoxifen and femara (letrozole)?

What is the difference between tamoxifen and femara (letrozole)?

Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read more

See 1 more doctor answer
Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


2

2
What are the similarities and differences between tamoxifen and femara (letrozole)?

What are the similarities and differences between tamoxifen and femara (letrozole)?

Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read more

See 1 more doctor answer
3

3
What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

Treatment options: For stage IV breast cancer- if the cancer progressed after tamoxifen and aromasin- depending on several factors such as how much cancer burder, involvement to visceral organs, overall condition etc- the options would be- faslodex; combination of Aromasin (exemestane) and evorilimus ( based on recent randomized clinical trial) or chemotherapy. Discuss further with your oncologist- which one for your case. ...Read more

See 1 more doctor answer
4

4
What are some similarities and differences between tamoxefen and femara (letrozole)?

Requires long answer: The answer is too long to fit into 400 characters but there is a nice summary at http://www.Health.Com/health/condition-article/0, 20188924, 00.Html. ...Read more

See 1 more doctor answer
5

5
How much tamoxifen is recommended?

How much tamoxifen is recommended?

Once per day: Tamoxifen is most commonly used to treat breast cancer. The dose is (usually) 20mg per day and taken for 5 years. This medication is also used for people considered "high risk" for breast cancer to help decrease their risk of developing it in the future. I recommend you speak with your oncologist about specific recommendations for your case. ...Read more

6

6
What are the common benefits of tamoxifen?

Kill cancer cells: Tamoxifen is a very effective chemotherapeutic agent to treat breast cancers that have the estrogen receptor. Tamoxifen may also be prescribed to prevent breast cancer in high-risk women: a 5-yr regimen may reduce the lifetime risk of breast cancer by 50%. ...Read more

See 1 more doctor answer
7

7
Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

8

8
What are the common risk factors for taking tamoxifen?

What are the common risk factors for taking tamoxifen?

Side effects?: The most experienced side effects of all hormonal therapy are menopausal symptoms (ie.Hot flashes, etc). There is a small increased risk of blood clots similar to hormone replacement therapy, in women with an intact uterus, there can be irreg bleeding and thickening of the uterine wall. If ignored this can rarely progress to uterine cancer that can be cured with a hysterectomy. ...Read more

See 1 more doctor answer
9

9
Does tamoxifen affect fertility?

Does tamoxifen affect fertility?

Yes: Tamoxifen is most commonly prescribed for the treatment of hormone (+) breast cancer. While tamoxifen may cause birth defects during pregnancy, it actually can increase ovulation, thus increasing fertility. Accordingly, premenopausal women taking tamoxifen for breast cancer treatment must use (nonhormonal forms of) birth control. ...Read more

See 1 more doctor answer
10

10
Is letrozole different from tamoxifen?

Is letrozole different from tamoxifen?

Yes: Same general effect - decreases effects of estrogen and improves outcome in er + breast cancer. Mechanism of action (how it works) is different. Letrozole cannot be used in premenopausal women. ...Read more

See 1 more doctor answer
11

11
What are the side effects of tamoxifen?

Tons: The common ones are bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss. Severe ones are even a more comprehensive list - allergic reactions, vaginal bleeding, chest pain, coughing up blood, dark urine, decreased libido and so .... On. ...Read more

See 1 more doctor answer
12

12
Is it safe to take tamoxifen every other day?

Is it safe to take tamoxifen every other day?

Speak to your doctor: This is not the usual regimen for tamoxifen. It is usually recommended for daily use and intake for the best effect. Was this recommended by your doctor? If so, you need to find out why this deviates from the standard recommendation. If you are making up your own regimen, please do not proceed until you speak with your physician. ...Read more

14

14
What are the common side effects of tamoxifen?

Menopausal symptoms: The most common side effects of tamoxifen include hot flashes, changes in menstrual period, vaginal dryness, headaches, fatigue, and GI upset. Less common but more serious side effects include blood clots, strokes, uterine cancer, and cataracts. ...Read more

See 1 more doctor answer
16

16
Is it harmful to stay on tamoxifen for 10 years?

Maybe: Most clinical data has shown benefit of tamoxifen (tam) increasing up to five years. After 5 years it seems to level or possibly even worsen. There may be some cancer cells that not only become resistant but to which tam begins to act as an agonist. That being said there are still the ongoing atlas and atom trials that are trying to get more definite. Another option is ais after 5yrs of tam. ...Read more

See 1 more doctor answer
17

17
What side effects are associated with tamoxifen?

Side effects: Tamoxifen is often used after treatment for breast cancer to help reduce recurrence. It is very helpful and should be taken if needed and recommended. However it is not w/o side effects which can include increased risk of blood clots, hot flashes, thinning of the bones ( osteoporosis) and endometrial hyperplasia/cancer so if you are concerned d/w dr the risk and benefits as pertains to you. ...Read more

18

18
How can I minimize the side effects of tamoxifen?

Talk with your doc: There are means for dealing with menopausal symptoms/hot flashes. Soy use is controversial but some antidepressants can help but be careful as some also inhibit tamoxifen metabolism. Effexor/venlefaxine is the most studied and does not do this. There are some patients who have achieved great relief with alternative therapies such as accupuncture. ...Read more

See 1 more doctor answer
19

19
Anyone know any sites to buy nolvadex (tamoxifen)?

Anyone know any sites to buy nolvadex (tamoxifen)?

Nolvadex (tamoxifen): Sorry, only by prescription, assuming u care about the quality of the medication. ...Read more

20

20
Why should I not combine sage tablets with tamoxifen?

Why should I not combine sage tablets with tamoxifen?

Unclear: There is very little hard data about sage extract. The online advertisers say that sage is a mild estrogen type extract that helps menopausal symptoms. I am not sure if that claim has been validated. Tamoxifen works by blocking the body's estrogen and "starving" the tumor. If sage actually does work, then it would get in the way of tamoxifen's intended effect. ...Read more

See 1 more doctor answer