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Doctor insights on: Tamoxifen Femara

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What is the difference between tamoxifen and femara (letrozole)?

What is the difference between tamoxifen and femara (letrozole)?

Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What are the similarities and differences between tamoxifen and femara (letrozole)?

What are the similarities and differences between tamoxifen and femara (letrozole)?

Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read more

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What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

What should a person with breast cancer IV take after tamoxifen and aromasin. Arimidex femara or faslodex (fulvestrant)?

Treatment options: For stage IV breast cancer- if the cancer progressed after tamoxifen and aromasin- depending on several factors such as how much cancer burder, involvement to visceral organs, overall condition etc- the options would be- faslodex; combination of Aromasin (exemestane) and evorilimus ( based on recent randomized clinical trial) or chemotherapy. Discuss further with your oncologist- which one for your case. ...Read more

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What are some similarities and differences between tamoxefen and femara (letrozole)?

Requires long answer: The answer is too long to fit into 400 characters but there is a nice summary at http://www.Health.Com/health/condition-article/0, 20188924, 00.Html. ...Read more

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How much tamoxifen is recommended?

How much tamoxifen is recommended?

Once per day: Tamoxifen is most commonly used to treat breast cancer. The dose is (usually) 20mg per day and taken for 5 years. This medication is also used for people considered "high risk" for breast cancer to help decrease their risk of developing it in the future. I recommend you speak with your oncologist about specific recommendations for your case. ...Read more

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What are the common benefits of tamoxifen?

Kill cancer cells: Tamoxifen is a very effective chemotherapeutic agent to treat breast cancers that have the estrogen receptor. Tamoxifen may also be prescribed to prevent breast cancer in high-risk women: a 5-yr regimen may reduce the lifetime risk of breast cancer by 50%. ...Read more

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors. ...Read more

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What are the common risk factors for taking tamoxifen?

What are the common risk factors for taking tamoxifen?

Side effects?: The most experienced side effects of all hormonal therapy are menopausal symptoms (ie.Hot flashes, etc). There is a small increased risk of blood clots similar to hormone replacement therapy, in women with an intact uterus, there can be irreg bleeding and thickening of the uterine wall. If ignored this can rarely progress to uterine cancer that can be cured with a hysterectomy. ...Read more

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Does tamoxifen affect fertility?

Yes: Tamoxifen is most commonly prescribed for the treatment of hormone (+) breast cancer. While tamoxifen may cause birth defects during pregnancy, it actually can increase ovulation, thus increasing fertility. Accordingly, premenopausal women taking tamoxifen for breast cancer treatment must use (nonhormonal forms of) birth control. ...Read more

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Is letrozole different from tamoxifen?

Yes: Same general effect - decreases effects of estrogen and improves outcome in er + breast cancer. Mechanism of action (how it works) is different. Letrozole cannot be used in premenopausal women. ...Read more

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