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Doctor insights on: Tamoxifen Breast Hormone Receptors

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Should I take tamoxifen to reduce the risk of a new tumor if my breast tumor does not have hormone receptors?

Should I take tamoxifen to reduce the risk of a new tumor if my breast tumor does not have hormone receptors?

No: At this time, we don't have any research evidence showing benefit of tamoxifen if your breast cancer was negative for the estrogen and Progesterone receptor. Tamoxifen has risks (blood clots, stroke, uterine cancer) and side effects, so it should not be taken without a good reason. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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Is single duct l nipple clear d/c ever just hormones? Prolactin level good and breast sono of nipple clear.

Is single duct l nipple clear d/c ever just hormones? Prolactin level good and breast sono of nipple clear.

Please read this: Video: if i had - unilateral nipple discharge - dr. Sarah a ... www.insidermedicine.com/archives/video_if_i_had... There is an excellent discussion of your symptom along with statistics that are much in your favor, but which nonetheless require a full work-up. Play it safe and have this evaluated fully. You will understand after your done with the article. ...Read more

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Can leaving in a implant contraceptive cause over production of prolactin or detrimental hormone fluctuations? Tenderness and size increase in breasts

Can leaving in a implant contraceptive cause over production of prolactin or detrimental hormone fluctuations? Tenderness and size increase in breasts

No: But i'm not sure what evidence you have that your prolactin is elevated. Breast enlargement and/or tenderness can be a side effect of hormonal contraception (such as implanon/nexplanon). Prolactin elevations usually cause milk production. ...Read more

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Chemotherapy hormone receptor positive node breast cancer?

Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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What is the relationship of her2 and p53 with hormone receptors in breast cancer?

What is the relationship of her2 and p53 with hormone receptors in breast cancer?

Complicated: Her-2 is an oncogene usually (not always) associated with er- tumors. We know that it is in general associated with a worse prognosis, but women with her 2+ tumors may respond dramatically to Herceptin (trastuzumab) - a monoclonal antibody. P53 is a tumor suppressor gene. The relationship between p53 and er is currently under study - it may be that p53 mutations may play a role in tamoxifen responsiveness. ...Read more

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Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Often: There is increasing data based on the oncotype DX test in women with 1-3 positive notes that shows that some women will not get much benefit from chemo and some will get a great deal. It can be useful in cases where a woman is reluctant to take chemo. This is done on tissue that has been already removed. Most oncologists believe that women who have multiple positive nodes should get chemotherapy. ...Read more

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Does tamoxifen stop breast cancer from growing?

Does tamoxifen stop breast cancer from growing?

Yes: Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. ...Read more

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Can tamoxifen stop the growth of breast cancer?

Can tamoxifen stop the growth of breast cancer?

Sometimes,: Depending on type of cancer, especially hormone receptor status. But it really depends on specific circumstances whether this drug, or any drug, is appropriate drug for you. So you need to ask your doctor for specific advice. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Are there any other alternatives to tamoxifen for breast cancer?

Are there any other alternatives to tamoxifen for breast cancer?

Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read more

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What could happen if someone took tamoxifen if they didn't have breast cancer?

What could happen if someone took tamoxifen if they didn't have breast cancer?

Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more

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I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

May surprise you but: ...Folks with high risk for breast cancer (without cancer) can take it to reduce their risk. It's not for everybody and should be done under the care of a specialist in the field. Anybody else will get the side effects (hot flashes and increased risk for blood clots and uterine cancer) for no gain at all. ...Read more

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Does tamoxifen help prevent breast cancer?

Does tamoxifen help prevent breast cancer?

And new primaries: Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%. ...Read more

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When do breast cancer patients need tamoxifen ?

Tamoxifen: A selective estrogen receptor modulator is effective added therapy for women with well-differentiated, estrogen receptor positive breast cancers. ...Read more

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Can tamoxifen or raloxifene reduce male breasts (gynemostia)?

Can tamoxifen or raloxifene reduce male breasts (gynemostia)?

No.: Male breast enlargement at age 79 is usually due to weight gain and decreasing testosterone, not excess estrogens. Anti-estrogen drugs are not indicated, but full endocrine work up can eliminate hormonal concerns. Gynecomastia is treated with plastic surgery to excise any glandular component (very fibrotic) and liposuction for fatty components. Large breast may require skin removal and tailoring. ...Read more

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Is tamoxifen effective only if the cancer has not spread outside of the breast?

Is tamoxifen effective only if the cancer has not spread outside of the breast?

On the Contrary: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers that has spread outside the breast. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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What is the role of tamoxifen in the treatment of breast cancer?

Anti-estrogen: Tamoxifen is one of the anti-estrogen agents used to treat breast cancer. Cancers that exhibit an estrogen receptor (er positive tumors) are treated in part by blocking the estrogen that act as signals to these tumors to grow. ...Read more

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Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


Dr. Lois Freisleben-Cook
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Hormone (Definition)

A hormone (from greek ὁρμή, "impetus") is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a little amount of hormone is required to alter cell metabolism. In essence, it is a chemical messenger that transports a signal from ...Read more