Doctor insights on:
Tamoxifen Breast Cancer Put Uterine
Yes. like ERT: The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. ...Read moreSee 1 more doctor answer
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
3 years ago i had breast cancer.Had chemotherapy was put on tamoxifen then letrozole, now have complex cyst on uterus.How likely is this to be cancer?
I have uterine fibroids & therefore hesitant to take tamoxifen. Are there other alternatives to tamoxifen for breast cancer patients?
Yes your doctor can: Your doctor(oncologist) can help address this problem. Tamoxifen is safe to use despite having Fibroids. But there is another medicine which can be used instead of tamoxifen especially in women over the age of 50 years. These drugs called AIs(Letrozole and Anastrozole) are more commonly used instead of tamoxifen at the present time./ ...Read more
Yes, it does: Yes! tamoxifen is a quirky drug! it binds to the estrogen receptor on cells, and in most places blocks the activity of estrogen. But in some places, including the uterus, tamoxifen turns on the receptor instead of turning it off. This causes the lining of the uterus to build up and get thick. This slightly increases the risk of uterine cancer, especially in older women. ...Read moreSee 1 more doctor answer
Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read moreSee 1 more doctor answer
Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read moreSee 1 more doctor answer
My mom 66 just diagnosed with breast cancer, metastasis to bones, stomach&lung t3n2m1. Put on tamoxifen for 2 mnths.Can she benefit from surgery?Whats her survival rate in years?How to extend her life?
What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening . Thanks
Letrozole: Tamoxifen for 5 years followed by Letrozole would be an option. However, technically you are still premenopausal so not an option. Another treatment which is controversial is to have your ovaries removes. There is data on 10 years of tamoxifen now but you may not want to do this. The other option would be observation. Hope this helps. ...Read moreSee 1 more doctor answer
It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read moreSee 2 more doctor answers
Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read moreSee 2 more doctor answers
Yes: Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. ...Read moreSee 1 more doctor answer
Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more
And new primaries: Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%. ...Read moreSee 4 more doctor answers
Simple question from a breast cancer patien, she have only 20mg nolvadex (tamoxifen) and need 10mg a day can she split the 20mg tablet in half?
Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read moreSee 1 more doctor answer
Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more
This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more
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