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Doctor insights on: Tamoxifen Breast Cancer Put Uterine

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Does tamoxifen for breast cancer put me at risk for uterine cancer?

Does tamoxifen for breast cancer put me at risk for uterine cancer?

Yes. like ERT: The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. ...Read more

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Dr. Barry Rosen
4,369 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Do the breast enhancement pills "breast actives" cause breast cancer or uterus cancer?

Do the breast enhancement pills "breast actives" cause breast cancer or uterus cancer?

Unknown: Breast enhancement pills are not regulated and therefore may have various unknown substances in them. Some of those substances, especially if they include estrogen, may increase risk of cancers. ...Read more

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Does tamoxifen stop breast cancer from growing?

Does tamoxifen stop breast cancer from growing?

Yes: Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. ...Read more

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Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

YES for ER positive: Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women. Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies. ...Read more

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Does breast cancer increase colon cancer risk?

Does breast cancer increase colon cancer risk?

Rarely.: Some hereditary mutations may increase the risk of both breast and colon cancer. Nevertheless, the majority of all breast and colon cancers are not hereditary. ...Read more

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Can thyroid cancer increase breast cancer risk?

Can thyroid cancer increase breast cancer risk?

Not usually: There are some families who have increased rates of a variety of cancers, including papillary thyroid cancer, breast cancer, and colon cancer. But having one does not cause an risk for another; instead inherited genes put a person at increased risk for both. A person with a history of thyroid cancer should be sure to get recommended mammograms and colon tests. ...Read more

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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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Silicone breast implants can couse breast cancer?

Silicone breast implants can couse breast cancer?

No but.....: There is no direct link but there are concerns with the potential for implants to interfere with the detection of cancer. Particularly using mammograms. Special views (eklund) must be obtained. Alhtough there may be a delay in diagnosis, there has not been shown to be any effect on survival. With mri, surveillance is improved and may supplant mammography. As stated, alcl may be increased but rare. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Does uterine cancer increase the risk for colon cancer?

Does uterine cancer increase the risk for colon cancer?

Sometimes: There is a familial disorder known as lynch syndrome which increases both the risk of colon cancer and endometrial (uterine) cancer. About 5% of all colon cancers are caused by lynch syndrome. If a family has multiple cases of both colon and endometrial cancer or colon cancer under the age of 40, lynch syndrome should be considered. ...Read more

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Does tamoxifen cause uterine cancer?

Does tamoxifen cause uterine cancer?

It can.: The most definitive study that looked at uterine cancer rates associated with tamoxifen found that women had twice the risk of developing uterine cancer, at a rate of 1 per 500 women per year. This rate is far lower than the rate of breast cancer prevention; thus, the benefits far outweigh the risks. A better alternative after menopause is aromatase inhibitors, which do not increase this risk. ...Read more

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Can tamoxifen stop the growth of breast cancer?

Can tamoxifen stop the growth of breast cancer?

Sometimes,: Depending on type of cancer, especially hormone receptor status. But it really depends on specific circumstances whether this drug, or any drug, is appropriate drug for you. So you need to ask your doctor for specific advice. ...Read more

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Does tamoxifen help prevent breast cancer?

Does tamoxifen help prevent breast cancer?

And new primaries: Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

Dr. John Yim Dr. Yim
3 doctors agreed:
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Does breast bondage causing breast cancer?

Dr. John Yim Dr. Yim
3 doctors agreed:
Does breast bondage causing breast cancer?

No.: Breast bondage does not cause breast cancer and almost certainly has no effect on raising the risk of breast cancer. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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Does having breast, endometrial, and ovarian cancer in family history increase one's risk of endometriosis?

Does having breast, endometrial, and ovarian cancer in family history increase one's risk of endometriosis?

Endo: Having family history of ovarian, colon and uterine cancer specially if these are first degree relatives will put you at risk for cancer not for endometriosis. I would recommend that you talk to your doctor and ask about a brca genetic testing to see if you are a carrier of the gene associated with these types of cancer. ...Read more

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Does tamoxifen for breast cancer put me at risk for uterine cancer?

Yes. like ERT: The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. ...Read more

See 1 more doctor answer
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I have uterine fibroids & therefore hesitant to take tamoxifen. Are there other alternatives to tamoxifen for breast cancer patients?

I have uterine fibroids & therefore hesitant to take tamoxifen.  Are there other alternatives to tamoxifen for breast cancer patients?

Yes your doctor can: Your doctor(oncologist) can help address this problem. Tamoxifen is safe to use despite having Fibroids. But there is another medicine which can be used instead of tamoxifen especially in women over the age of 50 years. These drugs called AIs(Letrozole and Anastrozole) are more commonly used instead of tamoxifen at the present time./ ...Read more

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Can the intake of tamoxifen for breast cancer affect our uterus ?

Yes, it does: Yes! tamoxifen is a quirky drug! it binds to the estrogen receptor on cells, and in most places blocks the activity of estrogen. But in some places, including the uterus, tamoxifen turns on the receptor instead of turning it off. This causes the lining of the uterus to build up and get thick. This slightly increases the risk of uterine cancer, especially in older women. ...Read more

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Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read more

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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My mom 66 just diagnosed with breast cancer, metastasis to bones, stomach&lung t3n2m1. Put on tamoxifen for 2 mnths.Can she benefit from surgery?Whats her survival rate in years?How to extend her life?

My mom 66 just diagnosed with breast cancer, metastasis to bones, stomach&lung t3n2m1. Put on tamoxifen for 2 mnths.Can she benefit from surgery?Whats her survival rate in years?How to extend her life?

Need more than that: Yes if primary tumor is not removed , yes she will debunking will help , needs more than tamoxifen , speak to the oncologist for chemotherapy . Recent advances in chemotherapy changing the survival rate from 23% for better . Good luck. ...Read more

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What could replace tamoxiphen in second 5 years after breast cancer? Tamoxiphen caused me ovarian cyst and uterus thickening . Thanks

Letrozole: Tamoxifen for 5 years followed by Letrozole would be an option. However, technically you are still premenopausal so not an option. Another treatment which is controversial is to have your ovaries removes. There is data on 10 years of tamoxifen now but you may not want to do this. The other option would be observation. Hope this helps. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Dr. Eugene Ahn Dr. Ahn
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Are there any other alternatives to tamoxifen for breast cancer?

Dr. Eugene Ahn Dr. Ahn
3 doctors agreed:
Are there any other alternatives to tamoxifen for breast cancer?

Additional info: Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. ...Read more

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When do breast cancer patients need tamoxifen ?

Tamoxifen: A selective estrogen receptor modulator is effective added therapy for women with well-differentiated, estrogen receptor positive breast cancers. ...Read more

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What is the role of tamoxifen in the treatment of breast cancer?

Anti-estrogen: Tamoxifen is one of the anti-estrogen agents used to treat breast cancer. Cancers that exhibit an estrogen receptor (er positive tumors) are treated in part by blocking the estrogen that act as signals to these tumors to grow. ...Read more

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Does tamoxifen stop breast cancer from growing?

Yes: Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. ...Read more

See 1 more doctor answer
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Can tamoxifen stop the growth of breast cancer?

Sometimes,: Depending on type of cancer, especially hormone receptor status. But it really depends on specific circumstances whether this drug, or any drug, is appropriate drug for you. So you need to ask your doctor for specific advice. ...Read more

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What could happen if someone took tamoxifen if they didn't have breast cancer?

What could happen if someone took tamoxifen if they didn't have breast cancer?

Talk to your doctor: Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. ...Read more

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Does tamoxifen help prevent breast cancer?

And new primaries: Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%. ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer?

Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Dr. Sean Canale
639 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


Dr. Mark Hoepfner
1,067 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more