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Doctor insights on: Tamoxifen And Endometrial Cancer

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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

Dr. Barry Rosen
4,366 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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Does tamoxifen for breast cancer put me at risk for uterine cancer?

Does tamoxifen for breast cancer put me at risk for uterine cancer?

Yes. like ERT: The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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Does uterine cancer increase the risk for colon cancer?

Does uterine cancer increase the risk for colon cancer?

Sometimes: There is a familial disorder known as lynch syndrome which increases both the risk of colon cancer and endometrial (uterine) cancer. About 5% of all colon cancers are caused by lynch syndrome. If a family has multiple cases of both colon and endometrial cancer or colon cancer under the age of 40, lynch syndrome should be considered. ...Read more

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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read more

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Can ovarian cancer and breast cancer be hereditary?

Can ovarian cancer and breast cancer be hereditary?

Yes, of course: This is one of the classic hereditary cancer syndromes. Sorry, i don't have enough characters to be allowed to give you a full asnwer here, but quoting wikipedia: http://en.Wikipedia.Org/wiki/hereditary_breast%e2%80%93ovarian_cancer_syndrome. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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Does having breast, endometrial, and ovarian cancer in family history increase one's risk of endometriosis?

Does having breast, endometrial, and ovarian cancer in family history increase one's risk of endometriosis?

Endo: Having family history of ovarian, colon and uterine cancer specially if these are first degree relatives will put you at risk for cancer not for endometriosis. I would recommend that you talk to your doctor and ask about a brca genetic testing to see if you are a carrier of the gene associated with these types of cancer. ...Read more

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Can tamoxifen stop the growth of breast cancer?

Can tamoxifen stop the growth of breast cancer?

Sometimes,: Depending on type of cancer, especially hormone receptor status. But it really depends on specific circumstances whether this drug, or any drug, is appropriate drug for you. So you need to ask your doctor for specific advice. ...Read more

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Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

YES for ER positive: Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women. Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies. ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Does tamoxifen cause uterine cancer?

Does tamoxifen cause uterine cancer?

It can.: The most definitive study that looked at uterine cancer rates associated with tamoxifen found that women had twice the risk of developing uterine cancer, at a rate of 1 per 500 women per year. This rate is far lower than the rate of breast cancer prevention; thus, the benefits far outweigh the risks. A better alternative after menopause is aromatase inhibitors, which do not increase this risk. ...Read more

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Is endometrical cancer the same cancer as ulterine cancer?

Is endometrical cancer the same cancer as ulterine cancer?

Essentially yes.: This is basically the term for uterine cancer as endometrial cancer comprises most of the cancers in the uterus. There can be myometrial cancer, or cancer of the muscular layer of the uterus, and also leiomyoma/fibroid tumor, another benign tumor in the muscle layer of the uterus that has malignant variants, but these would be specified in diagnosis. But, overall, this is usually what it means. ...Read more

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Are breast cancer and colon cancer linked?

Are breast cancer and colon cancer linked?

Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read more

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Does anastrozole tablets for breast cancer also treat bone cancer in women with metastases?

Does anastrozole tablets for breast cancer also treat bone cancer in women with metastases?

Sort Of: We define cancers by their organ of origin. Therefore, by strict definition, bone cancer originates from bone cells; Anastrozole won't help these rare cancers. More commonly, cancers can spread to bones--we call this bone metastasis. Breast cancer can spread to bones; anastrazole can prevent the spread of certain breast cancers. Hope this helps. ...Read more

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Are breast cancer and bone cancer related?

Sort of: Breast cancer can spread to the bones; this is called metastasis. This is the closest relationship. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


Dr. John Geisler
244 doctors shared insights

Endometrial Cancer (Definition)

The endometrium is the lining of the inside of the uterus. Endometrial Cancer is cancer that starts in the cells of the endometrium and begins to spread to ...Read more