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Doctor insights on: Tamoxifen

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Dr. Sean Canale
638 Doctors shared insights

Tamoxifen (Overview)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer that does not spread.


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What exactly is tamoxifen therapy?

What exactly is tamoxifen therapy?

Anti-estrogen: Tamoxifen is a molecule that can attach to estrogen receptors (sticky hands on cells that like estrogen). If estrogen (female hormone) binds these receptors it typically causes growth/ turn cell on. Tamoxifen mimics estrogen but can have the opposite effect, hence anti-esteogen. Tamoxifen by attachment can turn cells off (in some breast cells) or turn cell on (in uterus).

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Dr. Sean Canale
638 Doctors shared insights

Tamoxifen (Overview)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer that does not spread.


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Is there an alernative to tamoxifen?

Is there an alernative to tamoxifen?

Yes: For breast cancer treatment, aroma taste inhibitors are often used in place of tamoxifen, only in post menopausal women.

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Please describe the medication: tamoxifen?

Please describe the medication: tamoxifen?

Tamoxifen: Treats advanced breast cancer in men and women, and early breast cancer in women. Also may prevent breast cancer in women who are at a high risk because of age, family history, or other factors.

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Which kind of doctor administers or prescribes tamoxifen?

Which kind of doctor administers or prescribes tamoxifen?

It Depends: It depends on what the tamoxifen is being used to treat. If used to treat breast cancer, it is mostly prescribed by an oncologist. However, tamoxifen can also be used as treatment for severe breast pain/fibrocystic disease, or for breast cancer prevention. In those cases a primary care physician, general surgeon, or gynecologist may prescribe it.

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My doc has prescribed tamoxifen and iui. Why?

My doc has prescribed tamoxifen and iui. Why?

Increases fertility: Tamoxifen will increase your fsh and lh wihich will increase your fertility. That increases the chances that your IUI will be successful. Be aware that if you are a woman, you will likely get some pretty nasty menopausal symptoms while you are taking taxmoxifen. Once you get pregnant, you need to stop taking it. Discuss all of this with your doctor!

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What is USP tamoxifen citrate commonly used for?

Endocrine therapy.: Tamoxifen is most commonly prescribed for the treatment of estrogen receptor-positive breast cancer, typically in women diagnosed prior to menopause. It may also be used to prevent breast cancer in high-risk patients. Following menopause, a class of drugs very similar to tamoxifen, called aromatase inhibitors, are preferentially used for breast cancer treatment rather than tamoxifen.

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Is there an effective substitue for tamoxifen as post cancer treatment?

Is there an effective substitue for tamoxifen as post cancer treatment?

Yes: Depending on the menopausal status other drugs can be used. For premenopausal women toermifine can be used if necessary. In postmenopausal women aromatase inhibiotrs such as anastrozole, letrozole, etc can be used.

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How does tamoxifen actually work?

How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow.

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Is it safe to take tamoxifen every other day?

Is it safe to take tamoxifen every other day?

Speak to your doctor: This is not the usual regimen for tamoxifen. It is usually recommended for daily use and intake for the best effect. Was this recommended by your doctor? If so, you need to find out why this deviates from the standard recommendation. If you are making up your own regimen, please do not proceed until you speak with your physician.

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I have been taking Tamoxifen 50mg for 2 months and have developed severe sciatic nerve pain. What can I do alleviate pain & is med causing side effect?

I have been taking Tamoxifen 50mg for 2 months and have developed severe sciatic nerve pain. What can I do alleviate pain & is med causing side effect?

Sciatica: Sciatic nerve pain is not one of the side-effects of Tamoxifen. The most common cause of sciatic nerve pain is a pinched nerve due to a herniated lumbar disc. However, breast cancer can spread to the spine and cause sciatic nerve pain. An MRI of the lumbar spine is indicated to evaluate the pain. See a spine specialist to evaluate the sciatica.

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How can I minimize the side effects of tamoxifen?

Talk with your doc: There are means for dealing with menopausal symptoms/hot flashes. Soy use is controversial but some antidepressants can help but be careful as some also inhibit tamoxifen metabolism. Effexor/venlefaxine is the most studied and does not do this. There are some patients who have achieved great relief with alternative therapies such as accupuncture.

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I've been taking Adderall for 10 years (30 mg 2xday). What are the long-term effects of central nervous system stimulants? #nqlu I'm 57 & in addition to adderall, take Zoloft (50 mg), Armour Thyroid (90 mg), bystolic (10 mg), and tamoxifen (20 mg).

I've been taking Adderall for 10 years (30 mg 2xday). What are the long-term effects of central nervous system stimulants? #nqlu I'm 57 & in addition to adderall, take Zoloft (50 mg), Armour Thyroid (90 mg), bystolic (10 mg), and tamoxifen (20 mg).

Usually not many: Some doctors recommend having "holidays" from stimulants, for times when not having the best concentration and focus might not matter as much - like weekends, vacations etc. There is little or no evidence that long-term medicinal stimulants taken as prescribed cause any significant damage to the cns, although sleep disturbance/anxiety and hopelessness (depression) may be related. Talk to your doc.

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I am taking tamoxifen 20 mg per day for the last 5 years I have noticed recently I bruise quite easily is this a side effect of the pills?

I am taking tamoxifen 20 mg per day for the last 5 years I have noticed recently I bruise quite easily is this a side effect of the pills?

Bruising tamoxifen: Tamoxifen can increase bruising due to affect on your plateletsmake sure you discuss with physcian prescribing tamoxifen he can check you for this.

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What are the long term side effects of a 55 yo man using tamoxifen? No history of blood clots, on lovaza 4g/day. I have no obvious symptoms from taking it.

Hmm...off-label use?: Tamoxifen is fda-approved for use in breast cancer, most commonly in women. So all the known side effects are described for women, not men. Check out www. Epocrates. Com & www. Drugs. Com for info on any given drug, tamoxifen included. The list of potential side effects is pretty long so you want to be sure that you really need this medication and that desired benefit exceeds potential risk.

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I'm taking tamoxifen and am an avid runner. (currently training for a half marathon). Just recently I have been having pain in my right hip area. What is the diff. Between bone and muscle pain?

I'm taking tamoxifen and am an avid runner. (currently training for a half marathon). Just recently I have been having pain in my right hip area. What is the diff. Between bone and muscle pain?

Bone vs. Muscle pain: Muscle pain is far more common. It tends to cause pain during or after activity & is more likely to be affected by position. Bone pain feels deeper, more severe & may be constant. Tamoxifen can cause bone, joint or muscle pain. It is usually generalized or symmetric rather than just one joint. Runners can get bursitis or iliotibial band symptoms. Call your doctor if your symptoms worsen.

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