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Doctor insights on: Taking Methotrexate And Hydroxychloroquine

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Better to be on methotrexate and hydroxychloroquine or methotrexate and a biologic when treating jra? Methotrexate only doesn't help

Better to be on methotrexate and hydroxychloroquine or methotrexate and a biologic when treating jra? Methotrexate only doesn't help

Depends on severity: Since you have already been on Methotrexate and its not helping you get complete relief from symptoms, further addition of therapies will depend on severity of your current symptoms. Hydroxychloroquine is milder in efficacy as compared to biologics & both have different side effect profiles. Talk to a rheumatologist who can assess your clinical course & treatment needs & then advise accordingly. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What is the blood work protocol while taking hydroxychloroquine and methotrexate? I've had bloodwrk once in the year i've been taking these 2 drugs.

What is the blood work protocol while taking hydroxychloroquine and methotrexate? I've had bloodwrk once in the year i've been taking these 2 drugs.

Tests: Blood tests for monitoring of methtrexate consist of CBC and platelet count as well as liver function tests to keep track of potential liver and bone marrow damage. The tests can be done every 3 to 6 months or as needed as determined by any symptoms. Plaquenil (hydroxychloroquine) rarely causes blood problems but an annual eye exam is important. ...Read more

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How common is it to use both methotrexate and hydroxychloroquine in treating juvenile arthritis? Is this safe? What should I know before starting?

How common is it to use both  methotrexate and hydroxychloroquine in treating juvenile arthritis? Is this safe? What should I know before starting?

JiA treatment: For multi-drug therapy for jia, Methotrexate is more commonly paired with biologic medication. For methotrexate, watch for mouth sores and nausea. Blood testing will be needed to check blood counts and liver tests. For treatment with plaquenil, (hydroxychloroquine) plan to have annual eye exams. ...Read more

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Is oral nac effective? Will taking oral nac (n-acetylcysteine) interfere with either methotrexate or plaquenil (hydroxychloroquine)?

NAC : I assume you are taking mtx and plaquinil for their anti-inflammatory effects for psoriasis? This combination is also used for a variety of other systemic diseases, too. Nac has been touted by naturopaths as an effective supplement to ward off some of the side effects of the drug therapy, but some people have experienced life threatening results, especially diabetics. Check with your doctor first! ...Read more

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Is it common practice to wean off plaquenil (hydroxychloroquine) for undifferentiated connective tissue disease if it didn't improve sx?Methotrexate was added & helps.

Is it common practice to wean off plaquenil (hydroxychloroquine) for   undifferentiated connective tissue disease if it didn't improve sx?Methotrexate was added & helps.

Yes: With any condition treated if a medication did not work it makes no sense to stay on it. Methotrexate is very commonly used and can be very effective as it appears to be with you. ...Read more

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