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Doctor insights on: Taking Methotrexate And Having Wrong Site Surgery

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Why do I need to stop methotrexate & arava (leflunomide) before alif surgery? I can't take it for 2 months after, why?

See details: Two months is an unusually long period to hold Methotrexate after surgery. Three weeks is more the usual but it is ultimately up to your surgeon. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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My mom has RA will undergo in this two weeks hip replacment surgery..so she should stop taking adalimumab(humira) and methotrexate for surgery ?

My mom has RA will undergo in this two weeks hip replacment surgery..so she should stop taking adalimumab(humira) and methotrexate for surgery ?

Probably yes: The operating surgeon will direct you in the correct answer. These medicines may change immune system or risk of bleeding, but only the surgeon has the experience to direct your mom for best outcome. When to stoop and restart is crucial to allow the meds to continue controlling the underlying disease. ...Read more

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Treatment for a cervical pregnancy, just took third shot of methotrexate. If hCG numbers don't go down by tuesday they want to do surgery. Hcg 1660?

Treatment for a cervical pregnancy, just took third shot of methotrexate.  If hCG numbers don't go down by tuesday they want to do surgery. Hcg 1660?

Ectopic/cervical: You have a rare type of ectopic pregnancy which the md is using a first line of rx with Methotrexate in less than 8 weeks of gestation hopefully. If the HCG is still elevated the surgery is necessary to remove the pregnancy before it ruptures in the cervix through the uterine or descending vaginal artery. ...Read more

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Why is the injection site yellow after taking methotrexate? It looks like someone colored it with a high lighter

Why is the injection site yellow after taking methotrexate? It looks like someone colored it with a high lighter

Bruise by injection: Bruise from injection may change color due to the breakdown of hemoglobin from red blood cells in extracellular space. Colors of a bruise are caused by sequential degradation of hemoglobin to biliverdin to bilirubin to hemosiderin, with hemoglobin itself producing red-blue color, biliverdin producing green color, bilirubin producing yellow color. ...Read more

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While taking methotrexate is there any foods I should avoid, for example grapefruit?

Also, milk rich food: If you take oral Methotrexate (tablets) along with milk or milk-rich foods, it may decrease absorption. This is not toxic but may result in getting a lower dose than you need to keep your disease under control. This can be avoided by taking injections under the skin of Methotrexate which are not painful and you can guarantee 100% absorption. As you probably know, always avoid any alcohol. ...Read more

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Can i take cold medication if i'm taking methotrexate. ?

See below: As a good rule of thumb, if you have an infection, you would want to leave off your Methotrexate and Imuran (azathioprine) and when the infection resolves, you can resume them. ...Read more

Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more