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Doctor insights on: T Cell Receptor Gene Rearrangement

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Explain what happens when the antigen binds with t cell receptor?

Explain what happens when the antigen binds with t cell receptor?

T cell activation: In most cases, antigen must be "shown" to the t cell receptor along with a protein called mhc. If the cell with the antigen/mhc also has the proper co-stimulatory proteins, the t cell is activated (like needing 2 keys to fire a missle). If the extra proteins are not present, the t cell may cease to function. If the t cell was already activated, it can produce chemicals and/or kill the other cell. ...Read more

Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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Explain what happens when the antigen binds with t cell receptor?

T cell activation: In most cases, antigen must be "shown" to the t cell receptor along with a protein called mhc. If the cell with the antigen/mhc also has the proper co-stimulatory proteins, the t cell is activated (like needing 2 keys to fire a missle). If the extra proteins are not present, the t cell may cease to function. If the t cell was already activated, it can produce chemicals and/or kill the other cell. ...Read more

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Living with Sickle Cell Disease (Checklist)

Keep doctor's appointments
Once
Go to lab appointments
Once
Keep oxygen up by maintaining low weight, no smoking
Once
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Cause of chronic elevated T cell counts with a monoclonal T cell beta gene rearrangement. Bouts of itching reddened skin. Some LGL's noted Normal CBC?

Cause of chronic elevated T cell counts with a monoclonal T cell beta gene rearrangement. Bouts of itching reddened skin. Some LGL's noted Normal CBC?

See dermatologist: How do you know the monoclonal T cell status? This suggests mycosis fungoides. I recommend that you see a dermatologist. ...Read more

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What would b the cause of chronic high T cell counts, cd4, 5, 7, and 8. A T-cell beta gene rearrangement, elevated IGG, elevated LGL's, but normal CBC?

What would b the cause of chronic high T cell counts, cd4, 5, 7, and 8. A T-cell beta gene rearrangement, elevated IGG, elevated LGL's, but normal CBC?

Reason for doing it: What was the reason you got this done. In all patients we don't do T cell count, Immunoglobulin level estimation etc. What were your symptoms. Based on your answerc an give a better explanation. In any patient we do CBC- complete blood count with differential count.Only in people with suspected immunodeficiencies/hematological problems-dyscrasias is the term we use, detailed Tcell,B cell ,Ig done ...Read more

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Cause of a positive monoclonal T cell beta gene rearrangement?

Cause of a positive monoclonal T cell beta gene rearrangement?

Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more

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What is the signifigance of a mono clonal T cell beta gene rearrangement found in blood ? All other labs are normal. Is this a sign of lymphoma ?

What is the signifigance of a mono clonal T cell beta gene rearrangement found in blood ? All other labs are normal. Is this a sign of lymphoma ?

Probably not: Monoclonal populations of immune cells can be a challenge to diagnose. Conditions like RA can associate with t-cell monoclonal populations. If the counts are otherwise normal, the group of cells should be followed but probably do not represent malignancy per se, though technically are a "neoplastic" proliferation of cells. http://www.ncbi.nlm.nih.gov/pubmed/18474096 Check with your doctor. ...Read more

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A T cell beta monoclonal gene rearrangement was found in my blood. I've also had some rashing / hives on the skin, with bad Itching. CBC & CMP normal ?

A T cell beta monoclonal gene rearrangement was found in my blood. I've also had some rashing / hives on the skin, with bad Itching. CBC & CMP normal ?

TCR beta: Monoclonal TCR beta can be seen with autoimmune diseases; this means that a certain specific type of T cell -- the one causing the skin issues, most likely -- has grown to be a disproportionately large percent of your total T cells. This can usually be treated with immune suppression. You should probably have the skin biopsied and see a dermatologist at a medical school to rule out more serious dz ...Read more

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Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?

Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?

?: Can still be chronic idiopathic urticaria, but other lab tests need to be performed as well: thyroid function tests, thyroid antibodies, complement levels, stools analysis, etc.. also other pieces of history need to be known, better see an allergist, check aaaai.org or acaai.org for an allergist in your area, meanwhile keep taking whatever antihistaminic on regulat basis, good luck ...Read more

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What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

No simple answer.: t-cell receptor studies prove clonality, meaning an expansion of a single line of T-cells, a kind of immune system cell. The test is mainly used to confirm the presence of T-cell cancers, but is not sufficient for cancer diagnosis because it's too sensitive and not specific. Anything that stimulates the immune system, infections, autoimmune diseases, inflammatory states, will produce a positive. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more