Top
15
Doctor insights on: T Cell Receptor Gene Rearrangement

Share
1

1
Explain what happens when the antigen binds with t cell receptor?

Explain what happens when the antigen binds with t cell receptor?

T cell activation: In most cases, antigen must be "shown" to the t cell receptor along with a protein called mhc. If the cell with the antigen/mhc also has the proper co-stimulatory proteins, the t cell is activated (like needing 2 keys to fire a missle). If the extra proteins are not present, the t cell may cease to function. If the t cell was already activated, it can produce chemicals and/or kill the other cell. ...Read more

Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


2

2
Explain what happens when the antigen binds with t cell receptor?

T cell activation: In most cases, antigen must be "shown" to the t cell receptor along with a protein called mhc. If the cell with the antigen/mhc also has the proper co-stimulatory proteins, the t cell is activated (like needing 2 keys to fire a missle). If the extra proteins are not present, the t cell may cease to function. If the t cell was already activated, it can produce chemicals and/or kill the other cell. ...Read more

3

3
Living with Sickle Cell Disease (Checklist)

Keep doctor's appointments
Once
Go to lab appointments
Once
Keep oxygen up by maintaining low weight, no smoking
Once
4

4
What would b the cause of chronic high T cell counts, cd4, 5, 7, and 8. A T-cell beta gene rearrangement, elevated IGG, elevated LGL's, but normal CBC?

What would b the cause of chronic high T cell counts, cd4, 5, 7, and 8. A T-cell beta gene rearrangement, elevated IGG, elevated LGL's, but normal CBC?

Reason for doing it: What was the reason you got this done. In all patients we don't do T cell count, Immunoglobulin level estimation etc. What were your symptoms. Based on your answerc an give a better explanation. In any patient we do CBC- complete blood count with differential count.Only in people with suspected immunodeficiencies/hematological problems-dyscrasias is the term we use, detailed Tcell,B cell ,Ig done ...Read more

5

5
Cause of a positive monoclonal T cell beta gene rearrangement?

Cause of a positive monoclonal T cell beta gene rearrangement?

Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more

6

6
What is the signifigance of a mono clonal T cell beta gene rearrangement found in blood ? All other labs are normal. Is this a sign of lymphoma ?

What is the signifigance of a mono clonal T cell beta gene rearrangement found in blood ? All other labs are normal. Is this a sign of lymphoma ?

Probably not: Monoclonal populations of immune cells can be a challenge to diagnose. Conditions like RA can associate with t-cell monoclonal populations. If the counts are otherwise normal, the group of cells should be followed but probably do not represent malignancy per se, though technically are a "neoplastic" proliferation of cells. http://www.ncbi.nlm.nih.gov/pubmed/18474096 Check with your doctor. ...Read more

7

7
Cause of chronic elevated T cell counts with a monoclonal T cell beta gene rearrangement. Bouts of itching reddened skin. Some LGL's noted Normal CBC?

Cause of chronic elevated T cell counts with a monoclonal T cell beta gene rearrangement. Bouts of itching reddened skin. Some LGL's noted Normal CBC?

See dermatologist: How do you know the monoclonal T cell status? This suggests mycosis fungoides. I recommend that you see a dermatologist. ...Read more

8

8
A T cell beta monoclonal gene rearrangement was found in my blood. I've also had some rashing / hives on the skin, with bad Itching. CBC & CMP normal ?

A T cell beta monoclonal gene rearrangement was found in my blood. I've also had some rashing / hives on the skin, with bad Itching. CBC & CMP normal ?

TCR beta: Monoclonal TCR beta can be seen with autoimmune diseases; this means that a certain specific type of T cell -- the one causing the skin issues, most likely -- has grown to be a disproportionately large percent of your total T cells. This can usually be treated with immune suppression. You should probably have the skin biopsied and see a dermatologist at a medical school to rule out more serious dz ...Read more

9

9
Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?

Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?

?: Can still be chronic idiopathic urticaria, but other lab tests need to be performed as well: thyroid function tests, thyroid antibodies, complement levels, stools analysis, etc.. also other pieces of history need to be known, better see an allergist, check aaaai.org or acaai.org for an allergist in your area, meanwhile keep taking whatever antihistaminic on regulat basis, good luck ...Read more

10

10
What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

No simple answer.: t-cell receptor studies prove clonality, meaning an expansion of a single line of T-cells, a kind of immune system cell. The test is mainly used to confirm the presence of T-cell cancers, but is not sufficient for cancer diagnosis because it's too sensitive and not specific. Anything that stimulates the immune system, infections, autoimmune diseases, inflammatory states, will produce a positive. ...Read more

11

11
R there specific receptor genes more common in "smokers" NSCLC that can be tested to determine possibility of target therapy? Read EGF + ALK unlikely

R there specific receptor genes more common in "smokers" NSCLC that can be tested to determine possibility of target therapy? Read EGF + ALK unlikely

Yes and no.: Non small cell lung cancer (NSCLC) is more common in smokers than non-smokers. Mutations in EGFR, ALK, ROS1 can be found in both, although ALK occurs more often in non-smokers, particularly young Asian women. EGFR and ALK mutations respond to different therapies than non-mutated cancers. ...Read more

12

12
Which viruses and/or bacteria, if any, are known to affect and/or mutate the vdr gene ( vitamin d receptor gene)?

Which viruses and/or bacteria, if any, are known to affect and/or mutate the vdr gene ( vitamin d receptor gene)?

Deficiencies in gene: Due 2 infection are unlikely the cause of poor vit d function, it's usually vit d deficiency, lack of sunlight. Not sure, it's low probability. Other symptoms may get relief if u sleep better at night w/better daytime energy. It's not hard with the proper meds. I bet your memory due 2 anxiety/ mood issue. The meds can b tailored to help pain, must sleep for pain control. Private for med review? ...Read more

13

13
Does cardiology office do LDL receptor gene mutation screening? If not, where can it be done? Does insurance cover cost? What's the cost if self pay?

Does cardiology office do LDL receptor gene mutation screening? If not, where can it be done? Does insurance cover cost? What's the cost if self pay?

Possibly: Certainly, a cardiologist's office can help facilitate testing. Coverage for testing is variable and you would need to consult your insurer. ...Read more

See 2 more doctor answers
14

14
Can you tell me is NMDA receptor encephalitis a genetic disorder?

Can you tell me is NMDA receptor encephalitis a genetic disorder?

No, autoimmune: Nmda receptor encephalitis is an autoimmune disorder in which the immune system gets sensitized to an antigen which closely matches the normal nmda receptors and then attacks the brain cells which have those receptors. Often this is triggered by a cancer, a so-called "paraneoplastic syndrome"; this is not a genetic disorder. ...Read more

15

15
Can you tell me in receptor-aided endocytosis, what particles are taken into the cell?

Can you tell me in receptor-aided endocytosis, what particles are taken into the cell?

A large number: Usually two receptors are bound by the ligand that causes conformational change resulting in endocytosis. This is a common mechanism for sending signals from cell surface to the interior. Growth factors, hormones, antibodies etc all work in this way. Endocytosis is not essential, as conformational change of the receptor can transmit the signal without the receptor being internalized. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more