Doctor insights on:
T Boz Sickle Cell Anemia
Fetal hemoglobin: Sickle cell disease results from a mutation in the beta hemoglobin gene. In infants, the beta hemoglobin gene is largely not used by the body (the gene is "off"). Instead, babies use a different gene named gamma hemoglobin. The gamma hemoglobin does not carry the sickle mutation. During the 1st year of life, the body gradually switches from using gamma to beta. Thus, symptoms can be delayed. ...Read more
Inherited: Sickle cell anemia is hereditary. But it comes in several varieties depending what was inherited from parents. S-s is severe & usually diagnosed in infancy. S-a is carrier state & may go undetected into adulthood. Many variants are possible. This refers to how hemoglobin proteins are manufactured by red cells programmed by genes. See: http://ghr.Nlm.Nih.Gov/condition/sickle-cell-disease. ...Read more
I'm having a tough time with my sickle cell anemia. I'm hurting everyday. I don't know what to do.
How come clinical signs in sickle cell anemia don't appear until the child is at least 12 months old?
Only here in the US: If you compare a MAP of malaria prevalence (number of cases) to a MAP of sickle cell disease prevalence, they are almost super-imposable with one exception; the United States. The prevalence of sickle cell anemia in the us is as high as some african countries with lower malaria frequencies, but our only malaria comes from travelers. ...Read more
If my boyfriend has sickle cell anemia and I don't have neither the trait or disease, will our child end up having it?
No: If your boyfriend has sickle cell anemia (2 abnormal genes) and you have 2 normal genes, then your children will all have sickle cell trait but none will have the disease. You need to be sure you have no other blood abnormalities like thalassemia or hemoglobin c trait which can be totally asymptomatic; this would change the answer significantly! ...Read more
Can you grow into sickle cell anemia?If you have the trait can you have it wen your younger but it doesn't show until it gets older?
More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more
Who will have it bad: The trend currently is trying to find out why some people have very little problems and others can be so troubled by this disease. In some, the disease will cause strokes, lung problems, leg ulcers etc. If we knew early on who would have it bad, maybe treatments could be given earlier to prevent these problems. But not everyone has it bad, so it is hard to know. ...Read more
See below: Sickle cell anemia occurs when 2 abnormal hemoglobin genes are present and a person's body produces sickle cell hemoglobin exclusively. 1 sickle cell gene and a normal gene produce sickle trait, which has no symptoms. Other abnormal hemoglobin genes can combine with a sickle cell gene and produce other types of anemia. There are several other genetic hemoglobin abnormalities. ...Read more
Anemia, pain, crises:
The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others.
Most patients that have sickle cell trait are completely asymptomatic. ...Read more
Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more
Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more
No: Sickle cell disease occurs when you inherit sickle genes from both parents. The parents are usually unaffected because they have at least one normal gene that does the work for two. When you have 2 defective genes, the work is not done and you have sickle cell disease. You don't catch it like a germ or develop it as a reaction to something. ...Read more