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Doctor insights on: T Boz Sickle Cell

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Dr. James Ball
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Sickle Cell Disease (Definition)

An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more


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I have sickle cell anemia trait can that affect me?

I have sickle cell anemia trait can that affect me?

Usually not: Sickle cell trait is a hemoglobin genotype as and is generally regarded as a benign condition. However, individuals with sickle cell trait may have rare complications that mimic sickle cell disease. ...Read more

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Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more

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Can I have sickle cell anemia?

Can I have sickle cell anemia?

Anyone can...: It would be unlikely that would could reach the age of 46 and not be diagnosed with sickle cell anemia. If you are truly concerned, testing is very easy. ...Read more

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How do you test fetus for sickle cell anemia?

Genetic test Sickle: Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents. ...Read more

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How do people treat sickle cell anemia to prevent sickle cells?

How do people treat sickle cell anemia to prevent sickle cells?

Sickle cell Dz Rx: Several things may be helpful. Supportive measures include staying hydrated and eating a balanced diet. Some physicians recommend folate (folic acid) supplementation due to rapid rbc turnover. Antibiotic prophylaxis is recommended in children but can often be stopped in late childhood as instructed by your doctor. Regular care in a comprehensive center. Hydroxyurea can be beneficial by raising hgbf levels. ...Read more

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What make sickle cell patients lean?

What make sickle cell patients lean?

Not all patients....: With sickle cell disease are lean, but most are. There are several reasons, and many things we don't know. First, the half life of sickle red cells is much shorter than for normal rbcs. Thus pts must make red cells much more often, which requires energy. Also, caloric intake for sickle cell pts is less than required at quiescence and falls during crises and hospitalization. Many other factors 2. ...Read more

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Can we use hydroxyurea with sickle cell anemia patient?

Can we use hydroxyurea with sickle cell anemia patient?

HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read more

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Help docs, is hemoglobin AC a sickle cell trait?

Help docs, is hemoglobin AC a sickle cell trait?

No: Hgb AC is a heterozygous genetic state that is not sickle cell trait ( Hgb AS). Patient's with Hgb AC are clinically well with at worst mild asymptomatic anemia (most are not anemic). Individuals with Hgb AC can have children with Hgb SC (a type of severe sickle cell hemoglobinopathy) if their partner has either sickle cell trait (25% chance) or sickle cell disease (50% chance) ...Read more

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My baby have hb e/beta thalassemia? Is it sickle cell disease?

My baby have hb e/beta thalassemia? Is it sickle cell disease?

No: It is not sickle cell disease. It is a "hemoglobinopathy" or genetic disorder of hemoglobin...And it can cause anemia. Sickle cell has malformed red blood cells that become "sickle" shaped and can get stuck in organs and vessels and cause pain. E/beta thalassemia is different. ...Read more

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How did sickle cell anemia relate to malaria?

How did sickle cell anemia relate to malaria?

Malaria /sickle cell: In a person who has sickle-cell trait, the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.” S ...Read more

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What makes sickle cell anemia so significant?

Chronic disease: Sickle cell disease is so significant in that it is a chronic disease that affects almost every organ. Like diabetes, the effects of sickle cell, crises, and transfusions can permanently affect the heart, the kidneys, the liver, the lungs, and the brain. ...Read more

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If me and boyfriend both have sickle cell trait, how will we prevent our children from having full sickle cell anemia?

If me and boyfriend both have sickle cell trait, how will we prevent our children from having full sickle cell anemia?

Nothing: Unfortunately, there would be 25% chance for your child to have sickle cell disease and 50% chance for sickle cell trait . With our technology now, nothing can alter the risk. Sorry to say , the only thing for somebody with sickle cell trait to completely prevent any possibility of having a biological child with sickle cell disease is by having a child with somebody with normal hb. ...Read more

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What exactly does sickle cell trait do to me ? And if I have the sickle cell trait but I am anemia (anemic) what's the difference.

What exactly does sickle cell trait do to me ? And if I have the sickle cell trait but I am anemia (anemic) what's the difference.

Discuss With Doctor: Sickle Cell Trait (SCT); is genetic carrier state for Sickle Cell Disease. In SCT: 1 hemoglobin(Hg) is normal, other is sickle; anemia does not occur. However other abnormal Hg's exist & one can inherit sickle Hg from 1 parent with for example Thalassemia Hg from other parent. In this case mild anemia can occur with "SCT". People with SCT can have anemia not related to Hg too. Discuss with doctor. ...Read more

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Can you please tell me how sickle cell disase and sickle cell anemia differ?

Can you please tell me how sickle cell disase and sickle cell anemia differ?

It depends: This often gets confusing because doctors don't always use terms the same way. Sickle cell anemia typically refers to the condition where a person inherits two s genes; by convention hematologists call this ss. This is also a type of sickle cell disease, but often hematologist include other diseases like sc disease (one s gene, one c gene) or s/beta thal under the umbrella of sickle cell disease. ...Read more

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Are malaria and sickle cell anemia related? If so, how?

Are malaria and sickle cell anemia related? If so, how?

Yes: The mutation in sickle cell disease causes the red blood cell half-life to be shorter than normal. This can offer some protection against malaria because it disrupts the life cycle of the organism. This disease, along with thalassemias (which also shorten the red blood cell half-life), are prevalent in areas of the world that have high malaria rates. ...Read more

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How does exchange transfusion benefit sickle cell patients?

How does exchange transfusion benefit sickle cell patients?

Removes sickle cells: Acute red cell exchange is useful in acute infarctive stroke, in acute chest and multi-organ failure syndromes. The process replaces sickled red blood cells with normal red blood cells. This procedure can also benefit certain patients on chronic transfusion plans by replacing sickled cells without increasing the viscosity of blood. ...Read more

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What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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What are helper T cells, killer T cells, and B cells?

What are helper T cells, killer T cells, and B cells?

Lymphocytes: Part of white blood cells, there are different types of lymphocytes, all look alike under the microscope, their functions differ, as their names imply, helper T cells orchestrate most of the immune system functions,killer T cells,are one of the first lines of body defence against invading microorganisms,and B cells' main function is to produce antibodies against microbes with the help of T cells ...Read more

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How come clinical signs in sickle cell anemia don't appear until the child is a year old?

How come clinical signs in sickle cell anemia don't appear until the child is a year old?

Fetal hemoglobin: Sickle cell disease results from a mutation in the beta hemoglobin gene. In infants, the beta hemoglobin gene is largely not used by the body (the gene is "off"). Instead, babies use a different gene named gamma hemoglobin. The gamma hemoglobin does not carry the sickle mutation. During the 1st year of life, the body gradually switches from using gamma to beta. Thus, symptoms can be delayed. ...Read more

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Can you get sickle cell anemia as an adult, but didn't have it as a child or is it a hereditary?

Can you get sickle cell anemia as an adult, but didn't have it as a child or is it a hereditary?

Inherited: Sickle cell anemia is hereditary. But it comes in several varieties depending what was inherited from parents. S-s is severe & usually diagnosed in infancy. S-a is carrier state & may go undetected into adulthood. Many variants are possible. This refers to how hemoglobin proteins are manufactured by red cells programmed by genes. See: http://ghr.Nlm.Nih.Gov/condition/sickle-cell-disease. ...Read more

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I'm having a tough time with my sickle cell anemia. I'm hurting everyday. I don't know what to do.

I'm having a tough time with my sickle cell anemia. I'm hurting everyday. I don't know what to do.

Sickle cell anemia: What you need to do is see your hematology specialist as soon as you can. If you are not satisfied with this doctor ask your family or friends to tell you which other doctor they think is better. Please keep me informed. ...Read more

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How come clinical signs in sickle cell anemia don't appear until the child is at least 12 months old?

How come clinical signs in sickle cell anemia don't appear until the child is at least 12 months old?

Maturing hemoglobin: The hemoglobin involved with sickle cell develops after birth. Children are born with a different hemoglobin type and this changes over the first 3-6 months to be sickle hemoglobin. This is what delays the syptoms of sickle cell. ...Read more

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What is sickle cell anemia?

What is sickle cell anemia?

Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capillaries. Blocked circulation causes extreme pain in joints, abdomen, or chest. ...Read more

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What is the trend in sickle cell anemia?

Who will have it bad: The trend currently is trying to find out why some people have very little problems and others can be so troubled by this disease. In some, the disease will cause strokes, lung problems, leg ulcers etc. If we knew early on who would have it bad, maybe treatments could be given earlier to prevent these problems. But not everyone has it bad, so it is hard to know. ...Read more

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What are the effects of sickle cell anemia?

Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more

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Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

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Can I have sickle cell anemia?

Anyone can...: It would be unlikely that would could reach the age of 46 and not be diagnosed with sickle cell anemia. If you are truly concerned, testing is very easy. ...Read more

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How common is sickle cell anemia?

How common is sickle cell anemia?

Pretty common.: 1 in every 500 african-americans, and 1 in every 900 hispanic americans. ...Read more

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Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Why is sickle cell anemia painful?

Why is sickle cell anemia painful?

Poor circulation: In sickle cell disease red cell stick together and block circulation to extremity and other organ so it cause pain crisis. ...Read more

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How is sickle cell anemia detected?

Blood test: Every newborn baby undergoes "newborn screening" test before they are released from hospital. Most of abnormal hemoglobins, e.g. Hemoglobin s in sickle cell disease, are detected. ...Read more

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How dangerous is sickle cell anemia?

More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more

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Is sickle cell anemia a severe condition?

Depends: It depends on the type of sickle cell disease a patient has, and how many attacks they get in a year and how severe those attacks are. ...Read more

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What to tell me about sickle cell anemia?

What to tell me about sickle cell anemia?

See below: Sickle cell anemia occurs when 2 abnormal hemoglobin genes are present and a person's body produces sickle cell hemoglobin exclusively. 1 sickle cell gene and a normal gene produce sickle trait, which has no symptoms. Other abnormal hemoglobin genes can combine with a sickle cell gene and produce other types of anemia. There are several other genetic hemoglobin abnormalities. ...Read more

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What are the tests for sickle cell anemia?

Hb electrophoresis: CBC and hemoglobin electrophoresis have to be done -at least- to make a diagnosis of sickle cell anemia. ...Read more

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What is the symptoms of sickle cell anemia?

Anemia, pain, crises: The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others. Most patients that have sickle cell trait are completely asymptomatic. ...Read more

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What kind of disorder is sickle cell anemia?

What kind of disorder is sickle cell anemia?

Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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What is the 'reverse' of sickle cell anemia?

What is the 'reverse' of sickle cell anemia?

None: Sicle cell anemia is an inherent disorder of the red blood cell. The reverse woould be normal blood cells. ...Read more