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Doctor insights on: Systemic Sclerosis Dermatosclerosis

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What are the initial symptoms of scleroderma/systemic sclerosis?

What are the initial symptoms of scleroderma/systemic sclerosis?

Raynaud's: Tight skin is characteristic but there can be a variety of other symptoms such as raynaud's whihc is usually the first symptom, shortness of breath, chest pain, trouble swallowing, other GI symptoms, etc. Each person with scleroderma has a different set of symptoms and different type of scleroderma involvement. ...Read more

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Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


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Do you ever diagnose systemic sclerosis sine scleroderma and if so, what are the the clinical signs and symptoms of this disease?

Extremely rare: Systemic sclerosis sine scleroderma is a fibrosing condition of the internal organs including the GI tract, pulmonary artery, and lungs, but lacking the skin features if scleroderma. Systemic sclerosis is a rare condition to begin with, and systemic sclerosis sine scleroderma accounts for <10% of patients. Diagnosis might include antibody tests or abnormal biopsy of affected internal tissues. ...Read more

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What are the tests for systemic sclerosis?

What are the tests for systemic sclerosis?

Biopsy, blood: In advanced stages, no test is required. It if the diagnosis is suspected early, a skin biopsy will usually prove the diagnosis. In the blood, the scl-70 and the anti-centromere antibody tests are the most helpful. Other tests may be positive. The above two blood tests often help differentiate the disease from other conditions. Other tests are used to evaluate but not diagnose the condition. ...Read more

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Will systemic sclerosis kill me?

Will systemic sclerosis kill me?

It can: Systemic sclerosis is a progressive disease. It can be fatal by causing heart failure, respiratory failure, and any number of other complications. ...Read more

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Do people with systemic sclerosis have a lot of pain?

Do people with systemic sclerosis have a lot of pain?

Usually not: The problem with scleroderma is more related to complications. If pain is from the raynaud's phenomenon, vasodilation therapy might solve it. ...Read more

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Can somebody tell, just by looking, if you have facial symptoms of systemic sclerosis?

Can somebody tell, just by looking, if you have facial symptoms of systemic sclerosis?

Sometimes: The skin around the face can be tight in patients with systemic sclerosis. The hands, face, and fingers are typically involved early and can be observed by someone with experience in patients with systemic sclerosis. ...Read more

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Is there treatment for systemic sclerosis?

Is there treatment for systemic sclerosis?

Not really: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

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What is systemic sclerosis?

What is systemic sclerosis?

Systemic sclerosis: An autoimmune disease characterized by thickening and loss of elasticity of the skin. It may have systemic manifestations as well such as trouble swallowing and acid reflux. ...Read more

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Does anyone know about systemic sclerosis?

Does anyone know about systemic sclerosis?

Much research,but: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

Dr. Eric Weisman
136 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis (also known as scleroderma), is a disease of the connective tissue, causing tightening and ...Read more


Systemic (Definition)

A condition that involves the whole body as compared to a part of the body. For example diabetes ...Read more