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Doctor insights on: Systemic Sclerosis

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Does anyone know about systemic sclerosis?

Does anyone know about systemic sclerosis?

Much research,but: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


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What were your initial symptoms of systemic sclerosis?

What were your initial symptoms of systemic sclerosis?

Raynaud's : Raynaud's 1st but other systems can be involved - skin tightening, each person is different and on occasion the skin can be normal. ...Read more

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Do you ever diagnose systemic sclerosis sine scleroderma and if so, what are the the clinical signs and symptoms of this disease?

Do you ever diagnose systemic sclerosis sine scleroderma and if so, what are the the clinical signs and symptoms of this disease?

Extremely rare: Systemic sclerosis sine scleroderma is a fibrosing condition of the internal organs including the GI tract, pulmonary artery, and lungs, but lacking the skin features if scleroderma. Systemic sclerosis is a rare condition to begin with, and systemic sclerosis sine scleroderma accounts for <10% of patients. Diagnosis might include antibody tests or abnormal biopsy of affected internal tissues. ...Read more

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What are the tests for systemic sclerosis?

What are the tests for systemic sclerosis?

Biopsy, blood: In advanced stages, no test is required. It if the diagnosis is suspected early, a skin biopsy will usually prove the diagnosis. In the blood, the scl-70 and the anti-centromere antibody tests are the most helpful. Other tests may be positive. The above two blood tests often help differentiate the disease from other conditions. Other tests are used to evaluate but not diagnose the condition. ...Read more

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Is there treatment for systemic sclerosis?

Is there treatment for systemic sclerosis?

Not really: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

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Will systemic sclerosis kill me if I don't get treatment? Is it just a slow disease?

Will systemic sclerosis kill me if I don't get treatment? Is it just a slow disease?

Yes: Systemic sclerosis is a slow progressive but relentless disease. Current treatments are of limited efficacy. Having said that, you should follow closely with a rheumatologist. ...Read more

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My father was diagnosed with systemic sclerosis. Should I be worried for him?

Timely help is key: Systemic sclerosis remains a challenging disease in the field of rheumatology where struggle for a cure or even targeted therapy is ongoing. Most patients donot have adverse outcome but in case of lung and kidney involvement prognosis can be poor. There are many other areas of the body affected by it but they don't seem to be dangerous rather patient lifestyle and medication can help. ...Read more

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What is systemic sclerosis?

What is systemic sclerosis?

Systemic sclerosis: An autoimmune disease characterized by thickening and loss of elasticity of the skin. It may have systemic manifestations as well such as trouble swallowing and acid reflux. ...Read more

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Does anyone know about systemic sclerosis?

Much research,but: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

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What are the tests for systemic sclerosis?

Biopsy, blood: In advanced stages, no test is required. It if the diagnosis is suspected early, a skin biopsy will usually prove the diagnosis. In the blood, the scl-70 and the anti-centromere antibody tests are the most helpful. Other tests may be positive. The above two blood tests often help differentiate the disease from other conditions. Other tests are used to evaluate but not diagnose the condition. ...Read more

Systemic (Definition)

A condition that involves the whole body as compared to a part of the body. For example diabetes ...Read more


Dr. Pierre Moeser
177 doctors shared insights

Scleroderma (Definition)

Scleroderma is an autoimmune disease characterized by tightening of the skin on ...Read more