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Systemic Onset Juvenile Rheumatoid Arthritis
A condition where there is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more
How does systemic juvenile rheumatoid arthritis affect someone during adulthood if it is different from rheumatoid arthritis?
How does systemic juvenile rheumatoid arthritis affect someone during adulthood if it is different from adult ra?
Autoinflammatory dis: Systemic jia/jra is actually an autoinflammatory disease rather than an autoimmune disease and is more similar to periodic fever syndromes than RA or jra. There's a problem with the innate immune system's triggering and control of inflammation, not a problem with mistakenly recognizing one's own proteins as foreign (like a virus). As such, Anakinra and steroids are most effective long term meds. ...Read moreSee 1 more doctor answer
If with fever.: Some cases of jia (it is not RA in a child. We now call it juvenile idiopathic arthritis. In some with a variant called "still's disease, " hectic high fevers can occur. Vomiting is not uncommon with high fevers. Otherwise, if your child is not having fevers, it could be medication. Other issues are then probably present! ...Read moreSee 1 more doctor answer
Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?
SIRS + JRA = MAS?: There is controversy as to whether macrophage activating syndrome is a real entity, versus it being confused for hemophagocytic lymphohistiocytosis (hlh). Hlh has much more defined criteria and can make a patient very sick (and requires chemo for treatment). A question i would have is could a patient with jra who develops sirs really have hlh. I would consult peds hem/onc (rheum mds may disagree). ...Read moreSee 3 more doctor answers
Immune dysfunction!: Jra (also called jia) for juvenille idiopathic arthritis is a disease of unknown etiology. There are many theories for why it happens, many believe there is a virus responsible. The damage to the joints, pain and stiffness is due to an inappropriate immune response which results in the immune system attacking tissues of the host (patient). Rheumatologists can provide appropriate DX and rx. ...Read moreSee 2 more doctor answers
Autoimmune: Juvenile rheumatoid arthritis occurs when the immune system gets confused and starts attacking the joints instead of fighting intruders like bacteria and viruses. Genetic factors play a role in risk for developing autoimmune diseases. Exposure to certain viruses may play a role as well. ...Read moreSee 1 more doctor answer
Joint swelling >6wks: Jia/jra - general guide 1. Age of onset <16 yr 2. Arthritis (swelling or excess joint fluid), or 2 or more of these: less than full range of motion, tenderness or pain on motion, & increased warmth in at least 1 joint 3.Above signs (seen by doc)for > 6wks 4.Type seen in first 6 mo: a.Polyarthritis: ≥5 inflamed joints b.Oligoarthritis: 4 or fewer joints c.Systemic -fever, arthritis 5.No other cause. ...Read moreSee 1 more doctor answer
Many ways!: First, it is no longer called juvenile rheumatoid arthritis, but juvenile idiopathic arthritis, because it is not rheumatoid arthritis in children! there are so many treatments available, using several meds in tandem as therapy. It is almost always remittable. See a rheumatology specialist! ...Read moreSee 1 more doctor answer
Clinical criteria: Ra (also called jia) for juvenille idiopathic arthritis is a disease of unknown etiology. There are many theories for why it happens, many believe there is a virus responsible. Pain and stiffness may limit activity. Appropriate treatment can vastly benefit the patient, and a rheumatologist can be your best friend. Labs to rule out other causes are undertaken. Clinical criteria make the diagnosis. ...Read moreSee 1 more doctor answer
Varied ways: There are many types of juvenile arthritis. It can attack the joints with pain and swelling as most likely. There is a form that affects the spine with pain and stiffness. It may also affect the eyes with inflammation. A more severe form can also cause damage to internal organs including the spleen and affect the blood counts significantly. Need careful medical attention. ...Read moreSee 1 more doctor answer
Unlikely: The onset at age 49 is unlikely. Since you do not mention your symptoms, there is no way to definitively answer your question. ...Read more
Alleviating Sx?: Alleviating sx? Not the goal. Alleviating inflammation is the goal. Symptom relief is secondary in importance! the drugs used are similar for adults, except the doses are much lower and size-based. Jra no longer exist. It is juvenile idiopathic arthritis. Virtually all children should be remitted with currently available medication. ...Read moreSee 1 more doctor answer
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