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Doctor insights on: Systemic Onset Juvenile Rheumatoid Arthritis

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Can systemic juvenile rheumatoid arthritis cause you to get sick?

Can systemic juvenile rheumatoid arthritis cause you to get sick?

Yes: Systemic juvenile arthritis can cause diffuse body rash, recurrent fevers, multiple joint swellings and inflammation, as well as cause corneal changes of the eye resulting in vision loss. Systemic jra can also affect liver and kidney function. ...Read more

Dr. Thomas Namey
2,350 doctors shared insights

Arthritis (Definition)

Arthritis is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more


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How does systemic juvenile rheumatoid arthritis affect someone during adulthood if it is different from adult ra?

How does systemic juvenile rheumatoid arthritis affect someone during adulthood if it is different from adult ra?

Autoinflammatory dis: Systemic jia/jra is actually an autoinflammatory disease rather than an autoimmune disease and is more similar to periodic fever syndromes than RA or jra. There's a problem with the innate immune system's triggering and control of inflammation, not a problem with mistakenly recognizing one's own proteins as foreign (like a virus). As such, Anakinra and steroids are most effective long term meds. ...Read more

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Does systemic juvenile rheumatoid arthritis sometimes cause you to vomit?

Does systemic juvenile rheumatoid arthritis sometimes cause you to vomit?

If with fever.: Some cases of jia (it is not RA in a child. We now call it juvenile idiopathic arthritis. In some with a variant called "still's disease, " hectic high fevers can occur. Vomiting is not uncommon with high fevers. Otherwise, if your child is not having fevers, it could be medication. Other issues are then probably present! ...Read more

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Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?

Can systemic inflammatory response syndrome  in a 5 year old with juvenile rheumatoid  arthritis cause macrophage activation  syndrome?

SIRS + JRA = MAS?: There is controversy as to whether macrophage activating syndrome is a real entity, versus it being confused for hemophagocytic lymphohistiocytosis (hlh). Hlh has much more defined criteria and can make a patient very sick (and requires chemo for treatment). A question i would have is could a patient with jra who develops sirs really have hlh. I would consult peds hem/onc (rheum mds may disagree). ...Read more

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What is juvenile rheumatoid arthritis?

What is juvenile rheumatoid arthritis?

Immune dysfunction!: Jra (also called jia) for juvenille idiopathic arthritis is a disease of unknown etiology. There are many theories for why it happens, many believe there is a virus responsible. The damage to the joints, pain and stiffness is due to an inappropriate immune response which results in the immune system attacking tissues of the host (patient). Rheumatologists can provide appropriate DX and rx. ...Read more

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What causes juvenile rheumatoid arthritis?

Autoimmune: Juvenile rheumatoid arthritis occurs when the immune system gets confused and starts attacking the joints instead of fighting intruders like bacteria and viruses. Genetic factors play a role in risk for developing autoimmune diseases. Exposure to certain viruses may play a role as well. ...Read more

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Dr. Steven Griggs
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Rheumatism (Definition)

"rheumatism" is an older term, not used much today. Most people are referring to pain and swelling in the joints when they use this term. People may mean something different when they use this term in contrast to when they refer ...Read more


Dr. Robert Lowe
1,459 doctors shared insights

Painful Joints (Definition)

That term is not really a specific diagnosis, but rather somewhat of a general term. The medical term is arthralgias, which implies pain in multiple joint possibly coming from a single cause. Don't hesitate to be seen and evaluated for ...Read more