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Doctor insights on: Systemic Lupus Erythematosus Sle Anti Dna Antibodies Present

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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Dr. Melissa Haglund
11 doctors shared insights

Anti Dna Antibodies (Definition)

Briefly, anti dna antibodies are antinuclear antibodies that are used in the diagnosis of the autoimmune disease systemic lupus erythematosis, sle. There are antibodies against double stranded dna and single stranded dna. The former is useful in the case of sle. It is probably released from dying cells in a process that appears to be defective in this disease. This is ...Read more


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Is lupus erythematosus infectious?

Is lupus erythematosus infectious?

No: Is a immune based disease does not recognize self and attacks multiple organs. ...Read more

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Which percentage of diagnosed lupus cases are sle, systemic lupus erythmatosus?

Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read more

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What is trigger systemic lupus erythematosus in antiquity?

Mysterious lupus: It is not known what causes lupus erythematosus. Referring to antiquity, lupus was used to describe several different rashes. It could be autoimmune, where the body attacks itself such as lupus erythematosus or discoid lupus. It could be caused by tuberculosis infection such as lupus vulgaris. It could be related to another inflammatory disease such as sarcoidosis which causes lupus pernio. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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Is systemic lupus erythematosus fatal?

Sometimes.: Sle is generally treated with good response, but unfortunately it is sometimes fatal. ...Read more

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Systemic lupus erythematosus--what is sle?

Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?

Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more

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What gene causes lupus erythematosus?

What gene causes lupus erythematosus?

Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read more

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Is systemic lupus erythematous contagious?

Is  systemic lupus erythematous contagious?

No: It is an autoimmune disease in which your body produces antibodies against your own body cells leading to organ damages if left untreated. It is not contagious. ...Read more

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ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

Might be.: These labs do not rule lupus out nor do they rule it in. I think your doc should keep looking and monitor your progress over time. Depending upon joints could represent parvovirus although that is just a wild guess. Your clinical picture and progress is most important. ...Read more

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Ana positive strong family history of lupus. Lupus symptoms. Could it be sarcoidosis instead of lupus.

Maybe: ANA positive diseases are related. Diagnosis is based not just on serologic testing, but also on your clinical symptoms. You should be evaluated by a rheumatologist in order to receive an accurate diagnosis and then receive the most appropriate treatment. ...Read more

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Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more

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Are discoid lupus and sle different?

Are discoid lupus and sle different?

Yes: Discoid lupus is confined to the skin while systemic lupus can affect literally any organ of the body including the skin. ...Read more

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Does chronic cutaneous discoid lupus eryhermyosolus turn systemic if you have positive ANA 1:1280 normally.

Does chronic cutaneous discoid lupus eryhermyosolus turn systemic if you have positive ANA 1:1280 normally.

Cutaneous lupus: Systemic lupus erythematosus can follow the rash of discoid lupus, but a high titer ANA does not make that diagnosis without other specific signs and symptoms of systemic lupus ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more