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Doctor insights on: Sirs (Systemic Inflammatory Response Syndrome)

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Is SIRS (Systemic Inflammatory Response Syndrome) commonly associated with pain?

Is SIRS (Systemic Inflammatory Response Syndrome) commonly associated with pain?

Can be: Systemic Inflammatory Response Syndrome which is either fever or hypothermia,either high or low blood count with many WBC band forms, tachycardia and tachypnea, can be seen in infections with sepsis and in noninfectious insults such as trauma or burns. Therefore depending on the cause it can be associated with pain. ...Read more

Dr. Preeti Malani
273 doctors shared insights

Systemic Inflammatory Response Syndrome (Definition)

Systemic inflammatory response syndrome (SIRS) is a condition of inflammation throughout the body that can lead to failure of multiple organs. SIRS is typically caused by severe infections but can also be a result of other conditions like burns, ...Read more


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How does systemic inflammatory response syndrome trigger problems?

How does systemic inflammatory response syndrome trigger problems?

Inflammation bad!: Inflammation dose many things deleterious to the body including: releases inflammatory cytokines into the blood stream. This damages your blood vessels and accelerates atherosclerosis. Clotting factors rise, which are thrombotic themselves. The body enters a catabolic state (tiisue breakdown). People feel fatigued and bad. Inflammation from any cause need to treated. ...Read more

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Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?

Can systemic inflammatory response syndrome  in a 5 year old with juvenile rheumatoid  arthritis cause macrophage activation  syndrome?

SIRS + JRA = MAS?: There is controversy as to whether macrophage activating syndrome is a real entity, versus it being confused for hemophagocytic lymphohistiocytosis (hlh). Hlh has much more defined criteria and can make a patient very sick (and requires chemo for treatment). A question i would have is could a patient with jra who develops sirs really have hlh. I would consult peds hem/onc (rheum mds may disagree). ...Read more

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What are the tests for systemic inflammatory response syndrome (sirs)?

What are the tests for systemic inflammatory response syndrome (sirs)?

SIRS: The conference concluded that the manifestations of sirs include, but are not limited to: body temperature less than 36°c(96.8°f) or greater than 38°c(100.4°f) heart rate greater than 90 beats per minute tachypnea (high respiratory rate), with than 20 breaths per minute; or, an arterial partial pressure of carbon dioxide less than 4.3 kpa (32 mmhg) white blood cell count less than 4000 cells/mm³. ...Read more

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What is the treatment for systemic inflammatory response syndrome (sirs)?

SIRS: Sirs may result from a myriad of underlying causes. Treating the cause and supportive measures are the mainstay of the treatment. ...Read more

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I have vomiting episodes that lead to systemic inflammatory response syndrome without sepsis. What causes sirs? Insufficient cortisol from adrenals?

I have vomiting episodes that lead to systemic inflammatory response syndrome without sepsis.  What causes sirs?  Insufficient cortisol from adrenals?

Multifactorial: As a general rule, inflammatory conditions which produce the criteria necessary to term a condition sirs are induced by cytokine release, but there are many other possibilities. Generally not adrenal insufficiency. You seem to be trying to acquire a shorthand medical education. It is not that simple. ...Read more

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What is the difference between systemic inflammation and systemic inflammatory response syndrome?

What is the difference between systemic inflammation and systemic inflammatory response syndrome?

Definition: "systemic inflammation" is a generic term of inflammation in the body. The systemic inflammatory response syndrome, or sirs, is a particular reaction of the body after an infection (which is called sepsis) or trauma or other injury. The specific components of sirs are available to review online (simply "google" sirs). So, it's sort of similar but not exactly. Hope this helps! ...Read more

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Can SIRS (systemic inflammatory response syndrome) be an underlying cause of delirium or be otherwise associated with delirium?

Can SIRS (systemic inflammatory response syndrome) be an underlying cause of delirium or be otherwise associated with delirium?

Delirium: In critically ill patients, delirium is a frequent occurrence. Investigators have found that the profile of increased inflammatory biomarkers changes in critically ill patients with delirium according to the presence or absence of clinical evidence of inflammation (either infection or systemic inflammatory response syndrome). Thus, there is a reasonable associate between the two. ...Read more

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Dr. Norman Dy Dr. Dy
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Can systemic inflammatory response syndrome occur in the absence of infection?

Dr. Norman Dy Dr. Dy
1 doctor agreed:

Yes: Sirs represents an inflammatory response that has 'gone out of control, ' and is defined usually by vital signs abnorms and abn's in the blood count. Can occur with autoimmune problems, pancreatitis, burns, other physiological insults. If an infection is detected (with cultures, or clinically), then we refer to it as sepsis. Docs will sometimes use terms loosely, leading to some confusion. ...Read more

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Pro inflammatory mediators and pre inflammatory mediators differences ? Thank

Pro inflammatory mediators and pre inflammatory mediators differences ? Thank

Mediators: Inflammatory mediators are the signals that tell your white cells where to throw a punch at infection and then to punch it! The preinflammatory mediators are the cytokines (greek cell, move) interleukins and tumor necrosis factor. The punch comes from pro inflammatory mediators like leukotrienes. These are eicosanoids that produce the inflammation. They cause the tenderness and swelling. ...Read more

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With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?

With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?

SLE DPGN is bad.: The degree of remaining renal function dictates the inability of the kidney to excrete waste products and manage potassium levels. In any severe kidney disease when egfr approaches 15 ml/min uremia and elevated k+ levels are frequently noted. ...Read more

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Will A serious auto immune disease affecting the entire body cause elevated ESR & CRP ??

Not necessarily : These labs are unreliable in any case, and are only one small part of a work up. The real question is, "How do you feel?" A serious systemic autoimmune disease such as lupus, Wegener's, scleroderma or dermatitis iris has you suffering from obvious physical symptoms. ...Read more

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Which of the following are auto-immune conditions? Hypothyroidism Coeliac Disease Endometriosis Chronic Fatigue Syndrome (CFS)

Which of the following are auto-immune conditions? Hypothyroidism Coeliac Disease Endometriosis Chronic Fatigue Syndrome (CFS)

Comments: We are learning that the immune system is playing a huge role in many known diseases, and Celiac is certainly auto-immune mediated, and several thyroid disorders are too. Chronic fatigue is often a manifestation of other disorders, and is not considered a separate disease per se. Am unaware of current concepts regarding endometriosis. Should ask OB-GYN specialist. ...Read more

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Whats death rate related to systemic lupus erythematosis?

Whats death rate related to systemic lupus erythematosis?

Less now: In the 1950s, 60% of lupus patients died within five years. Now, more than 90% survive beyond five years. Many lupus patients have non-life threatening disease. Kidney or brain involvement portends a worse prognosis. ...Read more

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Is inflammatory bowel disease an inherited condition?

Is inflammatory bowel disease an inherited condition?

Sometimes: There are genetic factors to inflammatory bowel disease (ibd) and individuals with a first degree family member with ibd have a higher risk of developing ibd in their lifetime. The overall risk is still fairly low (in the 10% range). ...Read more

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Can inflammation from a severe lupus flare cause an elevated d dimer of 1600? Crp over 200. Esr 50.

Can inflammation from a severe lupus flare cause an elevated d dimer of 1600? Crp over 200. Esr 50.

See below: Elevated CRP and ESR can be signs of lupus glare up. Lupus can cause hypercoagulable state (meaning you can form clots in the body even if you don't need to). D- dimer is a test for to check for by products of clots in the body. Elevated d dimer needs to be attended by doctor asap. ...Read more

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How does cfs relate to other illnesses such as fibromyalgia, multiple chemical sensitivities, gulf war syndrome, neurally mediated hypotension, Lyme disease, and candida?

How does cfs relate to other illnesses such as fibromyalgia, multiple chemical sensitivities, gulf war syndrome, neurally mediated hypotension, Lyme disease, and candida?

Simply put...: The underlying theme describes a constellation of signs and symptoms that we have absolutely no clear, concise idea how it biologically works, how to effectively treat it, and how to address its neuro-psychiatric effects, unfortunately, it is this ambiguity that is being exploited by some quacks, to spread misinformation about each of the diagnoses mentioned (and it's not exhaustive). ...Read more

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What are the tests for systemic inflammatory response syndrome (sirs)?

SIRS: The conference concluded that the manifestations of sirs include, but are not limited to: body temperature less than 36°c(96.8°f) or greater than 38°c(100.4°f) heart rate greater than 90 beats per minute tachypnea (high respiratory rate), with than 20 breaths per minute; or, an arterial partial pressure of carbon dioxide less than 4.3 kpa (32 mmhg) white blood cell count less than 4000 cells/mm³. ...Read more

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What is the treatment for systemic inflammatory response syndrome (sirs)?

SIRS: Sirs may result from a myriad of underlying causes. Treating the cause and supportive measures are the mainstay of the treatment. ...Read more

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Is SIRS (Systemic Inflammatory Response Syndrome) commonly associated with pain?

Can be: Systemic Inflammatory Response Syndrome which is either fever or hypothermia,either high or low blood count with many WBC band forms, tachycardia and tachypnea, can be seen in infections with sepsis and in noninfectious insults such as trauma or burns. Therefore depending on the cause it can be associated with pain. ...Read more

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Can SIRS (systemic inflammatory response syndrome) be an underlying cause of delirium or be otherwise associated with delirium?

Delirium: In critically ill patients, delirium is a frequent occurrence. Investigators have found that the profile of increased inflammatory biomarkers changes in critically ill patients with delirium according to the presence or absence of clinical evidence of inflammation (either infection or systemic inflammatory response syndrome). Thus, there is a reasonable associate between the two. ...Read more

See 1 more doctor answer
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I have vomiting episodes that lead to systemic inflammatory response syndrome without sepsis. What causes sirs? Insufficient cortisol from adrenals?

Multifactorial: As a general rule, inflammatory conditions which produce the criteria necessary to term a condition sirs are induced by cytokine release, but there are many other possibilities. Generally not adrenal insufficiency. You seem to be trying to acquire a shorthand medical education. It is not that simple. ...Read more

See 2 more doctor answers
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How does systemic inflammatory response syndrome trigger problems?

Inflammation bad!: Inflammation dose many things deleterious to the body including: releases inflammatory cytokines into the blood stream. This damages your blood vessels and accelerates atherosclerosis. Clotting factors rise, which are thrombotic themselves. The body enters a catabolic state (tiisue breakdown). People feel fatigued and bad. Inflammation from any cause need to treated. ...Read more

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Respected sirs please expain about hapatitis B..how it comes..what to do and treatment?..for diabatis patient

Respected sirs please expain about hapatitis B..how it comes..what to do and treatment?..for diabatis patient

Hepatitis B: This virus is transmitted by exposure to infectious blood or body fluids. Infection at time of birth is the most often way in areas of the world where the disease is common. In areas where the disease is rare intravenous drug use and sex are the most frequent routes of infection. There is now therapy available, see a specialist. Good luck. ...Read more

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What is the difference between sepsis and sirs?

Infection: Sirs is a condition where there are systemic changes in the body which are characteristic of inflammation. Sepsis is sirs with a documented infection. ...Read more

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My roommate tested positive for sirs should I go get checked too? I m feeling healthy and everything feels normal. Thank you very much for the help.

My roommate tested positive for sirs should I go get checked too? I m feeling healthy and everything feels normal. Thank you very much for the help.

Can you clarify?: If this is a regional abbreviation for methicillin-resistant staphylococci, i'd urge you not to worry. These microbes are actually quite common and no one knows why occasionally one strain makes someone sick. Most important is that neither you nor your buddy be made to feel you're a danger to the health of others or about to get horribly sick yourself. Many think screening healthies is misguided. ...Read more

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My brother get rashes on body..why he getting rashes?please tell me sirs

My brother get rashes on body..why he getting rashes?please tell me sirs

Need more info: Too many types of rashes to help, see an MD/dermatologist to help. Bring with photos along with the who what when where of your brother's story. How long has he had it for, does it hurt, sting, itch, anything help or aggravate, any travel, any medications? ...Read more

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Dear sirs and madam, will you please, please help me. I don't know who else to turn to. I have adult adhd, and being subject to?

Dear sirs and madam, 

will you please, please help me.  I don't know who else to turn to.  
  
I have adult adhd, and being subject to?

To what exactly?: You seem very frantic (typing with all caps), and if you really need help then there's lots of help available out there. Have you discussed with your dr? If you don't have one, that's probably the best place to start. Adhd isn't usually debilitating so i wonder if there is something else which could diagnosed and treated. We cannot diagnose or treat here. For that, you need a physical examination. ...Read more

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Respected sirs what is blood infection?..how it happens and symptoms

Respected sirs what is blood infection?..how it happens and symptoms

Complicated issue: Blood infection is the lay term for sepsis. The clinical picture of sepsis is a combination of infection, tissue destruction, release of mediators by the body and co-existing diseases. You may consult this site for more info. http://www.mayoclinic.org/diseases-conditions/sepsis/basics/definition/CON-20031900 ...Read more

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Respected sirs plz explain about jaundice ..and types of jaundice.. plz sir?

Respected sirs plz explain about jaundice ..and types of jaundice.. plz sir?

Yellow: Is yellowish skin coloration due to increase in the pigment bilirubin which is from the breakdown of red blood cells. This can happen before the Liver/pre hepatic ( anemias) in the Liver/ Hepatic ( hepatitis) or after the liver/post hepatic (gallstones) For more information see your kind doctor. ...Read more

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Respected sirs what is white jaundice and it's symptoms? Plz give ur kind information sirs

Respected sirs what is white jaundice and it's symptoms? Plz give ur kind information sirs

Not a medical term: White jaundice is not a medial term. It has been used in some cultures to describe jaundice with white stools. This would be the case of complete obstructive jaundice where bilirubin secreted by the liver which turns stools brown is absent. ...Read more

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Dear sirs need advices on ecgs of patients for rapid interpretation as I am a gp and need urgent advices.Please assist by any means.

Dear sirs need advices on ecgs of patients for rapid interpretation as I am a gp and need urgent advices.Please assist by any means.

Ask cardiologist: I suggest you ask a local cardiologist or forward the ekgs to a cardiologist in another country through secure means. Without a detailed history and secure transmission, it would not be wise to diagnose here. ...Read more

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Systemic (Definition)

A condition that involves the whole body as compared to a part of the body. For example diabetes ...Read more