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Doctor insights on: Synarel

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Dr. Jeffrey Wint
3 doctors shared insights

Synarel (Overview)

Synarel is a GnRH stimulator which is a kind of women's health and pregnancy drug.


Dr. Jeffrey Wint
3 doctors shared insights

Synarel (Overview)

Synarel is a GnRH stimulator which is a kind of women's health and pregnancy drug.


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Has anyone used synarel (nafarelin) to treat endometriosis?

Has anyone used synarel (nafarelin) to treat endometriosis?

Long time: Yes, i used it to treat patients occasionally in the early-mid 1990s, as did many other specialists. It was fairly effective but cumbersome to use. I've not used it in many years, and it's overall popularity has faded significantly. ...Read more

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Has anyone used synarel (nafarelin) to treat endometriosis?

Long time: Yes, i used it to treat patients occasionally in the early-mid 1990s, as did many other specialists. It was fairly effective but cumbersome to use. I've not used it in many years, and it's overall popularity has faded significantly. ...Read more

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How does lupron (leuprolide) depot work for endometriosis?

How does lupron (leuprolide) depot work for endometriosis?

In the brain: Receptors in the brain get saturated to a that point the pulses of gnrh cannot stimulate the ovarian production of estrogen. ...Read more

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Lupron (leuprolide) shot and side effects?

Lupron (leuprolide) shot and side effects?

Hot Flashes: By far, the most common side effect is hot flashes, because Lupron (leuprolide) causes a temporary menopause. Poor sleep resulting in emotional side effects or head ache are also common. A serious effect from long-term Lupron (leuprolide) is osteoporosis. Many of these side effects are reduced or eliminated with extra "add-back" hormones. Some women have no side effects at all. ...Read more

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Is lupron 11.25 mg shot the same as Depo-Provera provera (medroxyprogesterone)?

Is lupron 11.25 mg shot the same as Depo-Provera provera (medroxyprogesterone)?

Definitely NOT: Lupron is the trade name of leuprolide, an antiandrogen medication used for a variety of ailments including prostate cancer. Depoprovera is the trade name of Medroxyprogesterone also used for a variety of things including prevention of pregnancy. Lupron comes in a depot form, Lupron depot which probably led to the question. ...Read more

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Does lupron (leuprolide) depot cause severe acne?

Does lupron (leuprolide) depot cause severe acne?

No: Lupron (leuprolide) disconnects the association of the brain with the ovaries or the brain to the testicles. This in turn suppresses fsh/lh levels. Subsequently lowering estrogen and testosterone levels. ...Read more

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What does lupron (leuprolide) do?

What does lupron (leuprolide) do?

Hormone inhibitor: Lupron (aka leuprolide) inhibits the production of testosterone and estrogen from the testes and ovaries, respectively. It is used in the treatment of a number of things including endometriosis, prostate and breast cancer and inappropriately early puberty in kiddos, each of which is made worse by excessive testosterone or estrogen secretion. ...Read more

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How long does one lupron (leuprolide) shot last?

How long does one lupron (leuprolide) shot last?

Depends: Leuprolide acetate is available in two long-acting formulations as Lupron (leuprolide) depot. It is available in a 1-month and a 3-month version. Microdose Lupron (leuprolide) as used for ivf is generally very short acting, but the pharmacology is too complex to explain here. ...Read more

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Has anyone ever taken lupron (leuprolide) shots for adenomyosis?

Has anyone ever taken lupron (leuprolide) shots for adenomyosis?

Maybe: Lupron (leuprolide) is typically used to treat endometriosis and to shrink fibroids before surgery. It would likely temporarily relieve the symptoms of adenomyosis, but would not cure it. Hysterectomy is the most common treatment option if no more pregnancies are desired. ...Read more

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Lupron (leuprolide) withdrawal symptoms for male?

Lupron (leuprolide) withdrawal symptoms for male?

Not aware of any: Generally, stopping Lupron (leuprolide) just allows the whole hypothalamic-pituitary-gonadal axis to start getting back to normal, with gradual increases in both testosterone and estrogen as the Lupron (leuprolide) wears off. In some people who have been on multiple courses of lupron, (leuprolide) or have been on it for a long time, there may not be recovery, and the low testosterone and estrogen may be permanent. ...Read more

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Gonadotropin-releasing hormone (gnrh) stimulates what?

Gonadotropin-releasing hormone (gnrh) stimulates what?

FSH,LH: Gnrh stimulates follicle stimulating hormone & luteinizing hormone which stimulates the ovary to produce estrogen and Progesterone which stimulates ovulation which causes increased Progesterone which causes secretory endometrium which prepares the endometrium to allow implantation of a fertilized egg. If no fertilized egg, Progesterone falls which stimulates gnrh to again rise & the cycle repeats. ...Read more

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Can methylprednisolone or montelukast (for asthma) effect Depo Provera (medroxyprogesterone)?

Can methylprednisolone or montelukast (for asthma)  effect Depo Provera (medroxyprogesterone)?

Usually not: the steroid affect usually does not affect the depo in correct dosages Check with your provider but you should be fine ...Read more

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Glatiramer acetate (copaxone) vs. Interferon?

Glatiramer acetate (copaxone) vs. Interferon?

See answer below: Both are used in rrms with similar efficacy levels. Copaxone (glatiramer) does not need blood monitoring and is administered as a subcutaneous sc injection daily. Side effects include injection site reactions. Interferons need lab work monitoring, can be a weekly injection into a muscle (avonex), every other day sc (betaseron) or three times a week sc (rebif). Most commo side effects include flu-like symptoms. ...Read more

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Pain from having hormone injections(gnrh agonist)?

Pain from having hormone injections(gnrh agonist)?

Unlikely: Generally no, not pain unless you mean pain at the injection site. ...Read more

Dr. Amrita Dosanjh
8 doctors shared insights

Nafarelin (Definition)

Nafarelin is a GnRH stimulator which is a kind of women's ...Read more