symptoms of polyclonal gammopathy

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I was diagnosed with RA a couple years ago. Just did IFE and PE Serum and it is suggested an apparent Polyclonal Gammopathy. What is that?

Active immune system

Rheumatoid_arthritis
The part of blood that contains antibodies is gamma globulin. Polyclonal refers to the fact that many different antibodies are present. The increase in quantity reflects a broadly activated immune system cranking out lots of antibodies. This is common in autoimmune disease and is not a concern.
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Can you explain what this might mean: "apparent polyclonal gammopathy: IgM. Kappa and Lambda increased". Immunoglobulin M is also high at 437.?

Monoclonal processes

Immunoglobulin
are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory
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What would cause constant recurring Goosebumps in left leg for no reason?. Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

Neuropathy

Neuropathy
Goosebumps are caused by stimulation of the autonomic system - which innervate the small muscles attached to each hair. Anything that causes an adrenaline rush or other activation of your sympathetic nerves (such as fear, or cold) will cause goose bumps (also known as "pilo erection"). It's also possible this is caused by a condition called autonomic hyperreflexia. Talk with your neurologist.
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Dr. Carlo Valencia answered:

Been diagnosed with peripheral neuropathy Blood test showed high immunoglobulin M w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

PlasmaCellDIsorder

Blood
May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces Immunoglobulin(antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see Hematologist (blood doctor specialist).
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Dr. Sewa Legha answered:

Slightly elevated Beta Fraction from Serum Protein Electrophoresis. beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.

This report is of no

Electrophoresis
These values are of no particular concern. This test is mainly useful to check for Monoclonal peaks...which you do not have.
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Dr. Liawaty Ho answered:

How does having Polyclonal Gammopathy correlate with Lupus- I have Lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an SPEP be4 lupus and I had that?

Polyclonal gamma pat

Erysipelas
Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy . the presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe . Discuss with your rheumatologist further.
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Dr. Ed Friedlander answered:

What is gammopathy?

Immoglobulin finding

Kahler_disease
If a person has an unusually large number of antibodies, but not a single one in great excess, we speak of a polyclonal gammopathy; it's never a specific finding. An abundance of a single antibody is a monoclonal antibody "spike" that is quite common but may indicate or precede (often by decades) plasma cell "multiple" myeloma.
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Dr. Ahmad M Hadied answered:

What are the tests for gammopathy?

Blood urine and bone

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Blood tests. A serum protein electrophoresis. Urine tests. Urine tests may be performed to determine if the abnormal protein is being released in the urine or to diagnose any kidney damage as a result of the protein. Bone marrow tests. A bone marrow biopsy may be completed to determine the severity of the problem.
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Dr. Ahmad M Hadied answered:

What is monoclonal gammopathy about?

Please read below

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According to Mayo Clinic.Monoclonal gammopathy of undetermined significance (MGUS) is a common precancerous condition affecting people 50 years of age and older. It was first described by Mayo Clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein. Has(1 percent each year) of progressing to a blood cancer Muliple myloma.
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Dr. Ahmad M Hadied answered:

What is the treatment for gammopathy?

Monoclonal gammopath

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According to Mayo Clinic were the diease was discovered.No treatment is required for people diagnosed with monoclonal gammopathy of undetermined significance (MGUS). About 20 percent of people with MGUS develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Therefore, careful observation and follow-up are important.
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